Developments in Cyclodextrin Applications in Drug Formulations

  • Tsuneji Nagai
Conference paper
Part of the Advances in Inclusion Science book series (AIS, volume 4)

Abstract

With regard to recent developments in cyclodextrin (CD) applications in drug formulations, here will be described on the basis mainly of (a) novel preparative methods of CD inclusion complexes, (b) effects of CDs on bioavailability and disposion of drugs and (c) absorption enhancement by CD derivatives in transdermal application. (a) When inclusion complex of cinnarizine (CN) with β-CD was prepared by a spray-drying method, it was very stable under heating and highly humid conditions. (b-1) CDs gave influence on hypnotic potency and disposition of barbiturates in intravenous and intraperitoneal administrations. (b-2) The bioavailability of CN on oral administration of the complex, which was comparable with that of CN alone, was enhanced by simultaneous administration of competing agents, such as DL-phenylalanine. (c) When tolnaftate (TOL), antifungal drug, was administered percutaneously in the form of the complex with dimethyl-β-CD and water-soluble β-CD polymer, it was absorbed in the skin, and the concentration was kept high compared with the case of TOL alone.

Keywords

Inclusion Complex Stability Constant Physical Mixture Drug Formulation Percutaneous Absorption 
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Copyright information

© D. Reidel Publishing Company 1987

Authors and Affiliations

  • Tsuneji Nagai
    • 1
  1. 1.Department of PharmaceuticsHoshi University EbaraShinagawa-ku, TokyoJapan

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