Imaging Thrombus with Radiolabelled Monoclonal Antibody to Platelets

  • J. P. Lavender
  • A. M. Peters
  • A. W. J. Stuttle
  • S. G. Needham
  • I. Loutfi
  • D. Snook
  • A. A. Epenetos
  • P. Lumley
  • R. J. Keery
  • N. Hogg
Part of the Developments in Nuclear Medicine book series (DNUM, volume 17)

Abstract

Indium-III labelled platelets introduced in the late 1970’s as a new method of imaging thrombus have not gained widespread use and conventional radiographic techniques such as contrast phlebography for deep venous thrombosis remain as the favoured diagnostic approaches. The main drawback of Indium-III labelled platelets is the time and technical skill required for cell separation and labelling and this has resulted in only a few regional centres making use of this technique. Oster et al have demonstrated the possibility of labelling platelets by the use of a radiolabelled monoclonal antibody in the dog and we have recently explored this technique in man.

Keywords

Deep Venous Thrombosis Platelet Rich Plasma Receptor Occupancy IgG1 Mouse Monoclonal Antibody Spontaneous Aggregation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Oster Z.M., Srivastava S.C., Som P. et al. (1985) Thrombus radioimmuno-scintigraphy: an approach using monoclonal anti platelet antibody. Proc. Natl. Acad. Sci. U.S.A. 82: 3465–8.PubMedCrossRefGoogle Scholar
  2. 2.
    Peters A.M., Lavender J.P., Needham S.G. et al. (1986) Imaging thrombus with radiolabelled monoclonal antibody to platelets. Br. Med. J. 293: 1525–27.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • J. P. Lavender
    • 1
    • 2
    • 3
  • A. M. Peters
    • 1
    • 2
    • 3
  • A. W. J. Stuttle
    • 1
    • 2
    • 3
  • S. G. Needham
    • 1
    • 2
    • 3
  • I. Loutfi
    • 1
    • 2
    • 3
  • D. Snook
    • 1
    • 2
    • 3
  • A. A. Epenetos
    • 1
    • 2
    • 3
  • P. Lumley
    • 1
    • 2
    • 3
  • R. J. Keery
    • 1
    • 2
    • 3
  • N. Hogg
    • 1
    • 2
    • 3
  1. 1.Department of Diagnostic RadiologyHammersmith HospitalLondonUK
  2. 2.Glaxo Group Research Ltd.UK
  3. 3.Imperial Cancer Research FundLondonUK

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