Blood flow measurements using 3D distance-concentration functions derived from digital x-ray angiograms

  • Alexander M. Seifalian
  • David J. Hawkes
  • Christopher Bladin
  • Alan C. Colchester
  • Kenneth E. Hobbs
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 186)

Summary

We describe a method for measurement of velocity flow, absolute cross-sectional area and path length of identified arteries for high frame rate biplane x-ray angiograms. The system has been extensively validated with phantoms for vessel calibres from 3 to 6 mm and flow rates encompassing those expected “in-vivo”. Mean volume flow agreed with electromagnetic flow meter readings to within 9% and peak flow agreed to within 10% for velocity flow below 1 m/sec when measuring a 150 mm length of artery at a framing rate of 25 frames per sec. Path lengths of bent wire were measured with an error of less than 2%. We present initial results using these measures to study the haemodynamics of the circulation from the arch of the aorta to the circle of Willis.

Keywords

Digital Subtraction Angiography Vessel Segment Blood Flow Measurement Flow Waveform Epipolar Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Seifalian A.M, Stansby GP, Hobbs KE, Hawkes DJ, Colchester AC. Measurement of liver blood flow: a review. HPB Surg 1991;4:171–86.PubMedCrossRefGoogle Scholar
  2. 2.
    Seifalian AM. The computation of blood flow waveforms from digital x–ray angiographic data [Ph.D. Thesis]. London University, 1993.Google Scholar
  3. 3.
    Posner JB. Newer techniques of cerebral blood flow measurement. Stroke 1972;3:227–37.PubMedCrossRefGoogle Scholar
  4. 4.
    Jennett WB, Harper AM, Gillespie FC. Measurement of regional cerebral blood flow during carotid ligation. Lancet 1966;2:1162–3.PubMedGoogle Scholar
  5. 5.
    Harper AM. Measurement of cerebral blood flow by radioisotopes and its value in clinical practice. Practitioner 1971;207:291–300.PubMedGoogle Scholar
  6. 6.
    Pond GD, Osborne RW, Capp MP et al. Digital subtraction angiography of peripheral vascular bypass procedures. AJR Am J Roentgenol 1982; 138:279–81.PubMedGoogle Scholar
  7. 7.
    Guthaner DF, Wexler L, Enzmann DR et al. Evaluation of peripheral vascular disease using digital subtraction angiography. Radiology 1983;147:393–8.PubMedGoogle Scholar
  8. 8.
    Turnipseed WD, Sackett JF, Strother CM, Crummy A, Mistretta CA, Kruger RA. Computerized arteriography of the cerebrovascular system: its use with intravenous administration of contrast material. Arch Surg 1981;116:470–3.PubMedGoogle Scholar
  9. 9.
    Reiber JHC, Serruys PW editors. State of the art in quantitative coronary angiography. Dordrecht: Martinus Nijhoff, 1986.Google Scholar
  10. 10.
    Reiber JHC, Kooijman CJ, Slager CJ. Computer assisted analysis of the severity of obstructions from coronary cineangiograms: a methodological review. Automedica 1984;5:219–38.Google Scholar
  11. 11.
    Seifalian AM, Hawkes DJ, Colchester ACF, Hobbs KEF. A new algorithm for deriving pulsatile blood flow waveforms tested using stimulated dynamic angiographic data. Neuroradiology 1989;31:263–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Seifalian AM, Hawkes DJ, Hardingham CR, Colchester ACF, Reidy JF. Validation of a quantitative radiographic technique to estimate pulsatile blood flow waveforms using digital subtraction angiographic data. J Biomed Eng 1991;13:225–33.PubMedCrossRefGoogle Scholar
  13. 13.
    Mackay SA, Potel MJ, Rubin JM. Graphics methods for tracking three-dimensional heart wall motion. Comput Biomed Res 1982;15:455–73.PubMedCrossRefGoogle Scholar
  14. 14.
    Reiber JHC, Gerbrands JJ, Troost GJ et al. 3-D reconstruction of coronary arterial segments from two projections. In: Heintzen PH, Brennecke R, editors. Digital imaging in cardiovascular radiology. Stuttgart: Thieme, 1983:151–63.Google Scholar
  15. 15.
    Hawkes DJ, Colchester ACF, Mol CR. The accurate 3-D reconstruction of the geometric configuration of vascular trees from x-ray recordings In: Guzzardi R. editor. Physics and engineering of medical imaging. Dordrecht: Martinus Nijhoff, 1987:250–8.Google Scholar
  16. 16.
    Colchester ACF, Hawkes DJ, Brunt JNH, du Boulay GH, Wallis A. Pulsatile blood flow measurements with the aid of 3-d reconstruction from dynamic angiographic recordings. In: Bacharach SL, editor. Information processing in medical imaging. Dordrecht: Martinus Nijhoff, 1986:247–65.Google Scholar
  17. 17.
    Kim HC, Min BG, Lee TS, Lee SJ, Park JH, Han MC. Three-dimensional digital subtraction angiography. IEEE Trans Med Imaging 1982;MI–1:152–8.PubMedCrossRefGoogle Scholar
  18. 18.
    Rogers DF, Adams JA. Mathematical elements for computer graphics. 2nd ed. New York: McGraw-Hill, 1990:101–33.Google Scholar
  19. 19.
    Colchester ACF, Brunt JNH. Measurement of vessel calibre and volume blood flow by dynamic quatitative digital angiography: An initial application showing variation of cerebral artery diameter with PaCo2. J Cereb Blood Flow Metab 1983;3:S640–1.Google Scholar
  20. 20.
    Hawkes DJ, Colchester ACF, de Beider MA et al. The measurement of absolute lumen cross sectional area and lumen geometry in quantitative angiography. In: Todd–Pokropek AE, Viergever MA, editors. Medical images: formation, handling and evaluation. Heidelberg: Springer-Verlag, 1992:609–26.Google Scholar
  21. 21.
    Bland JM, Altman D. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;1:307–10.PubMedCrossRefGoogle Scholar
  22. 22.
    Hill DLG, Hawkes DJ, Crossman JE et al. Registration of MR and CT images for skull base surgery using point-like anatomical features. Br J Radiol 1991;64:1030–5.PubMedCrossRefGoogle Scholar
  23. 23.
    Hill DL, Hawkes DJ, Harrison N et al. A strategy for automated multimodality image registration incorporating anatomical knowledge and imager characteristics. Lecture Notes Comput Sci 1993;687:168–81.CrossRefGoogle Scholar
  24. 24.
    Robinson ML. Duplex sonography of the carotid arteries. Semin Roentgenol 1992;27:17–27.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Alexander M. Seifalian
  • David J. Hawkes
  • Christopher Bladin
  • Alan C. Colchester
  • Kenneth E. Hobbs

There are no affiliations available

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