HLA-DR3 Molecules are the Products of an HLA Class II Immune Regulator Gene for Mycobacterium Leprae Predisposing to Tuberculoid Leprosy

  • Tom Ottenhoff
  • René De Vries
Chapter
Part of the Developments in Hematology and Immunology book series (DIHI, volume 17)

Abstract

Antigen specific immune responses are controlled by polymorphic immune response (Ir) genes. In experimental animals, the majority of these Ir genes has been mapped to the major histocompatibility complex, the MHC (1,2). MHC class II Ir genes have been found to control immune reactivity against T cell dependent foreign antigens. The products of these MHC class II Ir genes are the MHC class II molecules (1,2). Three major mechanisms of MHC class II Ir gene controlled interindividual variability in immune responsiveness have been described: a) differences in the available or selected T cell-antigen receptor repertoire b) differences in the capacity of class II molecules to associate with antigen in order to create an immunogenic complex for T cells, and c) differences in the activation of functionally distinct T cell compartments, e.g. suppressor (Ts) versus helper (Th) cells (2,3).

Keywords

Cell Responsiveness Cutaneous Leishmaniasis Mycobacterial Antigen Lepromatous Leprosy Mycobacterium Leprae 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • Tom Ottenhoff
    • 1
    • 2
  • René De Vries
    • 1
  1. 1.Department of Immunohematology and Blood BankUniversity HospitalLeidenThe Netherlands
  2. 2.Armauer Hansen Research InstituteAddis AbebaEthiopia

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