Oxidative Stress and Cell Damage Following Orthotopic Liver Transplantation.
Hepatic reperfusion injury in human orthotopic liver transplantation is associated with increased steady state levels of reactive oxygen species. Different hematic parameters of tissue redox balance can be analyzed in adult patients at the beginning of liver transplantation and at different times after reperfusion. A significant increase of oxidative stress parameters, i.e. red cell malonaldehyde and plasma lipoperoxides, is evident soon after reperfusion with respect to basal time and is accompanied by a decrease of plasma vitamin E. This alteration of redox balance is paralelled by a significant increase of cytolysis evaluated in terms of alanine aminotransferase. The presence of a significant correlation between alterations of the redox status and irreversible cell damage after liver reperfusion supports the implication of oxidative reactions in the occurence of ischemia- reperfusion tissue injury following orthotopic liver transplantation.
KeywordsLiver Transplantation Primary Biliary Cirrhosis Orthotopic Liver Transplantation Oxidative Stress Parameter Plasma Lipid Peroxide
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