Ubiquitin and Ubiquitin-Like Conjugations in Complex Diseases: A Computational Perspective
As one class of most essential and common post-translational modifications (PTMs), ubiquitin and ubiquitin-like (Ub/UBL) conjugations play an important role in almost all aspects of biological processes, and aberrances in the conjugation systems are highly involved in numerous complex diseases. Identification of the Ub/UBL-associated enzymes, substrates and sites is fundamental for understanding the molecular mechanisms of Ub/UBL conjugations, and provides a potential reservoir for discovering disease biomarkers and drug targets. Besides experimental identifications, computational analysis of Ub/UBL conjugations has also emerged as an attractive field. In this chapter, we first summarized the cutting-edge experimental techniques in the large-scale identification of Ub/UBL conjugation substrates, and further emphasized the importance of computational efforts by introducing online databases and predictors for Ub/UBL conjugations. Although computational analysis of Ub/UBL conjugations is still immature, we believe more and more efforts will be paid in the near future.
KeywordsUbiquitin and ubiquitin-like conjugation Ubiquitination Sumoylation Proteomics Small cell lung cancer
This work was supported by grants from the National Basic Research Program (973 project) (2012CB910101, and 2013CB933903), Natural Science Foundation of China (31171263 and 81272578), and International Science and Technology Cooperation Program of China (0S2013ZR0003).
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