In Vitro Chemotherapy as a Prelude to Autologous Marrow Transplantation in Hematologic Malignancy

  • George W. Santos
  • Herbert Kaizer
Chapter
Part of the Developments in Oncology book series (DION, volume 19)

Abstract

The successful application of autologous marrow transplantation to the treatment of neoplastic disease has three requirements: 1) It must be possible to obtain and viably store sufficient numbers of hematopoietic stem cells to insure recovery of hematologic and immunologic function; 2) Clonogenic tumor cells must be absent from the hematopoietic stem cell inoculum, and 3) The tumor remaining in the patient must be sensitive to an intensive pulse of pre-transplant therapy at doses that have acceptable extramedullary toxicity.

Keywords

Marrow Transplantation Acute Leukemia Total Body Irradiation Autologous Transplant Autologous Bone Marrow Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media Dordrecht 1984

Authors and Affiliations

  • George W. Santos
  • Herbert Kaizer

There are no affiliations available

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