Clinical Haemoperfusion

  • J. F. Winchester
Part of the New Clinical Applications Nephrology book series (NCNG, volume 6)

Abstract

Haemoperfusion, the direct contact of blood with sorbents within cartridges, has been used as an adjunct to dialysis for uraemia, and in drug intoxication, hepatic encephalopathy and for a variety of other conditions which will be outlined.

Keywords

Hepatic Encephalopathy Activate Charcoal Fulminant Hepatic Failure Hepatic Coma Poison Control Center 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Yatzidis, H. (1964). A convenient haemoperfusion micro-apparatus over charcoal for the treatment of endogenous and exogenous intoxications. Its use as an artifical kidney. Proc. Eur. Dial. Transplant. Assoc., 1, 83Google Scholar
  2. 2.
    Dunea, G. and Kolff, W. J. (1965). Clinical experience with the Yatzidis charcoal artifical kidney. Trans. Am. Soc. Artif. Intern. Organs, 11, 178PubMedGoogle Scholar
  3. 3.
    Chang, T. M. S. (1966). Semipermeable aqueous microcapsules (artificial cells): with emphasis on experiments in an extracorporeal shunt system. Trans. Am. Soc. Artif. Intern. Organs, 12, 13PubMedGoogle Scholar
  4. 4.
    Denti, E., Luboz, M. P. and Tessore, V. (1975). Adsorption characteristics of cellulose acetate coated charcoals. J. Biomed. Mater. Res., 9, 143PubMedCrossRefGoogle Scholar
  5. 5.
    Cornelis, R., Ringoir, S., Mees, L. and Hoste, J. (1980). Behaviour of trace metals during hemoperfusion. Mineral Electrol. Metab., 4, 123Google Scholar
  6. 6.
    Hagstam, K. E., Larsson, L. E. and Thysell, H. (1966). Experimental studies on charcoal haemoperfusion in phenobarbital intoxication and uraemia, including histopathologic findings. Acta Med. Scand., 180, 593PubMedCrossRefGoogle Scholar
  7. 7.
    Winchester, J. F. (1980). Hemoperfusion in uremia. In Giordano, C. (eds.) Sorbents and Their Clinical Applications, p. 387. (New York: Academic Press Inc.)Google Scholar
  8. 8.
    Chang, T. M. S. (1978). Microcapsule artificial kidney in replacement of renal function. With emphasis on adsorbent hemoperfusion. In Drukker, W., Parsons, F. M. and Maher, J. F (eds.). Replacement of Renal Function by Dialysis, p. 217. First Edition, (The Hague, Boston, London: Martinus Nijhoff Publishers)Google Scholar
  9. 9.
    Stefoni, S., Feliciangeli, G., Coli, L. and Bonomini, V. (1979). Evaluation of a new coated charcoal for hemoperfusion in uremia. Int. J. Artif. Organs., 2, 320PubMedGoogle Scholar
  10. 10.
    Pott, G., Voss, B., Lohmann, J. and Zundorf, P. (1982). Loss of fibronectin in plasma of patients with shock and septicaemia, and after haemoperfusion in patients with severe poisoning. J. Clin. Chem. Clin. Biochem., 20, 333PubMedGoogle Scholar
  11. 11.
    Winchester, J. F., Ratcliffe, J. G., Carlyle, E. and Kennedy, A. C. (1978). Solute, amino acid, and hormone changes with coated charcoal hemoperfusion in uremia. Kidney Int., 14, 74PubMedCrossRefGoogle Scholar
  12. 12.
    Gimson, A. E. S., Langley, P. G., Hughes, R. D, Canalese, J., Mellon, P. G., Williams, R., Woods, H. F. and Weston, M. J. (1980). Prostacyclin to prevent platelet activation during charcoal haemoperfusion in fulminant hepatic failure. Lancet, 1, 173PubMedCrossRefGoogle Scholar
  13. 13.
    Muirhead, E. E. and Reid, A. F. (1984). Resin artificial kidney. J. Lab. Clin. Med., 33, 841Google Scholar
  14. 14.
    Yatzidis, H., Voudiclari, S., Oreopoulos, D., Tsaparas, N., Triantaphyllidis, D., Gavras, C. and Stavroulaki, A. (1965). Treatment of severe barbiturate poisoning. Lancet, 2, 216CrossRefGoogle Scholar
  15. 15.
    Chang, T. M. S., Gonda, A., Dirks, J. H. and Malave, N. (1971). Clinical evaluation of chronic intermittent and short term hemoperfusion in patients with chronic renal failure using semipermeable microcapsules (artificial cells) formed from membrane coated activated charcoal. Trans. Am. Soc. Artif Intern. Organs., 17, 246PubMedGoogle Scholar
  16. 16.
    Chang, T. M. S. and Migchelsen, M. (1973) Characterization of possible ‘toxic’ metabolites in uremia and hepatic coma based on the clearance spectrum for larger molecules by the ACAC microcapsule artificial kidney. Trans. Am. Soc. Artif. Intern. Organs, 19, 314PubMedGoogle Scholar
  17. 17.
    Chang, T. M. S., Migchelsen, M., Coffey, J. F. and Stark, R. (1974). Serum middle molecule levels in uremia during long term intermittent hemoperfusion with ACAC (coated charcoal) microcapsule artificial kidney. Trans. Am. Soc. Artif. Intern. Organs., 20, 364Google Scholar
  18. 18.
    Odaka, M., Hirasawa, H., Kobayashi, H., Ohkawa, M., Soeda, K., Tabata, Y., Soma, M. and Sato, H. (1980). Clinical and fundamental studies of cellulose coated bead-shaped charcoal haemoperfusion in chronic renal failure. In Sideman, S. and Chang, T. M. S. (eds.) Hemoperfusion, Kidney and Liver Support and Detoxification, p. 45. (Washington DC: Hemisphere Publishing Corp.)Google Scholar
  19. 19.
    Trznadel, K., Luciak, M. and Wyszogrodzka, M. (1981). Effect of haemoperfusion on the left ventricular systolic function in patients with chronic uraemia. Acta Med. Pol., 22, 75PubMedGoogle Scholar
  20. 20.
    Stefoni, S., Coli, L., Feliciangeli, G., Baldrati, L. and Bonomini, V. (1980). Regular hemoperfusion in regular dialysis treatment. A long-term study. Int. J. Artif. Organs, 3, 348PubMedGoogle Scholar
  21. 21.
    Otsubo, O., Kuzuhara, K., Simada, Y., Yamauchi, Y., Takahashi, I., Yamada, Y., Otsubo, K. and Inou, T. (1979) Treatment of uraemic peripheral neuritis by direct haemoperfusion with activated charcoal. Proc. Eur. Dial. Transplant Assoc., 16, 731PubMedGoogle Scholar
  22. 22.
    Chang, T. M. S., Barre, P. and Kuruvilla, S. (1985). Long-term reduced time hemoperfusion-hemodialysis compared to standard dialysis. A preliminary crossover analysis. Trans. Am. Soc. Artif. Intern. Organs, 31, 572PubMedGoogle Scholar
  23. 23.
    Henderson, I. S. and Kennedy, A. C. (1984). Long-term evaluation of charcoal haemoperfusion combined with dialysis for uraemic patients. In Paul, J. P., Gaylor, J. D. S., Courtney, J. M., Gilchrist, T. (eds.) Biomaterials in Artificial Organs, p. 72. (London and Basingstoke: The Macmillan Press Ltd.)Google Scholar
  24. 24.
    Bonomini, V., Stefoni, S., Feliciangeli, G., Coli, L., Scolari, M. P., Prandini, R., Casciani, C. U., Taccone Gallucci, Albertazzi, A., Mioli, V., Mastrangelo, F. (1984). Present status of hemoperfusion/hemodialysis in Italy. Appl. Biochem. Biotechnol., 10, 157PubMedCrossRefGoogle Scholar
  25. 25.
    Barre, P. E., Gonda, A. and Chang, T. M. S. (1986). Routine clinical applications of hemodialysis-hemoperfusion in chronic renal failure: case reports. Int. J. Artif. Organs, 9, 305PubMedGoogle Scholar
  26. 26.
    Vale, J. A., Meredith, T. and Buckley, B. (1984). ABC of poisoning. Eliminating poisons. Br. Med. J., 289, 366CrossRefGoogle Scholar
  27. Litovitz, T. and Veltri, J.(1985). 1984 annual report of the American Association of Poison Control Centers. Am. J. Emerg. Med., 3, 423PubMedCrossRefGoogle Scholar
  28. 28.
    Henry, J. A. and Cassidy, S. L. (1986). Membrane stabilising ability: A major cause of fatal poisoning. Lancet, 1, 1414PubMedCrossRefGoogle Scholar
  29. 29.
    Litovitz, T. L., Normann, S. A. and Veltri, J. C. (1986). 1985 annual report of the American Association of Poison Control Centers National Data Collection System. Am. J. Emerg. Med., 4, 427PubMedCrossRefGoogle Scholar
  30. 30.
    Haddad, L. M. (1986). A general approach to poisoning. In Winchester, J. F. (ed.) Office Procedures: Office Management of Poisoning, p. 325. (Philadelphia: Hanley and Belfus Inc.)Google Scholar
  31. 31.
    Clemmesen, C. and Nilsson, E. (1961). Therapeutic trends in the treatment of barbiturate poisoning: The Scandinavian method. Clin. Pharmacol. Ther., 2, 220PubMedGoogle Scholar
  32. 32.
    Winchester, J. F., Gelfand, M. C. and Tilstone, W. J. (1978). Hemoperfusion in drug intoxication — Clinical and laboratory aspects. Drug Metab. Rev., 8, 69PubMedCrossRefGoogle Scholar
  33. 33.
    Winchester, J. F., Gelfand, M. C., Knepshield, J. H. and Schreiner, G. E. (1977). Dialysis and hemoperfusion of poisons and drugs — Update. Trans. Am. Soc. Artif. Intern. Organs, 23, 762PubMedGoogle Scholar
  34. 34.
    Rosenbaum, J. L., Kramer, M. S., Raja, R. M., Krug, M. J. and Bolisay, C. G. (1980). Current status of hemoperfusion in toxicology.Clin. Toxicol., 17, 493PubMedCrossRefGoogle Scholar
  35. 35.
    Winchester, J. F., Tilstone, W. J., Edwards, R. O., Gilchrist, T. and Kennedy, A. C. (1974). Hemoperfusion for enhanced drug elimination — A kinetic analysis in paracetamol poisoning. Trans. Am. Soc. Artif. Intern. Organs, 20, 358Google Scholar
  36. 36.
    Pond, S., Rosenberg, J., Benowitz, N. L. and Takki, S. (1979). Pharmacokinetics of haemoperfusion in drug overdose. Clin. Pharmacokinet., 4, 329PubMedCrossRefGoogle Scholar
  37. 37.
    Cutler, R. E., Forland, S. C., St John Hammond, P. G. and Evans, R. J. (1987). Extracorporeal removal of drugs and poisons by hemodialysis and hemoperfusion. Ann. Rev. Pharmacol. Toxicol., 27, 169CrossRefGoogle Scholar
  38. 38.
    Lorch, J. A. and Garella, S. (1979). Hemoperfusion to treat intoxications. Ann. Intern. Med., 91, 301PubMedGoogle Scholar
  39. 39.
    Uldall, P. R. (1982). Controlled trial of resin hemoperfusion for the treatment of drug overdose at Toronto Western Hospital (TWH). Trans. Am. Soc. Artif. Intern. Organs, 28, 676Google Scholar
  40. 40.
    Winchester, J. F. (1983). Active methods for detoxification: Oral sorbents, forced diuresis, hemoperfusion, and hemodialysis. In Haddad, L. M. and Winchester, J. F. (eds.) Clinical Management of Poisoning and Drug Overdose, p. 154. (Philadelphia: W. B. Saunders Co.)Google Scholar
  41. 41.
    Gazzard, B. G., Willson, R. A., Weston, M. J., Thompson, R. and Williams, R., (1974). Charcoal haemoperfusion for paracetamol overdose. Br. J. Clin. Pharmacol., 1, 217Google Scholar
  42. 42.
    Winchester, J. F., Gelfand, M. C., Helliwell, M., Vale, J. A., Goulding, R. and Schreiner, G. E. (1981). Extracorporeal treatment of salicylate or acetaminophen poisoning — Is there a role? Arch. Intern. Med., 141, 370PubMedCrossRefGoogle Scholar
  43. 43.
    Diaz-Buxo, J. A., Farmer, C. D. and Chandler, T. Y. (1978). Hemoperfusion in the treatment of amitriptyline poisoning. Trans. Am. Soc. Artif. Intern. Organs, 24, 699PubMedGoogle Scholar
  44. 44.
    Trafford, J. A. P., Jones, R. H., Evans, R., Sharp, P., Sharpstone, P. and Cook, J. (1977). Haemoperfusion with R-004 amberlite resin for treating acute poisoning. Br. Med. J., 2, 1453PubMedCrossRefGoogle Scholar
  45. 45.
    Crome, P., Braithwaite, R. A., Widdop, B. and Medd, R. K. (1980). Haemoperfusion in clinical and experimental tricyclic antidepressant poisoning. In Sideman, S. and Chang, T. M. S. (eds.) Hemoperfusion, Kidney and Liver Support and Detoxification, p. 301. (Washington DC: Hemisphere Publishing Corp.)Google Scholar
  46. 46.
    Hoy, W. E., Gibson, T. P., Rivero, A. J., Jain, J. K., Talley, T. T., Bayer, R. M., Montondo, D. F. and Freeman, R. B. (1983). XAD-4 resin hemoperfusion for digitoxic patients with renal failure. Kidney Int., 23, 79PubMedCrossRefGoogle Scholar
  47. 47.
    Wenger, T. L., Butler, V. P. Jr, Haber, E. and Smith, T. W. (1985). Treatment of 63 severely digitalis-toxic patients with digoxin specific antibody fragments. J. Am. Coll. Cardiol., 5, (5 Suppl A), 118ACrossRefGoogle Scholar
  48. 48.
    Maini, R. and Winchester, J. F. (1975). Removal of paraquat from blood by haemoperfusion over sorbent materials. Br. Med. J., 3, 281PubMedCrossRefGoogle Scholar
  49. 49.
    Mascie-Taylor, B. H., Thompson, J. and Davison, A. M. (1983). Haemoperfusion ineffective for paraquat removal in life-threatening poisoning. Lancet, 1, 1376PubMedCrossRefGoogle Scholar
  50. 50.
    Okonek, S., Baldamus, C. A., Hofman, A., Schuster, C. J., Bechstein, P. B. and Zoller, B. (1979). Two survivors of severe paraquat intoxication by ‘continuous hemoperfusion.’ Klin. Wochenshr., 57, 957CrossRefGoogle Scholar
  51. 51.
    Gelfand, M. C., Winchester, J. F., Knepshield, J. H., Hanson, K. M., Cohan, S. L., Strauch, B. S., Geoly, K. L., Kennedy, A. C. and Schreiner, G. E. (1977). Treatment of severe drug overdose with charcoal hemoperfusion. Trans. Am. Soc. Artif Intern. Organs, 23, 599PubMedGoogle Scholar
  52. 52.
    Connell, J. M., McGeachie, J. F., Knepil, J., Thomson, A. and Junor, B. (1982). Self-poisoning with sustained-release aminophylline: secondary rise in serum theophylline concentration after charcoal haemoperfusion.Br. Med. J., 284, 943CrossRefGoogle Scholar
  53. 53.
    Ahlmen, J., Heath, A., Herlitz, H., Kvist, L. and Mellstrand, T. (1984). Treatment of oral theophylline poisoning. Acta Med. Scand., 216, 423PubMedGoogle Scholar
  54. 54.
    Chang, T. M. S. and Barre, P. (1983). Effect of desferrioxamine on removal of aluminium and iron by coated charcoal haemoperfusion and haemodialysis. Lancet, 2, 1051PubMedCrossRefGoogle Scholar
  55. 55.
    Winchester, J. F. (1986). Management of iron overload. Semin. Nephrol., 4, (suppl. 1), 22Google Scholar
  56. 56.
    Andress, D. L., Maloney, N. A., Endres, D. B. and Sherrard, D. J. (1986). Aluminium-associated bone disease in chronic renal failure: high prevalence in a long-term dialysis population. J. Bone Miner. Res., 1, 391PubMedCrossRefGoogle Scholar
  57. 57.
    Arieff, A. I. (1985). Aluminium and the pathogenesis of dialysis encephalopathy. Am. J. Kidney Dis., 6, 317PubMedGoogle Scholar
  58. 58.
    Bregman, H., Gelfand, M. C., Winchester, J. F., Manz, H. J., Knepshield, J. H. and Schreiner, G. E. (1980). Iron overload-associated myopathy in patients on maintenance haemodialysis. A histocompatibility linked disorder. Lancet, 2, 882PubMedCrossRefGoogle Scholar
  59. 59.
    Marcus, R. E., Davies, S. C., Bantock, H. M., Underwood, S. R., Walton, S. and Huehns, E. R. (1984). Desferrioxamine to improve cardiac function in iron overloaded patients with thalassemia major. Lancet, 1, 392PubMedCrossRefGoogle Scholar
  60. 60.
    Lund, M. E., Banner, W., Clarkson, T. W. and Berlin, M. (1984). Treatment of acute methylmercury ingestion by hemodialysis with n-acetylcysteine (Mucomyst) infusion and 2, 3-dimercaptopropane sulfonate. J. Toxicol Clin. Toxicol., 22, 31PubMedCrossRefGoogle Scholar
  61. 61.
    Al-Abassi, A. H., Kostyniak, P. J. and Clarkson, T. W. (1978). An extracorporeal complexing hemodialysis system for the treatment of methylmercury poisoning. III Clinical applications. J. Pharmacol Exp. Ther., 207, 249Google Scholar
  62. 62.
    Margel, S. (1981). A novel approach for heavy metal poisoning treatment, a model. Mercury poisoning by means of chelating microspheres; hemoperfusion and oral administration. Med. Chem., 24, 1263CrossRefGoogle Scholar
  63. 63.
    James, J. H., Ziparo, V., Jeppson, B. and Fischer, J. E. (1979). Hyperammonaemia, plasma aminoacid imbalance, and blood-brain aminoacid transport: A unified theory of portal-systemic encephalopathy. Lancet, 2, 772PubMedCrossRefGoogle Scholar
  64. 64.
    Schafer, D. F. and Jones, E. A. (1982). Hepatic encephalopathy and the gammaaminobutyric-acid neurotransmitter system. Lancet, 1, 18PubMedCrossRefGoogle Scholar
  65. 65.
    Chang, T. M. S. (1972). Haemoperfusion over microencapsulated adsorbent in a patient with hepatic coma. Lancet, 2, 1371PubMedCrossRefGoogle Scholar
  66. 66.
    Gazzard, B. G., Portmann, B. A., Weston, M. J., Langley, P. G., Murray-Lyon, I. M., Dunlop, E. H., Flax, H., Mellon, P. J., Record, C. O., Ward, M. B. and Williams, R. (1974). Charcoal haemoperfusion in the treatment of fulminant hepatic failure. Lancet, 1, 1301PubMedCrossRefGoogle Scholar
  67. 67.
    Silk, D. B. A. and Williams, R. (1980). Sorbents in hepatic failure. In Giordano, C. (ed.) Sorbents and Their Clinical Applications, p. 415. (New York: Academic Press Inc.)Google Scholar
  68. 68.
    Chang, T. M. S., Lister, C., Chirito, E., O’Keefe, P., Resurrección, E. (1978). Effects of hemoperfusion rate and time of initiation of ACAC charcoal hemoperfusion on the survival of fulminant hepatic failure rats. Trans. Am. Soc. Artif. Intern. Organs, 24, 243PubMedGoogle Scholar
  69. 69.
    Gimson, A. E. S., Braude, S., Mellon, P. J., Canalese, J. and Williams, R. (1982). Earlier charcoal haemoperfusion in fulminant hepatic failure. Lancet, 2, 681PubMedCrossRefGoogle Scholar
  70. 70.
    Tygstrup, N. and Ranek, L. (1986). Fulminant hepatic failure. Clin. Gastroenterol., 10, 191Google Scholar
  71. 71.
    Hughes, R. D., Cochrane, A. M. D., Thomson, A. D., Murray-Lyon and Williams, R. (1976). Cytotoxicity of plasma from patients with acute hepatic failure to isolated rabbit hepatocytes. Br. J. Exp. Pathol., 57, 348PubMedGoogle Scholar
  72. 72.
    Seda, H. W. M., Hughes, R. D., Give, C. D. and Williams, R. (1984). Removal of inhibitors of brain Na+ K+ ATPase by haemoperfusion in fulminant hepatic failure. Artif. Organs, 8, 174PubMedCrossRefGoogle Scholar
  73. 73.
    Woods, H. F., Weston, M. J., Bunting, S., Moncada, S. and Vane, J. (1980). Prostacyclin eliminates the thrombocytopenia associated with charcoal hemoperfusion and minimizes heparin and fibrinogen consumption. Artif. Organs, 4, 176PubMedCrossRefGoogle Scholar
  74. 74.
    Rubin, M. H., Weston, M. J., Bullock, G., Roberts, J., Langley, P. G., White, Y. S. and Williams, R. (1977). Abnormal platelet function and ultrastructure in fulminant hepatic failure. Q. J. Med., 46, 339PubMedGoogle Scholar
  75. 75.
    Gelfand, M. C., Winchester, J. F., Knepshield, J. H., Cohan, S. I. and Schreiner, G. E. (1978). Reversal of hepatic coma by coated charcoal hemoperfusion: Clinical and biochemical observations, asaio J., 1, 73Google Scholar
  76. 76.
    Kennedy, H. J., Greaves, M. and Triger, D. R. (1985). Clinical experience with the use of charcoal haemoperfusion: Is prostacyclin required? Life Support Syst., 3, 15Google Scholar
  77. 77.
    Berk, P. D. (1977). A computer simulation study relating to the treatment of fulminant hepatic failure by hemoperfusion. Proc. Soc. Exp. Biol. Med., 155, 535PubMedGoogle Scholar
  78. 78.
    Bihari, D., Hughes, R. D., Gimson, A. E. S., Langley, P. G., Ede, R. J., Eder, G. and Williams, R. (1983). Effects of serial resin haemoperfusion in fulminant hepatic failure. Int. J. Artif. Organs, 6, 299PubMedGoogle Scholar
  79. 79.
    Hughes, R. and Williams, R. (1986). Clinical experience with charcoal and resin hemoperfusion. Semin. Liver Dis., 6, 164PubMedCrossRefGoogle Scholar
  80. 80.
    Wagemaker, H. and Cade, R. (1977). The use of hemodialysis in chronic schizophrenia.Am. J. Psychiatr., 134, 684PubMedGoogle Scholar
  81. 81.
    Chang, T. M. S. (1978). Hemoperfusion in chronic schizophrenia. Int. J. Artif. Organs, 1, 253PubMedGoogle Scholar
  82. 82.
    Nedipil, N., Dieterle, D. and Gurland, H. Y. (1980). Blood purification treatment of schizophrenia. Int. J. Artif. Organs, 3, 76Google Scholar
  83. 83.
    Schulz, S. C., VanKammen, D. P., Balow, J. E., Flye, N. W. and Bunney, W. E. (1981). Dialysis in schizophrenia: A double blind evaluation. Science, 211, 1066PubMedCrossRefGoogle Scholar
  84. 84.
    Nissensson, A. B., Rapaport, M., Gordon, A. and Narins, R. G. (1978). Controlled study demonstrates that psoriasis is not improved by haemodialysis. Kidney Int., 14, 682Google Scholar
  85. 85.
    Maeda, K., Asada, H., Yamamoto, Y. and Ohta, K. (1980). Psoriasis treatment with direct hemoperfusion. In Sideman, S. and Chang, T. M. S. (eds.) Hemoperfusion, Kidney and Liver Support and Detoxification, p. 349. (Washington DC: Hemisphere Publishing Corp.)Google Scholar
  86. 86.
    Winchester, J. F., Rahman, A., Bregman, H., Mortensen, L. M., Gelfand, M. C., Schein, P. S. and Schreiner, G. E. (1980). Role of hemoperfusion in anticancer drug removal. In Sideman, S. and Chang, T. M. S. (eds.) Hemoperfusion, Kidney and Liver Support and Detoxification, p. 369. (Washingon DC: Hemisphere Publishing Corp.)Google Scholar
  87. 87.
    Hande, K. R., Balow, J. E., Draje, J. C., Rosenberg, S. A. and Chabner, B. A. (1977). Methotrexate and hemodialysis. Ann. Intern. Med., 87, 496Google Scholar
  88. 88.
    Molina, R., Fabian, C. and Cowley, B. Jr (1987). Use of charcoal hemoperfusion to reduce serum methotrexate levels in a patient with acute renal insufficiency. Am. J. Med., 82, 350PubMedCrossRefGoogle Scholar
  89. 89.
    Winchester, J. F., Rahman, A., Tilstone, W. J., Kessler, A., Mortensen, L., Schreiner, G. E. and Schein, P. S. (1979). Sorbent removal of adriamycin in vitro and in vivo. Cancer Treat. Rep., 63, 1787PubMedGoogle Scholar
  90. 90.
    Oldfield, E. H., Dedrick, R. L., Yeager, R. L., Clark, W. C., DeVroom, H. L., Chatterji, D. C. and Doppman, J. L. (1985). Reduced systemic drug exposure by continuous intra-arterial chemotherapy with hemoperfusion of regional venous drainage.J. Neurosurg., 163, 726–732Google Scholar
  91. 91.
    Terman, D. S. (1980). Extracorporeal immunoadsorbents for extraction of circulation immune reactants. In Giordano, C. (ed.) Sorbents and Their Clinical Applications, p. 470. (New York: Academic Press Inc.)Google Scholar
  92. 92.
    Terman, D. S., Buffaloe, G., Mattioli, C., Cook, G., Tillquist, R., Sullivan, M. and Ayus, J. C. (1979). Extracorporeal immunoabsorption: Initial experience in human systemic lupus erythematosus. Lancet, 2, 824PubMedCrossRefGoogle Scholar
  93. 93.
    Terman, D. S., Yamamoto, T., Mattioli, M., Cook, G., Tillquis, R., Henry, J., Poser and Daskal, Y. (1980). Extensive necrosis of spontaneous canine mammary adenocarcinoma after extracorporeal perfusion over staphylococcus aureus Cowans I. J. Immunol., 124, 795PubMedGoogle Scholar
  94. 94.
    Terman, D. S. and Bertram, J. H. (1985). Antitumor effects of immobilized protein A and Staphylococcal products: Linkage between toxicity and efficacy and tumoricidal reagents. Eur. J. Cancer Clin. Oncol., 21, 1115PubMedCrossRefGoogle Scholar
  95. 95.
    Savin, H., Marcus, L., Margel, S., Ofarim, M. and Ravid, M. (1987). Treatment of adverse digitalis effects of hemoperfusion through columns with antidigoxin antibodies bound to agarose polyacrolein microsphere beads. Am. Heart J., 113, 1078PubMedCrossRefGoogle Scholar
  96. 96.
    Chang, T. M. S. and Nicolaev, V. G. (1987). Hemoperfusion, sorbents and immobilized bioreactants. Biomater. Artif. Cells Artif. Organs, 15, (special issue)Google Scholar
  97. 97.
    Silk, D. B. A. and Williams, R. (1978). Experiences in the treatment of fulminant hepatic failure by conservative therapy, charcoal haemoperfusion and poly-acrylonitrile haemodialysis. Int. J. Artif. Organs, 1, 29PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • J. F. Winchester

There are no affiliations available

Personalised recommendations