Template Synthesis of Ligands for Highly Charged Metal Cations
Macrocyclic and macrobicyclic ligands may enhance the stability of their metal complexes due to the inherent entropic and kinetic properties of a ligand ring or cage-type structure. In general, as the binding site becomes more encapsulated or preformed the reorganization entropy decreases, leading to a relatively higher formation constant for metal binding. Thus it would be expected that the formation constants be greatest for the series macrobicyclic > macrocyclic > exocyclic (Figure 1).
KeywordsMetal Binding Kinetic Property Acetonitrile Solution Template Synthesis Macrocyclic Ligand
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- 2.T. J. McMurry, M. W. Hosseini, T. M. Garrett, F. E. Hahn, Z. E. Reyes, and K. N. Raymond: J. Am. Chem. Soc. in press.Google Scholar