Immunopathology of Ocular Inflammatory Disorders

  • S. Lightman
  • C.-C. Chan
Chapter
Part of the Immunology and Medicine Series book series (IMME, volume 13)

Abstract

Ocular inflammation can occur in patients with systemic disorders such as sarcoidosis and Behçet’s disease or can be localized to the eyes as in sympathetic ophthalmia and pars planitis. Many of these disorders have characteristic features that are recognizable clinically but whose causes are unknown. The patient often requires immunosuppressive therapy to control the inflammatory response so as to limit the damage to the ocular tissue. Autoimmune mechanisms are thought to be involved in the initiation and/ or perpetuation of the inflammatory response, although the exact role in the pathogenesis is unknown. With the advent of immunohistochemical staining with monoclonal antibodies to cell surface markers, much more is now known about the cell types infiltrating the inflamed eyes in these conditions.

Keywords

Retinal Pigment Epithelium Medicine Service Sympathetic Ophthalmia Experimental Autoimmune Uveoretinitis Streptococcal Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Kluwer Academic Publishers 1989

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  • S. Lightman
  • C.-C. Chan

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