Carcinoma of the Vagina

  • Robert C. Knapp
Chapter
Part of the Developments in Oncology book series (DION, volume 16)

Abstract

Carcinoma of the vagina is defined as a malignant lesion in the vagina which does not involve the external os of the cervix superiorly, nor the vulva interiorly. It accounts for about 2% of all gynecologic malignancies (1, 2). Herbst et al., in 1977 reported on the occurrence of clear cell adenocarcinoma of the vagina in women in their late teens and early twenties. This particular carcinoma was found to be related to the use of diethylstilbestrol (DES) by their mothers during pregnancy (3). In order to better delineate clear cell carcinoma, it will be described in a separate section in this chapter.

Keywords

Cervical Intraepithelial Neoplasia Clear Cell Carcinoma Radical Hysterectomy Pelvic Lymph Node Dissection Pelvic Exenteration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Rutledge, F. 1967. Cancer of the vagina. Am. J. Obstet. Gynecol. 97:635.PubMedGoogle Scholar
  2. 2.
    Herbst, A.L., Green, T.H. Jr., Ulfelder, H. 1970. Primary carcinoma of the vagina. Am. J. Obstet. Gynecol. 106:210.PubMedGoogle Scholar
  3. 3.
    Herbst, A.L. and Scully, R.E. 1970. Adenocarcinoma of the vagina in adolescence: A report of 7 cases including 6 clear cell adenocarcinomas (so-called mesonephromas). Cancer 27:745.CrossRefGoogle Scholar
  4. 4.
    Pride, G.L., Schultz, A.E., Chuprevich, T.W. et al. 1979. Primary invasive squamous carcinoma of the vagina. Obstet. Gynecol. 53:218.PubMedGoogle Scholar
  5. 5.
    Perez, C.A. and Camel, H.M. 1982. Long-term follow-up in radiation therapy of carcinoma of the vagina. Cancer 49: 1309.CrossRefGoogle Scholar
  6. 6.
    Plentl, A.A., Friedman, E.A. 1971. Lymphatic System of the Female Genitalia: The Morphologic Basis of Oncologic Diagnosis and Therapy, pp 51–74, Philadelphia, W.B. Saunders.Google Scholar
  7. 7.
    Tavassoli, F.A., Norris, H.J. 1979. Smooth muscle tumors of the vulva. Obstet. Gynecol. 53:213.PubMedGoogle Scholar
  8. 8.
    Chung, A.F., Woodruff, J.M., Lewis, J.L. 1975. Malignant melanoma of the vulva. Obstet. Gynecol. 45:638.PubMedCrossRefGoogle Scholar
  9. 9.
    Lee, R.A., Symmonds, R.E. 1976. Recurrent carcinoma in situ of the vagina in patients previously treated for in situ carcinoma of the cervix. Obstet. Gynecol. 48:61.PubMedGoogle Scholar
  10. 10.
    Herbst, A.L. and Bern, H.A. 1981. Developmental effect of Diethylstilbestrol (DES) in Pregnancy. New York, N.Y., Thieme Stratton, Inc.Google Scholar
  11. 11.
    O’Brien, P.C., Noller, K.L., Robboy, S.J., et al. 1979. Vaginal epithelial changes in young women enrolled in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. Obstet. Gynecol. 53:300.PubMedGoogle Scholar
  12. 12.
    Robboy, S.J., Scully, R.E., Herbst, A.L. 1975. Pathology of the vaginal and cervical abnormalities associated with prenatal exposure to Diethylstilbestrol. J. Reprod. Med. 15–13.Google Scholar
  13. 13.
    Burke, J., Antonioli, D., Rosen, S. 1978. Vaginal and cervical squamous cell dysplasia in women exposed to Diethylstilbestrol in utero. Am. J. Obstet. Gynecol. 132:537.PubMedGoogle Scholar
  14. 14.
    Robboy, S.J., Keh, P.C., Nickerson, R.J., et al. 1978. Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal exposure to diethylstilbestrol. Obstet. Gynecol. 51:528.PubMedCrossRefGoogle Scholar
  15. 15.
    Fowler, W.C., Schmidt, G., Edelman, D.A., et al. 1981. Risks of cervical intraepithelial neoplasia among DES- exposed women. Obstet. Gynecol. 58:720.PubMedGoogle Scholar
  16. 16.
    Robboy, S.J., Herbst, A.L., Scully, R.E. 1974. Clear cell adenocarcinoma of the vagina and cervix in young females: Analyses of 37 tumors that persisted or recurred after primary therapy. Cancer 34–606.Google Scholar
  17. 17.
    Pietros, R.J., Szego, C.M., Mangon, C.E., et al. 1978. Elevated serum Cathepsin B-1 and vaginal pathology after prenatal DES exposure. Obstet. Gynecol. 52:321.Google Scholar

Copyright information

© Martinus Nijhoff Publishers, The Hague 1984

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  • Robert C. Knapp

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