Chemistry of antifolates

  • M. G. Nair
Chapter

Abstract

Cancer can be defined as a disease that is characterised by a failure of the control mechanisms that are involved in cell division. Rapidly proliferating cells have a higher demand for DNA, and consequently require large quantities of purine and pyrimidine nucleotide substrates. Folic acid (1) plays a central role in the de novo biosynthesis of DNA. The coenzyme N5,N10-methylenetetrahydrofolate provides the one carbon unit necessary for the conversion of deoxyuridine monophosphate (dUMP) to thymidylic acid (dTMP).

Keywords

Dihydrofolate Reductase Antitumour Activity Raney Nickel Purine Biosynthesis ANTITUMOUR Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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