Role of macrophage-complement receptors and macrophage complement uptake of zymosan

  • R. A. B. Ezekowitz
  • R. B. Sim
  • S. Gordon
Chapter

Abstract

Circulating monocytes and tissue macrophages secrete complement proteins and have distinct receptors for some of these secreted products. Although hepatocytes and possibly epithelial cells are major sources of plasma complement (1), macrophages synthesize C1 subcomponents, (2, 3); C4 (4, 5); C2 (5, 6, 7); C5 (8), C3 (2, 8) and all components of the alternative pathway and its control proteins (8). Current evidence indicates that macrophages bear at least two distinct receptors for fragments of activated C3 (10, 11). The type one complement receptor, CR1 (205 Kd) displays specificity for activated C3 (C3b) (12) and C4 (C4b) (13). CR1 interacts with iC3b, the product of C3b cleavage by factor H and I (10), although anti-CR1 antibodies that block C3b-dependent rosetting do not block iC3b-dependent rosetting (14, 15). The type three complement receptor, CR3 (170 and 95 Kd) interacts with iC3b (16, 17) and possibly with the further degradation product C3dg (10).

Keywords

Human Monocyte Complement Receptor Human Peripheral Blood Monocyte Zymosan Particle Macro Phage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1985

Authors and Affiliations

  • R. A. B. Ezekowitz
  • R. B. Sim
  • S. Gordon

There are no affiliations available

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