Clinical Studies with the Nal-Glu GnRH Antagonist

  • Ph. Bouchard
  • S. Hajri
  • N. Lahlou
  • M. Roger
  • S. Brailly
  • S. Dubourdieu
  • R. Frydman
  • B. Charbonnel
  • S. Delivet
  • G. Schaison
  • Y. Y. Tsong
  • I. M. Spitz

Abstract

Because of the existence of anaphylactoid side effects following the subcutaneous (sc) injection of first generation antagonists of the [D-Arg6] class, there have been few clinical trials using GnRH antagonists in humans. These agents cause mast cell degranulation and histamine release [1, 2]. Recently, new classes of compounds have been designed and are available for phase 1 clinical trials.

Keywords

Luteal Phase GnRH Agonist Follicular Phase GnRH Antagonist Dominant Follicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Ph. Bouchard
    • 1
    • 2
    • 3
    • 4
    • 5
  • S. Hajri
    • 1
    • 2
    • 3
    • 4
    • 5
  • N. Lahlou
    • 1
    • 2
    • 3
    • 4
    • 5
  • M. Roger
    • 1
    • 2
    • 3
    • 4
    • 5
  • S. Brailly
    • 1
    • 2
    • 3
    • 4
    • 5
  • S. Dubourdieu
    • 1
    • 2
    • 3
    • 4
    • 5
  • R. Frydman
    • 1
    • 2
    • 3
    • 4
    • 5
  • B. Charbonnel
    • 1
    • 2
    • 3
    • 4
    • 5
  • S. Delivet
    • 1
    • 2
    • 3
    • 4
    • 5
  • G. Schaison
    • 1
    • 2
    • 3
    • 4
    • 5
  • Y. Y. Tsong
    • 1
    • 2
    • 3
    • 4
    • 5
  • I. M. Spitz
    • 1
    • 2
    • 3
    • 4
    • 5
  1. 1.Service d’ Endocrinologie et des Maladies de la ReproductionHôpital BicêtreFrance
  2. 2.Maternité Hôpital A. BeclèreFrance
  3. 3.Hotel Dieu de NantesFrance
  4. 4.Fondation de Recherche en HormonologieFrance
  5. 5.Population CouncilNew YorkUSA

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