Serotonin pp 411-416 | Cite as

Recent Insights into the Antihypertensive Mechanism of Action of Ketanserin

  • J. I. S. Robertson


Present evidence in man is clear and consistent in showing a minor or negligible role of α-1 antagonism in the antihypertensive action of ketanserin. An interaction between marked 5HT-2 and weak α-1 antagonism is by contrast a distinct possibility. The clinical role, if any, of ketanserin in depleting monoamine pools requires to be examined.


Essential Hypertension Antihypertensive Action Adrenergic Blockade Antihypertensive Mechanism Biogenic Amine Metabolite 
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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • J. I. S. Robertson
    • 1
    • 2
  1. 1.Prince of Wales HospitalChinese University of Hong KongShatin N.T.Hong Kong
  2. 2.Janssen Research FoundationBeerseBelgium

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