Hypogammaglobulinaemia: Recent Advances

  • A. D. B. Webster
  • G. P. Spickett
Chapter
Part of the Immunology and Medicine Series book series (IMME, volume 8)

Abstract

Soon after the technology for serum protein electrophoresis became available, Bruton was able to diagnose a child with hypogammaglobulinaemia who probably had acquired disease rather than the inherited X-linked variety1. Janewayet al. 2 described more cases a few years later, showing that adults can also be affected. The Medical Research Council’s survey in the 1960s showed that the majority of patients in the UK acquired the disease as adults3. A rough estimate at present is that there are about 500 patients with ‘primary’ non-familial hypogammaglobulinaemia in the UK population of approximately 55 million, with about 50 males having definite X-linked disease. The term ‘primary’ is taken to mean that the hypogammaglobulinaemia is not associated with a lymphoid malignancy (e.g. chronic lymphatic leukaemia, myeloma) or has been induced by drugs. However, this terminology is likely to be superseded by a more descriptive classification (see Table 2.1). Selective deficiencies of IgG subclasses and of IgA are discussed in Chapter 5. Some patients with selective deficiencies of both IgA and IgG2 may be included under the broad classification of ‘primary’ hypogammaglobulinaemia if the total serum IgG is low.

Keywords

Human Immunodeficiency Virus Chronic Granulomatous Disease Rubella Virus Primary Immunodeficiency Disease Antibody Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Kluwer Academic Publishers 1988

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  • A. D. B. Webster
  • G. P. Spickett

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