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Serological Arguments for Multiple Etiology of Visceral Larva Migrans

  • J. C. Petithory
  • F. Derouin
  • M. Rousseau
  • M. Luffau
  • M. Quedoc
Part of the Current Topics in Veterinary Medicine and Animal Science book series (CTVM, volume 43)

Abstract

The authors give five biological and epidemiological criteria for the diagnosis of Visceral Larva Migrans Syndrome (VLMS) as also the preliminary results of serodiagnostic tests using antigens of various nematodes, mainly Ascaris suum, Toxocara canis and Nippostrongylus brasiliensis.

Two hundred embryonated eggs of Toxocara canis were administered to “two mentally defective infants” by Smith and Beaver and they developed eosinophilia which persisted for more than 13 months (18). This experiment proved that T. canis larvae may be a cause of VLMS and fostered the idea that it was mostly if not only caused by T. canis (24–8).

A systematic study using numerous antigens of nematodes for serodiagnosis of VLMS allows us to give some supportive evidence in favour of the multiplicity of etiology of VLMS and of the partial role of T. canis.

Keywords

Cross Reaction Adult Worm Epidemiological Criterion Precipitin Band Ascaris Suum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Aubree P: Larva migrans viscerale: rôle de Ascaris suum. Thèse med., Paris 1973.Google Scholar
  2. 2.
    Beaver PC, Bowman DD: Ascaridoid larva (nematode) from the eye of a child in Uganda. American Journal of Tropical Medicine and Hygiene, 33, 1272–1274, 1984.PubMedGoogle Scholar
  3. 3.
    Biguet J, Rose F, Capron A, Tran Van Ky P: Contribution de l’analyse immunoélectrophoretique à la connaissance des antigènes vermineux. Incidences pratiques sur leur standardisation, leur purification et le diagnostic des helminthiases par immunoélectrophorèse. Revue d’Immunologie (Paris), 29, 5–23, 1965.Google Scholar
  4. 4.
    Canning GA: Precipitin reactions with various tissues of Ascaris lumbricoides and related helminths. American Journal of Hygiene, 9, 207–226, 1929.Google Scholar
  5. 5.
    Chabaud AG et Desset MC: Nippostrongylus rauschi n.sp.nematode parasite de dermoptères et considérations sur N.brasiliensis parasite cosmopolite des rats domestiques. Annales de Parasitologic (Paris), 41, 243–249, 1966.Google Scholar
  6. 6.
    Crewe W, Smith DH: Human infection with pig Ascaris (Ascaris suum). Annals of Tropical Medicine and Parasitology, 65, 85, 1971.PubMedGoogle Scholar
  7. 7.
    De Savigny DH: In vitro maintenance of Toxocara canis larvae and a simple method for the production of Toxocara ES antigen for use in serodiagnostic tests for visceral larva migrans. Journal of Parasitology, 61, 781–782, 1975.PubMedCrossRefGoogle Scholar
  8. 8.
    Ehrhard T, Kernbaum S: Toxocara canis et toxocarose humaine. Bulletin de l’Institut Pasteur, 77, 225–287, 1979.Google Scholar
  9. 9.
    Kazacos KR: Raccoon ascarids as a cause of larva migrans. Parasitology today, 2, 253–255, 1986.PubMedCrossRefGoogle Scholar
  10. 10.
    Longbottom JL, Pepys J: Pulmonary aspergillosis: diagnostic and immunological significance of antigens and C substance inAspergillus fumigatus. Journal of Pathology and Bacteriology, 88, 141–151, 1964.PubMedCrossRefGoogle Scholar
  11. 11.
    Luffau G: Propriétés biologiques du sérum hyperimmun provenant de rats infestés par Nippostrongylus brasiliensis. Annales de Recherches Vétérinaires, 3, 319–346, 1972.Google Scholar
  12. 12.
    Lysek H: Epidemiología y especificidad de la ascaridiosis en el hombre y el cerdo. Revista Cubana de Medicina Tropical, 26, 3–24, 1974.Google Scholar
  13. 13.
    Petithory J, Brumpt L: Diagnostic immunologique des filarioses. Nouvelle Presse médicale, 2, 2059, 1973.PubMedGoogle Scholar
  14. 14.
    Petithory J, Brumpt LC: Diagnostic d’une hyperéosinophilie parasitaire. Information médicale et paramédicale (Montreal), 28, 1–6, 1976.Google Scholar
  15. 15.
    Petithory JC, Lapierre J, Rousseau M, Clique MT: Diagnostic sérologique de l’anisakiase (granulome éosinophile digestif) par précipitation en milieu gélifié (Ouchterlony, électrosynérèse et immunoélectrophorèse). Médecine et Maladies Infectieuses, 3, 157–162, 1986.CrossRefGoogle Scholar
  16. 16.
    Petter C: Etude zoologique de la larva migrans. Annales de Parasitologie, 35, 118–137, 1960.Google Scholar
  17. 17.
    Phills JA, Harrold AJ, Whiteman GV, Perelmutter L: Pulmonary infiltrates, asthma and eosinophilia due to Ascaris suum infestation in man. New England Journal of Medicine, 286, 965–970, 1972.PubMedCrossRefGoogle Scholar
  18. 18.
    Smith MHD, Beaver PC: Persistance and distribution of toxocara larvae in tissues of children and mice. Pediatrics, 12, 491–497, 1953.PubMedGoogle Scholar
  19. 19.
    Sprent JFA: Observation on the development of Toxocara canis in the dog. Parasitology, 47, 184–209, 1957.CrossRefGoogle Scholar
  20. 20.
    Summer D, Tinsley EGF: Encephalopathy due to visceral larva migrans. Journal of Neurology, Neurosurgery and Psychiatry, 30, 580–584, 1967.CrossRefGoogle Scholar
  21. 21.
    Takata I: Experimental infection of man with ascaris of man and the pig. Kitasato Archives of Experimental Medicine, 23, 49–52, 1951.Google Scholar
  22. 22.
    Voelckel J, Le Gonidec G, Jacoby JC, Jehl R: Helminthes hépato digestifs parasites de rattus norvégiens à Marseille. Médecine Tropicale, 24, 531–536, 1964.PubMedGoogle Scholar
  23. 23.
    Williams JF, Soulsby EJL: Antigenic analysis of the developmental stages of Ascaris suum. I. Comparison of eggs, larvae and adults. Experimental Parasitology, 27, 150–162, 1970.PubMedCrossRefGoogle Scholar
  24. 24.
    Woodruff AW, Thacker CK: Infection with animal helminths. British Medical Journal, 1, 1001–1005, 1964.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • J. C. Petithory
  • F. Derouin
  • M. Rousseau
  • M. Luffau
  • M. Quedoc

There are no affiliations available

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