New concepts of pathogenesis in IBD

  • C. Fiocchi

Abstract

Inflammatory bowel disease (IBD) still remains an enigma and there is no real understanding of its etiology and pathogenesis. In spite of this, efforts directed at uncovering predisposing factors, identifying specific etiologic agents, creating new animal models, investigating immunologic abnormalities, and developing novel and more effective forms of therapy continue to expand. Until the cause and mechanism(s) of IBD are clearly understood there remain many implicated factors, as demonstrated by the variety of topics presented in the chapters of this book. To a large extent this reflects limitations in knowledge, even though there is general agreement that both Crohn’s disease (CD) and ulcerative colitis (UC) are intricate multifactorial entities. In the face of this discouraging complexity an in-depth discussion of IBD pathogenesis can be quite extensive and diffuse. This laborious approach has already been taken, and comprehensive reviews are available1,2. This chapter will instead focus on selected and recent developments, particularly those having an impact on the pathophysiology of IBD.

Keywords

Inflammatory Bowel Disease Ulcerative Colitis Intestinal Permeability Ulcerative Colitis Patient Chronic Intestinal Inflammation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Kluwer Academic Publishers and Axcan Pharma, Inc. 1994

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  • C. Fiocchi

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