Advertisement

Perinatal pharmacology in ruminant models

  • Y. Ruckebusch

Abstract

The primary physiological concern of the newborn is simply to survive35. This is achieved only by the onset of a vast air–blood interface for gas exchange, the separation of pulmonary and systemic circulations, the maintenance of body heat which supplies the energetic cost for moving, and the development of immune responsiveness.

Keywords

Amniotic Fluid Fetal Growth Ductus Venosus Fetal Lamb Uterine Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Alexander, G. (1964). Studies on the placenta of the sheep (Ovis aries L.). Placental size. J. Reprod. Fertil., 7, 289–305; Effect of reduction in the number of caruncles. Ibid., 307–22Google Scholar
  2. 2.
    Bareham, J. R. (1976). The behaviour of lambs on the first day after birth. Br. Vet. J, 132, 152–62PubMedGoogle Scholar
  3. 3.
    Barlow, S. M. (1982). Drugs in pregnancy. Trends Pharm. Sci, 3, 254–6CrossRefGoogle Scholar
  4. 4.
    Battaglia, F. C. and Meschia, G. (1981). Foetal and placental metabolisms: their interrelationship and impact upon maternal metabolism. Proc. Nutr. Soc, 40, 99–113CrossRefPubMedGoogle Scholar
  5. 5.
    Brinsmead, M. W., Waters, M. J. and Thorburn, G. D. (1980). Increase in placental lactogen and somatomedins after fetal nephrectomy. J. Dev. Physiol, 2, 205–18PubMedGoogle Scholar
  6. 6.
    Bueno, L. and Ruckebusch, Y. (1979). Perinatal development of intestinal myoelectrical activity in dogs and sheep. Am. J. Physiol, 237, E61–7PubMedGoogle Scholar
  7. 7.
    Bureau, M. A. and Begin, R. (1982). Postnatal maturation of the respiratory response to O2 in awake newborn lambs. J. Appl. Physiol, 52, 428–33PubMedGoogle Scholar
  8. 8.
    Chernick, V. and Craig, R. J. (1982). Naloxone reverses neonatal depression caused by fetal asphyxia. Science, 216, 1252–4CrossRefPubMedGoogle Scholar
  9. 9.
    Creasy, R. K., Barrett, C. T., De Swift, M. et al (1972). Experimental intrauterine growth retardations in the sheep. Am. J. Obstet. Gynecol, 112, 566–73PubMedGoogle Scholar
  10. 10.
    Dancis, J. and Hwang, J. C. (1974). Perinatal Pharmacology: Problems and Priorities. p. 128. ( New York: Raven Press )Google Scholar
  11. 11.
    Dardillat, C. (1982). Comment obtenir des veaux résistants. Bull. Techn. C.R.Z. V. Theix, I.N.R.A, 47, 37–45Google Scholar
  12. 12.
    Davicco, M. J., Lefaivre, J. and Bartlet, J. P. (1982). Plasma iodothyronine levels in lambs during the perinatal period: influence of thyrotropin injection. Reprod. Nutr. Dev, 22, 557–68CrossRefPubMedGoogle Scholar
  13. 13.
    Dawes, G. S. and Bost, J. (1977). Homéostasie périnatale du milieu intérieur. Symposium on The Maintenance of the Internal Environment in the Foetus and Newborn in Domestic Animals, Lyon. Ann. Rech. Vét., 8, 343–501Google Scholar
  14. 14.
    De Prins, F. A. and Van Assche, A. (1982). Intra–uterine growth retardation and development of endocrine pancreas in the experimental rat. Biol. Neonate, 41, 16–21CrossRefPubMedGoogle Scholar
  15. 15.
    Dufty, J. H. and Sloss, V. (1977). Anoxia in the bovine foetus. Aust. Vet. J, 53, 262–7CrossRefPubMedGoogle Scholar
  16. 16.
    Edelstone, D. I. (1980). Regulation of blood flow through the ductus venosus. J. Dev. Physiol, 2, 219–38PubMedGoogle Scholar
  17. 17.
    Fisher, E. W. (1980). Neonatal survival. Br. Vet. J, 136, 585–89PubMedGoogle Scholar
  18. 18.
    Hetzel, B. S. and Smith, R. M. (1981). Fetal Brain Disorders. ( Amsterdam: Elsevier Biomedical Press )Google Scholar
  19. 19.
    Hopkins, P. S. and Thorburn, G. D. (1972). The effects of fetal thyroidectomy on the development of the ovine fetus. J. Endocrinol, 54, 55–66CrossRefPubMedGoogle Scholar
  20. 20.
    Ioffe, S., Jansen, A. H., Russell, B. J. et al (1980). Sleep, wakefulness and the monosynaptic reflex in fetal and newborn lambs. Pflügers Arch, 388, 149–57CrossRefPubMedGoogle Scholar
  21. 21.
    Lascelles, A. K. and Setchell, B. P. (1959). Hypothyroidism in sheep. Aust. J. Biol, 12, 445–65Google Scholar
  22. 22.
    Lewis, A. B., Evans, W. N. and Sischo, W. (1982). Plasma catecholamine responses to hypoxemia in fetal lambs. Biol. Neonate, 41, 115–22CrossRefPubMedGoogle Scholar
  23. 23.
    Lubis, I., Ladds, P. W. and Reilly, L. R. (1982). Age associated morphological changes in the lymphoid system of tropical cattle. Res. Vet. Sci, 32, 270–7PubMedGoogle Scholar
  24. 24.
    Marshall, A. W., Mihaly, G. W., Smallwood, R. A. et al (1981). Foetal hepatic function: the disposition of propranolol in the pregnant sheep. Res. Commun. Chem. Pathol. Pharmacol, 32, 3–26PubMedGoogle Scholar
  25. 25.
    Mcintosh, G. H. (1978). Foetal thyroidectomy and hydranencephaly in lambs. Aust. Vet. J, 54, 408–9CrossRefPubMedGoogle Scholar
  26. 26.
    Mellor, D. J. and Murray, L. (1982). Effects on the rate of increase in fetal girth of refeeding ewes after short periods of severe nutrition during late pregnancy. Res. Vet. Sci, 32, 377–82PubMedGoogle Scholar
  27. 27.
    Mirkin, B. L. (1976). Perinatal Pharmacology and Therapeutics. ( New York: Academic Press).Google Scholar
  28. 28.
    Molla, A. (1978). Immunoglobulin levels in calves fed colostrum by stomach tube. Vet. Rec, 103, 377–80CrossRefPubMedGoogle Scholar
  29. 29.
    Morishima, H. O., Sakuma, K., Bruce, S. L. et al (1980). The effect of diazepam on maternal and fetal stress responses in the sheep. Dev. Pharmacol. Ther, 1, 364–71Google Scholar
  30. 30.
    Moss, I. R. and Scarpelli, E. M. (1979). Generation and regulation of breathing in utero: fetal C02 response test. J. Appl. Physiol, 47, 527–31PubMedGoogle Scholar
  31. 31.
    Nathanielsz, P. W., Silver, M. and Comline, R. S. (1973). Plasma triiodothyronine concentration in the foetal and newborn lamb. J. Endocrinol, 58, 683–4CrossRefPubMedGoogle Scholar
  32. 32.
    Noble, N. A., Cabalum, T. C., Nathanielsz, P. W. et al (1982). Erythrocyte enzymes in sheep: comparison of activity in fetal, newborn, maternal and nonpregnant ewe erythrocytes. Biol. Neonate, 41, 161–71CrossRefPubMedGoogle Scholar
  33. 33.
    Pipkin, B. and Kirkpatrick, S. M. L. (1973). The blood volumes of fetal and newborn sheep. Q. J. Exp. Physiol, 58, 181–8Google Scholar
  34. 34.
    Quilligan, E. J., Clewlow, F., Johnston, B. M. etal. (1981). Effect of 5—hydroxytryptophan on electrocortical activity and breathing movements of fetal sheep. Am. J. Obstet. Gynecol., 141, 271–5PubMedGoogle Scholar
  35. 35.
    Randall, G. C. B. (1978). Perinatal mortality: some problems of adaptation at birth. Adv. Vet. Sci. Comp. Med, 22, 53–81PubMedGoogle Scholar
  36. 36.
    Reuss, L., Parer, J. T., Harris, J. L. et al (1982). Hemodynamic effects of adrenergic blockade during hypoxia in fetal sheep. Am. J. Obstet. Gynecol, 142, 410–15PubMedGoogle Scholar
  37. 37.
    Robinson, J. S., Hart, I. P., Kingston, E. J. et al (1980). Studies on the growth of the foetal sheep. The effect of reduction of placental size on hormone concentration in foetal lambs. J. Dev. Physiol, 2, 239–48PubMedGoogle Scholar
  38. 38.
    Roth, J. A. and Kaeberle, M. L. (1982). Effect of glucocorticoids on the bovine immune system. J. Am. Vet. Med. Assoc, 180, 894–901PubMedGoogle Scholar
  39. 39.
    Ruckebusch, Y. (1972). Development of sleep and wakefulness in the foetal lamb. Electro– enceph. Clin. Neurophysiol, 32, 119–25CrossRefGoogle Scholar
  40. 40.
    Ruckebusch, Y. and Grivel, M. L. (1974). A technique for long–term studies of the electrical activity of the gut in the foetus and neonate. In Daniel, E. et al. (eds.) Proceedings of the 4th International Symposium on Gastrointestinal Motility, Banff, pp. 428–34. ( Vancouver: Mitchell Press )Google Scholar
  41. 41.
    Ruckebusch, Y., Gaujoux, M. and Eghbali, B. (1976). Placental transfer of CNS depressants in sheep. Eur. J. Pharmacol, 37, 193–6CrossRefPubMedGoogle Scholar
  42. 42.
    Rudolph, A. M. and Heymann, M. A. (1979). Developmental considerations in cardiac failure. Les Colloques de I’INSERM, 89, 235–44Google Scholar
  43. 43.
    Scott, G. H., Marx, D. B., Menefee, B. E. etal. (1979). Colostral immunoglobulin transfer in calves. I. Period of absorption. J. Dairy Sci., 62, 1632–8CrossRefGoogle Scholar
  44. 44.
    Starling, M. B., Neutze, J. M. and Elliott, R. B. (1978). Effect of prostaglandins and some methyl derivatives on the ductus arteriosus. In Coceani, F. and Olley, P. M. (eds.) Prostaglandins and Perinatal Medicine. Advances in Prostaglandin and Thromboxane Research. Vol. IV, pp. 335–43. ( New York: Raven Press )Google Scholar
  45. 45.
    Szeto, H. H. (1982). Pharmacokinetics in the ovine maternal–fetal unit. Ann. Rev. Pharmacol. Toxicol, 22, 221–43CrossRefGoogle Scholar
  46. 46.
    Tabsch, K., Nuwayhid, B., Murad, S. et al (1982). Circulatory effects of chemical sympathectomy in fetal, neonatal and adult sheep. Am. J. Physiol, 243, 113–32Google Scholar
  47. 47.
    Thorburn, G. D. (1974). The role of the thyroid gland and kidneys in fetal growth. In Size at Birth, Ciba Foundation Symposium 27. pp. 185–200. ( North Holland: Elsevier Excerpta Medica )Google Scholar
  48. 48.
    Vauthier, G. (1964). Etude expérimentale du passage de quelques substances à effet pharmacodynamique de la mère au foetus. Thèse Doct. Vét., ParisGoogle Scholar
  49. 49.
    Welsch, F. (1972). Placental transfer and fetal uptake of drugs. J. Vet. Pharmacol. Ther, 5, 91–104CrossRefGoogle Scholar
  50. 50.
    Wigglesworth, J. S. (1964). Experimental growth retardation in the foetal rat. J. Pathol. Bact., 88, 1–13CrossRefGoogle Scholar
  51. 51.
    Wintour, E. M., Coghlan, J. P., Hardy, K. J. etal (1980). Placental transfer of aldosterone in the sheep. J. Endocrinol., 86, 305–10CrossRefPubMedGoogle Scholar
  52. 52.
    Zink, J. and Van Petten, G. R. (1980). The effect of norepinephrine on blood flow through the fetal liver and ductus venosus. Am. J. Obstet. Gynecol., 137., 71–7PubMedGoogle Scholar
  53. 53.
    Zachman, R. D. and Farrell, P. M. (1982). Use of prenatal corticosteroids. In Farrell, P. M. (ed.) Lung Development. Vol. II, pp. 297–302. ( New York: Academic Press )Google Scholar

Copyright information

© MTP Press Limited 1983

Authors and Affiliations

  • Y. Ruckebusch

There are no affiliations available

Personalised recommendations