Progress in Radiopharmacy pp 579-589 | Cite as
Inhaled Aerosols: Deposition and Clearance
Abstract
Aerosols are widely used in the lung for therapeutic, diagnostic and experimental purposes. Filtration of inhaled particles out of the airstream occurs due to the aerodynamic defences of the airways above the larynx which ensure that a small proportion only reaches the bronchial tree. In the lower airways (those below the larynx) the air flow conditions which are determined to a large extent, by the branching architecture of the tracheobronchial tree ensure that many particles will deposit centrally (i.e. in the proximal airways). However, changes of the mode of inhalation and physical properties of the aerosol can result in differing deposition patterns of these particles within the lungs. The site of deposition of inhaled particles within the lungs will determine the mechanism(s) involved for their subsequent clearance. In this article clearance due to particle solubility will not be considered since it will be covered elsewhere in this symposium.
Keywords
Settling Velocity Peak Expiratory Flow Rate Mucociliary Clearance Tracheobronchial Tree Aerosol DepositionPreview
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