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Perinatal pharmacology in ruminant models

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Veterinary Pharmacology and Toxicology

Abstract

The primary physiological concern of the newborn is simply to survive35. This is achieved only by the onset of a vast air–blood interface for gas exchange, the separation of pulmonary and systemic circulations, the maintenance of body heat which supplies the energetic cost for moving, and the development of immune responsiveness.

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References

  1. Alexander, G. (1964). Studies on the placenta of the sheep (Ovis aries L.). Placental size. J. Reprod. Fertil., 7, 289–305; Effect of reduction in the number of caruncles. Ibid., 307–22

    Google Scholar 

  2. Bareham, J. R. (1976). The behaviour of lambs on the first day after birth. Br. Vet. J, 132, 152–62

    CAS  PubMed  Google Scholar 

  3. Barlow, S. M. (1982). Drugs in pregnancy. Trends Pharm. Sci, 3, 254–6

    Article  Google Scholar 

  4. Battaglia, F. C. and Meschia, G. (1981). Foetal and placental metabolisms: their interrelationship and impact upon maternal metabolism. Proc. Nutr. Soc, 40, 99–113

    Article  CAS  PubMed  Google Scholar 

  5. Brinsmead, M. W., Waters, M. J. and Thorburn, G. D. (1980). Increase in placental lactogen and somatomedins after fetal nephrectomy. J. Dev. Physiol, 2, 205–18

    CAS  PubMed  Google Scholar 

  6. Bueno, L. and Ruckebusch, Y. (1979). Perinatal development of intestinal myoelectrical activity in dogs and sheep. Am. J. Physiol, 237, E61–7

    CAS  PubMed  Google Scholar 

  7. Bureau, M. A. and Begin, R. (1982). Postnatal maturation of the respiratory response to O2 in awake newborn lambs. J. Appl. Physiol, 52, 428–33

    CAS  PubMed  Google Scholar 

  8. Chernick, V. and Craig, R. J. (1982). Naloxone reverses neonatal depression caused by fetal asphyxia. Science, 216, 1252–4

    Article  CAS  PubMed  Google Scholar 

  9. Creasy, R. K., Barrett, C. T., De Swift, M. et al (1972). Experimental intrauterine growth retardations in the sheep. Am. J. Obstet. Gynecol, 112, 566–73

    CAS  PubMed  Google Scholar 

  10. Dancis, J. and Hwang, J. C. (1974). Perinatal Pharmacology: Problems and Priorities. p. 128. ( New York: Raven Press )

    Google Scholar 

  11. Dardillat, C. (1982). Comment obtenir des veaux résistants. Bull. Techn. C.R.Z. V. Theix, I.N.R.A, 47, 37–45

    Google Scholar 

  12. Davicco, M. J., Lefaivre, J. and Bartlet, J. P. (1982). Plasma iodothyronine levels in lambs during the perinatal period: influence of thyrotropin injection. Reprod. Nutr. Dev, 22, 557–68

    Article  CAS  PubMed  Google Scholar 

  13. Dawes, G. S. and Bost, J. (1977). Homéostasie périnatale du milieu intérieur. Symposium on The Maintenance of the Internal Environment in the Foetus and Newborn in Domestic Animals, Lyon. Ann. Rech. Vét., 8, 343–501

    Google Scholar 

  14. De Prins, F. A. and Van Assche, A. (1982). Intra–uterine growth retardation and development of endocrine pancreas in the experimental rat. Biol. Neonate, 41, 16–21

    Article  PubMed  Google Scholar 

  15. Dufty, J. H. and Sloss, V. (1977). Anoxia in the bovine foetus. Aust. Vet. J, 53, 262–7

    Article  CAS  PubMed  Google Scholar 

  16. Edelstone, D. I. (1980). Regulation of blood flow through the ductus venosus. J. Dev. Physiol, 2, 219–38

    CAS  PubMed  Google Scholar 

  17. Fisher, E. W. (1980). Neonatal survival. Br. Vet. J, 136, 585–89

    CAS  PubMed  Google Scholar 

  18. Hetzel, B. S. and Smith, R. M. (1981). Fetal Brain Disorders. ( Amsterdam: Elsevier Biomedical Press )

    Google Scholar 

  19. Hopkins, P. S. and Thorburn, G. D. (1972). The effects of fetal thyroidectomy on the development of the ovine fetus. J. Endocrinol, 54, 55–66

    Article  CAS  PubMed  Google Scholar 

  20. Ioffe, S., Jansen, A. H., Russell, B. J. et al (1980). Sleep, wakefulness and the monosynaptic reflex in fetal and newborn lambs. Pflügers Arch, 388, 149–57

    Article  CAS  PubMed  Google Scholar 

  21. Lascelles, A. K. and Setchell, B. P. (1959). Hypothyroidism in sheep. Aust. J. Biol, 12, 445–65

    Google Scholar 

  22. Lewis, A. B., Evans, W. N. and Sischo, W. (1982). Plasma catecholamine responses to hypoxemia in fetal lambs. Biol. Neonate, 41, 115–22

    Article  CAS  PubMed  Google Scholar 

  23. Lubis, I., Ladds, P. W. and Reilly, L. R. (1982). Age associated morphological changes in the lymphoid system of tropical cattle. Res. Vet. Sci, 32, 270–7

    CAS  PubMed  Google Scholar 

  24. Marshall, A. W., Mihaly, G. W., Smallwood, R. A. et al (1981). Foetal hepatic function: the disposition of propranolol in the pregnant sheep. Res. Commun. Chem. Pathol. Pharmacol, 32, 3–26

    CAS  PubMed  Google Scholar 

  25. Mcintosh, G. H. (1978). Foetal thyroidectomy and hydranencephaly in lambs. Aust. Vet. J, 54, 408–9

    Article  CAS  PubMed  Google Scholar 

  26. Mellor, D. J. and Murray, L. (1982). Effects on the rate of increase in fetal girth of refeeding ewes after short periods of severe nutrition during late pregnancy. Res. Vet. Sci, 32, 377–82

    CAS  PubMed  Google Scholar 

  27. Mirkin, B. L. (1976). Perinatal Pharmacology and Therapeutics. ( New York: Academic Press).

    Google Scholar 

  28. Molla, A. (1978). Immunoglobulin levels in calves fed colostrum by stomach tube. Vet. Rec, 103, 377–80

    Article  CAS  PubMed  Google Scholar 

  29. Morishima, H. O., Sakuma, K., Bruce, S. L. et al (1980). The effect of diazepam on maternal and fetal stress responses in the sheep. Dev. Pharmacol. Ther, 1, 364–71

    CAS  Google Scholar 

  30. Moss, I. R. and Scarpelli, E. M. (1979). Generation and regulation of breathing in utero: fetal C02 response test. J. Appl. Physiol, 47, 527–31

    CAS  PubMed  Google Scholar 

  31. Nathanielsz, P. W., Silver, M. and Comline, R. S. (1973). Plasma triiodothyronine concentration in the foetal and newborn lamb. J. Endocrinol, 58, 683–4

    Article  CAS  PubMed  Google Scholar 

  32. Noble, N. A., Cabalum, T. C., Nathanielsz, P. W. et al (1982). Erythrocyte enzymes in sheep: comparison of activity in fetal, newborn, maternal and nonpregnant ewe erythrocytes. Biol. Neonate, 41, 161–71

    Article  CAS  PubMed  Google Scholar 

  33. Pipkin, B. and Kirkpatrick, S. M. L. (1973). The blood volumes of fetal and newborn sheep. Q. J. Exp. Physiol, 58, 181–8

    Google Scholar 

  34. Quilligan, E. J., Clewlow, F., Johnston, B. M. etal. (1981). Effect of 5—hydroxytryptophan on electrocortical activity and breathing movements of fetal sheep. Am. J. Obstet. Gynecol., 141, 271–5

    CAS  PubMed  Google Scholar 

  35. Randall, G. C. B. (1978). Perinatal mortality: some problems of adaptation at birth. Adv. Vet. Sci. Comp. Med, 22, 53–81

    CAS  PubMed  Google Scholar 

  36. Reuss, L., Parer, J. T., Harris, J. L. et al (1982). Hemodynamic effects of adrenergic blockade during hypoxia in fetal sheep. Am. J. Obstet. Gynecol, 142, 410–15

    CAS  PubMed  Google Scholar 

  37. Robinson, J. S., Hart, I. P., Kingston, E. J. et al (1980). Studies on the growth of the foetal sheep. The effect of reduction of placental size on hormone concentration in foetal lambs. J. Dev. Physiol, 2, 239–48

    CAS  PubMed  Google Scholar 

  38. Roth, J. A. and Kaeberle, M. L. (1982). Effect of glucocorticoids on the bovine immune system. J. Am. Vet. Med. Assoc, 180, 894–901

    CAS  PubMed  Google Scholar 

  39. Ruckebusch, Y. (1972). Development of sleep and wakefulness in the foetal lamb. Electro– enceph. Clin. Neurophysiol, 32, 119–25

    Article  CAS  Google Scholar 

  40. Ruckebusch, Y. and Grivel, M. L. (1974). A technique for long–term studies of the electrical activity of the gut in the foetus and neonate. In Daniel, E. et al. (eds.) Proceedings of the 4th International Symposium on Gastrointestinal Motility, Banff, pp. 428–34. ( Vancouver: Mitchell Press )

    Google Scholar 

  41. Ruckebusch, Y., Gaujoux, M. and Eghbali, B. (1976). Placental transfer of CNS depressants in sheep. Eur. J. Pharmacol, 37, 193–6

    Article  CAS  PubMed  Google Scholar 

  42. Rudolph, A. M. and Heymann, M. A. (1979). Developmental considerations in cardiac failure. Les Colloques de I’INSERM, 89, 235–44

    Google Scholar 

  43. Scott, G. H., Marx, D. B., Menefee, B. E. etal. (1979). Colostral immunoglobulin transfer in calves. I. Period of absorption. J. Dairy Sci., 62, 1632–8

    Article  Google Scholar 

  44. Starling, M. B., Neutze, J. M. and Elliott, R. B. (1978). Effect of prostaglandins and some methyl derivatives on the ductus arteriosus. In Coceani, F. and Olley, P. M. (eds.) Prostaglandins and Perinatal Medicine. Advances in Prostaglandin and Thromboxane Research. Vol. IV, pp. 335–43. ( New York: Raven Press )

    Google Scholar 

  45. Szeto, H. H. (1982). Pharmacokinetics in the ovine maternal–fetal unit. Ann. Rev. Pharmacol. Toxicol, 22, 221–43

    Article  CAS  Google Scholar 

  46. Tabsch, K., Nuwayhid, B., Murad, S. et al (1982). Circulatory effects of chemical sympathectomy in fetal, neonatal and adult sheep. Am. J. Physiol, 243, 113–32

    Google Scholar 

  47. Thorburn, G. D. (1974). The role of the thyroid gland and kidneys in fetal growth. In Size at Birth, Ciba Foundation Symposium 27. pp. 185–200. ( North Holland: Elsevier Excerpta Medica )

    Google Scholar 

  48. Vauthier, G. (1964). Etude expérimentale du passage de quelques substances à effet pharmacodynamique de la mère au foetus. Thèse Doct. Vét., Paris

    Google Scholar 

  49. Welsch, F. (1972). Placental transfer and fetal uptake of drugs. J. Vet. Pharmacol. Ther, 5, 91–104

    Article  Google Scholar 

  50. Wigglesworth, J. S. (1964). Experimental growth retardation in the foetal rat. J. Pathol. Bact., 88, 1–13

    Article  CAS  Google Scholar 

  51. Wintour, E. M., Coghlan, J. P., Hardy, K. J. etal (1980). Placental transfer of aldosterone in the sheep. J. Endocrinol., 86, 305–10

    Article  CAS  PubMed  Google Scholar 

  52. Zink, J. and Van Petten, G. R. (1980). The effect of norepinephrine on blood flow through the fetal liver and ductus venosus. Am. J. Obstet. Gynecol., 137., 71–7

    CAS  PubMed  Google Scholar 

  53. Zachman, R. D. and Farrell, P. M. (1982). Use of prenatal corticosteroids. In Farrell, P. M. (ed.) Lung Development. Vol. II, pp. 297–302. ( New York: Academic Press )

    Google Scholar 

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Authors
  1. Y. Ruckebusch
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Editor information

Editors and Affiliations

  1. Ecole Nationale Vétérinaire, 23, chemin des Capelles, 31076, Toulouse Cédex, France

    Yves Ruckebusch

  2. Pharmacologie-Toxicologie, INRA, 180, chemin de Tournefeuille, 31300, Toulouse, France

    Pierre-Louis Toutain

  3. College of Veterinary Medicine, University of Illinois, 61801, Urbana, Illinois, USA

    Gary D. Koritz

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© 1983 MTP Press Limited

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Ruckebusch, Y. (1983). Perinatal pharmacology in ruminant models. In: Ruckebusch, Y., Toutain, PL., Koritz, G.D. (eds) Veterinary Pharmacology and Toxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6604-8_1

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  • DOI: https://doi.org/10.1007/978-94-009-6604-8_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6606-2

  • Online ISBN: 978-94-009-6604-8

  • eBook Packages: Springer Book Archive

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