Experimental Results on Invasiveness of Mouse Mammary Cells: Clinical Implications?

  • Marc M. Mareel
  • Georges K. De Bruyne
  • Arnoud Sonnenberg
  • J. O. Hilgers
Chapter
Part of the Developments in Oncology book series (DION, volume 49)

Abstract

Multicellular organisms are characterized by the organization of their cells in domains building tissues and organs. Maintenance of the territorial integrity of these domains is under regulatory control not only during embryogenesis but also in adult life. Invasion can be defined as a loss of this territorial integrity: Invasive cells break through the boundary of their tissue of origin and penetrate into the territory of another tissue within the same or in another organ. Most invasive cells have the capacity to break through vessel walls and penetrate into the vessel lumen (intravasation). After transport by the circulation, invasive cells can leave the vessels (extravasation) and lodge at secondary sites to produce metastases. Since metastases are, like primary tumours, invasive, they put cells into a new (second, third, etc.) metastatic cascade.

Keywords

Invasive Cell Mouse Mammary Tumour Virus Mammary Cell Line Territorial Integrity Chick Heart 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barnett, S.C., Eccles, S.A. Studies of mammary carcinoma metastasis in a mouse model system. I. Derivation and characterization of cells with different metastatic properties during tumour progression in vivo. Clin. Exp. Metastasis 2, 15–35, 1984.PubMedCrossRefGoogle Scholar
  2. Dunn, T.B. Morphology of mammary tumors in mice. In: Homburger, F. (ed) The physiopathology of cancer, 2nd ed. Hoebner Inc., New York, 1958, pp 38–84.Google Scholar
  3. Dunnington, D.J., Hughes, C.M., Monaghan, P., Rudland, P.S. Phenotypic instability of rat mammary tumor epithelial cells. J. Natl. Cancer Inst. 71, 1227–1240, 1983.PubMedGoogle Scholar
  4. Fidler, I.J., Kripke, M.L. Metastasis results from pre-existing variant cells within a malignant tumor. Science 197, 893–895, 1977.PubMedCrossRefGoogle Scholar
  5. Hager, J.C., Fligiel, S., Stanley, W., Richardson, A.M., Heppner, G.H. Characterization of a variant-producing tumor cell line from a heterogeneous strain BALB/cfC3H mouse mammary tumor. Cancer Res.41, 1293–1300, 1981.PubMedGoogle Scholar
  6. Heppner, G.H. Tumor heterogeneity. Cancer Res. 44, 2259–2265, 1984.PubMedGoogle Scholar
  7. Kim, U. Factors influencing the generation of phenotypic heterogeneity in mammary tumours. In: Mihich, E. (ed) Biological responses in cancer, Vol. 3. Plenum Press, New York, 1986.Google Scholar
  8. Ling, V., Chambers, A.F., Harris, J.F., Hill, R.P. Quantitative genetic analysis of tumor progression. Cancer Metastasis Rev. 4, 173–194, 1985.PubMedCrossRefGoogle Scholar
  9. Mareel, M.M.K. The use of embryo organ cultures to study invasion in vitro. In: Liotta, L.A. and Hart, I.R. (eds) Tumor invasion and metastasis. Martinus Nijhoff Publ., The Hague, Boston, London, 1982, pp 207–230.CrossRefGoogle Scholar
  10. Mareel, M.M. Invasion in vitro: methods of analysis. Cancer Metastasis Rev. 2, 201–218, 1983.PubMedCrossRefGoogle Scholar
  11. Mareel, M.M., Van Roy, F.M. Are oncogenes involved in invasion and metastasis? Anticancer Res. 1986.Google Scholar
  12. Mareel, M.M., Bracke, M.E., Boghaert, E.R. Tumour invasion and metastasis: major causes of therapeutic failure. Radiotherapy and Oncology, 1986.Google Scholar
  13. Mareel, M., Kint, J., Meyvisch, C. Methods of study of the invasion of malignant C3H mouse fibroblasts into embryonic chick heart in vitro. Virchows Arch. (Cell Pathol.) 30, 95–111, 1979.Google Scholar
  14. Mareel, M., Bruyneel, E., De Bruyne, G., Dragonetti, C. Methods for morphological and biochemical analysis of invasion in vitro. In: De Brabander, M., Borgers, M., and De Mey, M. (eds) Cell movement and neoplasia. Pergamon Press, Oxford, New York, 1980, pp 87–95.Google Scholar
  15. McCrmack, S.A. Mixed cell populations in human mammary cancer. Rev. Endocrine-Related Cancer 17, 17–23, 1984.Google Scholar
  16. Poste, G. Tumor cell heterogeneity and the metastatic process. In: Rich, M.A., Hager, J.C., and Furmanski, P. (eds) Understanding breast cancer. Clinical and laboratory concepts. Marcel Dekker, Inc., New York and Basel, 1983, pp 119–143.Google Scholar
  17. Sonnenberg, A., Daams, J., Calafat, J., Hilgers, J. In vitro differentiation and progression of mouse mammary tumor cells. Cancer Res., 1986.Google Scholar

Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1986

Authors and Affiliations

  • Marc M. Mareel
    • 1
  • Georges K. De Bruyne
    • 1
  • Arnoud Sonnenberg
    • 2
  • J. O. Hilgers
    • 2
  1. 1.Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear MedicineUniversity HospitalGhentBelgium
  2. 2.Division of Tumor Biology, Antoni van LeeuwenhoekhuisThe Netherlands Cancer InstituteAmsterdamNetherlands

Personalised recommendations