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Serotonin pp 411-416 | Cite as

Recent Insights into the Antihypertensive Mechanism of Action of Ketanserin

  • J. I. S. Robertson

Abstract

Present evidence in man is clear and consistent in showing a minor or negligible role of α-1 antagonism in the antihypertensive action of ketanserin. An interaction between marked 5HT-2 and weak α-1 antagonism is by contrast a distinct possibility. The clinical role, if any, of ketanserin in depleting monoamine pools requires to be examined.

Keywords

Essential Hypertension Antihypertensive Action Adrenergic Blockade Antihypertensive Mechanism Biogenic Amine Metabolite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • J. I. S. Robertson
    • 1
    • 2
  1. 1.Prince of Wales HospitalChinese University of Hong KongShatin N.T.Hong Kong
  2. 2.Janssen Research FoundationBeerseBelgium

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