Imaging Thrombus with Radiolabelled Monoclonal Antibody to Platelets
Indium-III labelled platelets introduced in the late 1970’s as a new method of imaging thrombus have not gained widespread use and conventional radiographic techniques such as contrast phlebography for deep venous thrombosis remain as the favoured diagnostic approaches. The main drawback of Indium-III labelled platelets is the time and technical skill required for cell separation and labelling and this has resulted in only a few regional centres making use of this technique. Oster et al have demonstrated the possibility of labelling platelets by the use of a radiolabelled monoclonal antibody in the dog and we have recently explored this technique in man.
KeywordsDeep Venous Thrombosis Platelet Rich Plasma Receptor Occupancy IgG1 Mouse Monoclonal Antibody Spontaneous Aggregation