Serum monoclonal immunoglobulins in renal transplant recipients: A study using high resolution electrophoresis and western blotting

  • Guy Touchard
  • Thierry Pasdeloup
  • Thierry Hauet
  • Marc Bauwens
  • Geneviève Dumont
  • Pierre Aucouturier
  • Jean-Louis Preud’Homme
Part of the Transplantation and Clinical Immunology book series (TRAC, volume 27)

Abstract

Transplant patients are prone to develop B cell lymphomas with a frequency increased by “high-dose” immunosuppressive regimens. Some studies suggest that transplant patients should be carefully screened to detect the occurrence of serum monoclonal immunoglobulins (moIg) which could be the first step of a patent immunoproliferative disorder.

Keywords

Chronic Lymphocytic Leukemia Renal Transplant Recipient Healthy Aged People Heavy Chain Constant Region Immunoglobulin Abnormality 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Radl J, Valentijn RM, Haaijman JJ and Paul LC. Monoclonal gammapathies in patients undergoing immunosuppressive treatment after renal transplantation. Clin Immunol Immunopathol 1985; 37: 98–102.PubMedCrossRefGoogle Scholar
  2. 2.
    Stanko CK, Jeffery JR and Rush DIN. Monoclonal and multiclonal gammapathies after renal transplantation. Transplant Proc 1989; 21: 3330–3332.PubMedGoogle Scholar
  3. 3.
    Pollock CA, Mahony JF, Ibels LS, Caterson RJ, Waugh DA, Wells JV and Ross Sheil AG. Immunoglobulin abnormalities in renal transplant recipients. Transplantation 1989; 47: 952–956.PubMedCrossRefGoogle Scholar
  4. 4.
    Chakalarovski C, Lang Ph, Buisson Cl, Weil B. Immunoglobulines monoclonales en transplantation rénale. Caractérisation, evolution et facteurs de risque. Presse Med 1991; 20: 2033–2035.PubMedGoogle Scholar
  5. 5.
    Modesto A, Rostaing L, Abbal M, Niquet L, Tkaczuk J, Durand D and Ohayon E. Long term follow-up of de novo monoclonal gammapathies. Transplant Proc 1994; 26: 282.PubMedGoogle Scholar
  6. 6.
    Radl J, Weis J and Hoogeven CM. Immunoblotting with (sub) class-specific antibodies reveals a high frequency of monoclonal gammapathies in persons thought to be immunodeficient. Clin Chem 1988; 34: 1839–1842.PubMedGoogle Scholar
  7. 7.
    Aucouturier P, Capella M, Briault S, Danon F, Intrator L, Preud’homme JL. Caractérisation des immunoglobulines monoclonales dans les liquides biologiques par immunoempreinte sur nitrocellulose. Rev Inst Pasteur Lyon 1987; 20: 147–153.Google Scholar
  8. 8.
    Connault L, Preud’homme JL, Gombert J, Aperce JM and Aucouturier P. Serum monoclonal immunoglobulins in healthy aged people: a study of incidence and isotype using a sensitive immuno-blotting method. Aging Immunol Infect Dis 1991; 3: 37–42.Google Scholar
  9. 9.
    Radl J, Weis J and Hoogeveen CM. Representation of IgG and IgA subclasses within monoclonal gammapathies of different origin. A minireview. In Poulik M.D Editor, Protides of the biological fluids, Oxford UK, Pergamon Press 1989; 143–146.Google Scholar
  10. 10.
    Radl J. Age-related monoclonal gammapathies: clinical lessons from aging C57 BL mouse. Immunol Today 1990; 11: 234–236.PubMedCrossRefGoogle Scholar
  11. 11.
    Beaume A, Brizard A, Dreyfus B and Preud’homme JL. High incidence of serum monoclonal Ig detected by a sensitive immunoblotting technique in B-cell chronic lymphocytic leukemia. Blood 1994; 84: 1216–9.PubMedGoogle Scholar
  12. 12.
    Aucouturier P and Preud’homme JL. Subclass distribution of human myeloma proteins as determined with monoclonal antibodies. Immunol Letters 1987; 16: 55–57.CrossRefGoogle Scholar
  13. 13.
    Walker S, Riches P and Hobbs JR. IgG subclasses of human monoclones differ between myeloma and post bone-marrow graft patients. In Poulik MD Editor. Protides of the biological fluids, Oxford UK Pergamon Press 1989; 36: 121–125.Google Scholar
  14. 14.
    Briault S, Courtois-Capella M, Duarte F, Aucouturier P and Preud’homme JL. Isotype of serum monoclonal immunoglobulins in human immunodeficiency virus-infected adults. Clin Exp Immunol 1988; 74: 182–184.PubMedGoogle Scholar
  15. 15.
    Hammarström L and Smith CIE. Frequent occurrence of monoclonal gammapathies with an imbalanced light-chain ratio following bone-marrow transplantation. Transplantation 1987; 43: 447–449.PubMedCrossRefGoogle Scholar
  16. 16.
    Riches P, Polce B and Hong R. Isotype analysis of specific antibody responses in long term survivors of bone-marrow transplantation. In Poulik MD Editor. Protides of the biological fluids, Oxford UK, Pergamon Press 1989; 36: 167–171.Google Scholar
  17. 17.
    Fischer AM, Simon F, Le Deist F, Blanche S, Griscelli C and Fischer A. Prospective study of the occurrence of monoclonal gammapathies following bone marrow transplantation in young children. Transplantation 1990; 49: 731–5.PubMedCrossRefGoogle Scholar
  18. 18.
    Mayumi M, Kuritani T, Kubagawa H and Cooper MO. IgG subclass expression by human B lymphocytes and plasma cells: B lymphocytes precommited to IgG subclass can be preferentially induced by polyclonal mitogens with T cell help. J Immunol 1983; 130: 611–611.Google Scholar
  19. 19.
    Touraine JL. Immunoglobulin abnormalities and infectious lymphoproliferative syndrome in cyclosporin treated transplant patients. Transplant Proc 1983; 15: 2798–2804.Google Scholar
  20. 20.
    Touraine JL, Deteix P, El Yafi M. Virus induced lymphomas in transplant patients under immunosuppressive therapy. Transplant Proc 1987; 19: 4087–4088.PubMedGoogle Scholar
  21. 21.
    Deteix P, Chapuis-Cellier C, Ghais Z, Lefrancois N, Brusa M, Touraine JL and Traeger J. Systematic survey of immunoglobulin abnormalities; frequency and evolution in organ transplant recipients. Transplant Proc 1985; 17: 2651–2654.Google Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Guy Touchard
  • Thierry Pasdeloup
  • Thierry Hauet
  • Marc Bauwens
  • Geneviève Dumont
  • Pierre Aucouturier
  • Jean-Louis Preud’Homme

There are no affiliations available

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