Monoclonal Antibodies in Lymphoma Diagnosis and Classification.
Abstract
The availability of monoclonal antibodies reactive with antigens present on leukocytes and leukocyte subpopulations has enabled a more reliable diagnosis and a more precise subclassification of malignant lymphomas. The wide application of monoclonal antibodies on frozen tissue sections makes one almost forget that the first monoclonal anti T cell reagents were described in 1979 (1), and the first applications of such antibodies on human lymph nodes by immunoperoxidase techniques were in 1981 (2). Since 1973 there had been a significant progress in the histological classification of malignant lymphomas, that was partly based on careful cytological comparisons between the cells of malignant lymphomas and of normal lymphoid tissues, an partly on the results of immunological marker studies, derived from basic imnunology (3, 4). Among these first immunological studies were the demonstration of complement receptors by rosetting techniques on frozen tissue sections of follicular lymphomas in 1974 (5) and the demonstration of cytoplasmic immunoglobulin by immunoperoxidase staining of paraffin tissue sections in 1974 (6).
Keywords
Malignant Lymphoma Hairy Cell Leukemia Hairy Cell Mantle Zone Freeze Tissue SectionPreview
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References
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