Disturbances in myocardial lipid homeostasis during ischemia and reperfusion

  • G. J. Van Der Vusse
  • F. W. Prinzen
  • R. S. Reneman
Chapter
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 70)

Abstract

Fatty acids are essential for myocardial functioning. They play a pivotal role as oxidizable substrates for cellular energy production. In addition, maintenance of the integrity of membrane phosphoglycerides, consisting in part of polyunsaturated fatty acids, is crucial for adequate cellular performance. Evidence is accumulating that the normal level of nonesterified fatty acids (NEFA) in normoxic cardiac tissue is extremely low, i.e. in the order of 20–50 nmol · g-1 wet weight. During ischemia, lasting for longer than 10 minutes, NEFA accumulated in the flow-deprived tissue. Accumulation was most outspoken in the subendocardial layers, if residual flow was below 0.3 ml · min-1 · g-1 wet weight and ATP levels dropped below 5–7 μmol · g-1 dry weight. Arachidonic acid showed the highest relative increase. A concomitant increase of lysophosphoglycerides has been measured. Arachidonic acid and lysophosphoglyceride levels decreased during the first 5 minutes of reperfusion following 60 minutes of ischemia, and tended to increase thereafter. The present findings clearly indicate that fatty acid homeostasis in myocardial tissue is disturbed during ischemia and reperfusion. Possible mechanisms underlying these derangements are discussed.

Keywords

Arachidonic Acid Myocardial Blood Flow Cholesteryl Ester Nonesterified Fatty Acid Subendocardial Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • G. J. Van Der Vusse
  • F. W. Prinzen
  • R. S. Reneman

There are no affiliations available

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