The chemistry of azolotetrazinones

  • M. D. Threadgill
Chapter

Abstract

In 1978, it was believed1,2that the 1,2,3,5-tetrazine ring was inherently unstable, despite claims3 of the preparation of this system.Indeed, there is only one confident report4of a [2,5-dihydro]-l,2,3,5-tetrazine without fusion to an azole. In 1979, Ege5published the first report of pyrazolo[5,1-d]-l,2,3,5-tetrazin-4(3H)-ones. There followed comprehensive reports6–8 by the Aston group of the synthesis and antitumour activity of 3-alkyl and 3-aryl-8-substitutedimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-ones and an indazolotetrazinone.

Keywords

ANTITUMOUR Agent Nitrogen Nucleophile Boiling Methanol P388 Murine Leukaemia Anchimeric Assistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Blackie & Son Ltd 1990

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  • M. D. Threadgill

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