The St Thomas’ Atherosclerosis Regression Study and an appraisal of its potential limitations
The principal findings and potential limitations of the St Thomas’ Atherosclerosis Regression Study (STARS) are presented. STARS was a randomized endpoint blinded study of the effects of lipid-lowering therapy on angiographic coronary artery disease (CAD) in male patients with hypercholesterolemia. Both a fat-modified diet and diet-plus cholestyramine favourably influenced the course of CAD over 3 years. As discussed in this paper, the study did, however, have some limitations in respect of its sample size, use of angiography and generalizability of the findings.
KeywordsCoronary Atherosclerosis Quantitative Coronary Angiography Coronary Segment Percentage Diameter Stenosis Angiographic Coronary Artery Disease
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- 4.Watts GF, Lewis B, Brunt JNH, et al. Effects on coronary artery disease of lipid-lowering diet, or diet plus cholestyramine, in the St Thomas’ Atherosclerosis Regression Study (STARS). Lancet. 1992;339:536–69.Google Scholar
- 7.Watts GF. Lipid-lowering therapy and regression of atherosclerosis. Endocrinol Metab. 1994;1:71–87.Google Scholar
- 14.Pocock SJ. Clinical trials: a practical approach. Chichester: John Wiley & Sons; 1983.Google Scholar
- 16.Azen S, Blankenhorn DH, Nessim S. Planning and evaluation of studies on atherosclerosis in controlled clinical trials. In: Malinow MR, Blaton VH, editors. Regression of atherosclerotic lesions: experimental studies and observations in humans. New York: Plenum; 1984:263–75.Google Scholar
- 29.Watts GF, Mandalia S, Brunt JNH, et al. Metabolic determinants of the course of coronary artery disease in men. Clin Chem. 1995;40:2240–6.Google Scholar
- 30.Lewis B, Hammett F, Katan MB, et al. Towards an improved lipid-lowering diet: additive effects of changes in nutrient intake. Lancet. 1982;2:1310–13.Google Scholar
- 31.Mulcahy D, Kehely A, Fox K, et al. Risk reduction in patients with coronary artery disease: lipids and lost opportunities. Br J Cardiol. 1994;1:161–5.Google Scholar
- 32.Cohen MV, Byrne MJ, Levine B, et al. Low rate of treatment of hypercholesterolaemia by cardiologists in patients with suspected and proven coronary artery disease. Circulation. 1992;83:1294–304.Google Scholar