Can Enzyme Mimics Compete with Catalytic Antibodies?
Many scientists are trying to create synthetic host molecules which mimic some of the recognition and catalytic properties of real enzymes. Enzymes catalyse chemical reactions with an efficiency that is awe-inspiring: they can bring together two unreactive substrate molecules, induce them to react, and then release the product at an astonishing speed. They are also subtle, usually forming just one of the many products that would result from a simple reaction carried out by a chemist. We know in general terms that enzymes achieve their catalysis by binding two substrate molecules in close proximity, by using binding energy and conformational changes to facilitate the approach to the transition state, and by using their own functional groups to intervene chemically, but we do not know all the rules. In particular we do not understand the balance between structural rigidity leading to pre-organised binding sites, and flexibility which allows the site to recognise and respond to the shape and size of the bound substrate.
KeywordsCholic Acid Catalytic Antibody Tetrahedral Intermediate Free Energy Profile Acyl Transfer Reaction
Unable to display preview. Download preview PDF.
- 3.Breslow, R (1991) Acc. Chem. Res., 24, 318–324.Google Scholar
- 5.Bonar-Law, R.P. and Davis, A. P. (1993) Tetrahedron, 49, 9829–9854; Bonar-Law, R.P. and Sanders, J. K. M. (1991) J. Chem. Soc. Chem. Commun., 574–577.Google Scholar
- 6. (a)
- 6. (b)
- 6. (c)
- 6. (d)
- 6. (e)
- 7.For reviews see the special issue of Accounts of Chemical Research, August 1993.Google Scholar
- 8. (a)
- 8. (b)
- 9.Flam, F. (1994) Science, 263, 1221–1222;Heilmann, J. and Maier, W. F. (1994) Angew. Chemie Intl. Edn.,33, 471–473.Google Scholar
- 11.Walter, C. J., Anderson, H. L., and Sanders, J. K. M. (1993) J. C. S., Chem. Commun., 458–460.Google Scholar
- 14.Mackay, L. G., Bonar-Law, R. P., and Sanders, J. K. M. (1992) J.C.S., Chem. Commun., 43–44.Google Scholar