Abstract
Acipimox is a nicotinic acid derivative which has a potent triglyceride (TG) lowering effect induced by sustained inhibition of adipose tissue lipolysis (Fuccella et al., 1980; Sirtori et al. 1981; Stirling et al., 1985). The reduced free fatty acid flux to the liver, and the consequent reduction of the precursor pool of very low density lipoprotein (VLDL)-triglycerides causes a diminution of VLDL synthesis and a consequent lowering of plasma triglycerides. Pantethine, defined as a natural hypolipidemic compound, is a vitamin derivative and precursor of Co-A which has been show to modulate serum lipids, mostly triglycerides, in type IV hyperlipoproteinemia (Avogaro et al., 1983; Da Col et al., 1984; Gaddi et al., 1984; Maggi et al., 1982).
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Capurso, A. et al. (1987). Effect of Acipimox on serum lipids and apoproteins in type II hyperlipoproteinemia. In: Lenzi, S., Descovich, G.C. (eds) Atherosclerosis and Cardiovascular Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3205-0_61
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DOI: https://doi.org/10.1007/978-94-009-3205-0_61
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7938-9
Online ISBN: 978-94-009-3205-0
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