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The Challenge of Chronic Virus Infections

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Part of the New Perspectives in Clinical Microbiology book series (NPCM, volume 13)

Abstract

The career and contributions of Prof. Piet De Somer have bridged the era between the solution of major problems concerning acute virus infections and the newly emerging problems concerning the control of chronic infections due to microorganisms and especially those caused by viruses. His work on the ribonucleic acid of poliovirus hallmarked the beginning of molecular virology, and helped related investigations to stay the fear of poliomyelitis epidemics. He then pursued investigations on antiviral drugs and interferon, work still of great interest and importance. His strong interest in cancer viruses at a time when it was widely believed that viruses played no role in human neoplastic disease, has been amply justified by the discovery of a class of retroviruses associated with human T-cell lymphomas (HTLV) and acquired immunodeficiency syndrome (AIDS) (1,2) which predispose individuals to a variety of malignancies. I have no doubt that were he still alive today, his research interest would focus on chronic virus infections and ways to control or prevent disease by these viruses.

Keywords

Human Immunodeficiency Virus Herpes Simplex Virus Type Yellow Fever HCMV Infection Yellow Fever Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Barré-Sinoussi F, Chermann JC, Ray F, Nugeyre MT, Chamaret S, Gruest J, Dauguet C, Axler-Blin C, Vézine-Brun F, Rouzioux C, Rozenbaum W, Montagnier L. Science 220:868–871, 1983.PubMedCrossRefGoogle Scholar
  2. 2.
    Gallo RC, Sarin PS, Gelmann EP, Robert-Guroff M, Richardson E, Kalya-naraman VS, Mann D, Sidhu GD, Stahl RE, Zolla-Pazner S, Leibowitch J, Popovic M. Science 220:865–867, 1983.PubMedCrossRefGoogle Scholar
  3. 3.
    Ellermann V, Bang O. Zentralbl. Bakteriol., Parasitkde. Abt. I (Orig.) 46:595–609, 1908.Google Scholar
  4. 4.
    Rous P. J. Am. Med. Assoc. 56:198, 1911.Google Scholar
  5. 5.
    Theiler M, Smith HH. J. Exp. Med. 65:787–800, 1937.PubMedCrossRefGoogle Scholar
  6. 6.
    Sheldrick P, Berthelot N. Cold Spring Harbor Symp. Quant. Biol. 39: 667–678, 1975.PubMedGoogle Scholar
  7. 7.
    Honess RW, Roizman B. J. Virol. 14:8–19, 1974.PubMedGoogle Scholar
  8. 8.
    Buchman TG, Simpson T, Nosal C, Nahmias AJ. Ann. N.Y. Acad. Sci. 354:279–290, 1980.PubMedCrossRefGoogle Scholar
  9. 9.
    Kieff E, Hoyer B, Bachenheimer S, Roizman B. J. Virol. 9:738–745, 1972.PubMedGoogle Scholar
  10. 10.
    Wigdahl B, Scheck AC, Ziegler RJ, De Clercq E, Rapp F. J. Virol. 49: 426–436, 1984.PubMedGoogle Scholar
  11. 11.
    Wigdahl B, Smith CA, Traglia HM, Rapp F. Proc. Natl. Acad. Sci. USA 81:6217–6221, 1984.PubMedCrossRefGoogle Scholar
  12. 12.
    Wigdahl BL, Scheck AC, De Clercq E, Rapp H. Science 217:1145–1146, 1982.PubMedCrossRefGoogle Scholar
  13. 13.
    Wigdahl BL, Ziegler RJ, Sneve M, Rapp F. Virology 127:159–167, 1983.PubMedCrossRefGoogle Scholar
  14. 14.
    Colberg-Poley AM, Isom HC, Rapp F. Proc. Natl. Acad. Sci. USA 76: 5948–5951, 1979.PubMedCrossRefGoogle Scholar
  15. 15.
    Plotkin SA, Furukawa T, Zygraich N, Huygelen C. Infect. Immun. 12: 521–527, 1975.PubMedGoogle Scholar
  16. 16.
    Albrecht T, Rapp F. Virology 55:53–61, 1973.PubMedCrossRefGoogle Scholar
  17. 17.
    Takahashi M, Otsuka T, Okuno Y, Asano Y, Yazaki T, Isomura S. Lancet ii:1288–1290, 1974.CrossRefGoogle Scholar
  18. 18.
    Ciuffo G. Giornale Italiano delle Malattie Veneree 42:12–17, 1907.Google Scholar
  19. 19.
    Shope RE, Hurst EW. J. Exp. Med. 58:607–624, 1933.PubMedCrossRefGoogle Scholar
  20. 20.
    McCance DJ. Biochim. Biophys. Acta 823:195–205, 1986.PubMedGoogle Scholar
  21. 21.
    Koprowski H, DeFreitas EC, Harper ME, Sandberg-Wollheim M, Sheremata WA, Robert-Guroff M, Saxinger CW, Feinberg MB, Wong-Staal F, Gallo RC. Nature 318:154–160, 1985.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • F. Rapp
    • 1
  1. 1.Department of Microbiology, College of MedicineThe Pennsylvania State UniversityHersheyUSA

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