Adverse Intrauterine Environment and Gamete/Embryo-Fetal Origins of Diseases

  • Min-Yue Dong
  • Fang-Fang Wang
  • Jie-Xue Pan
  • He-Feng Huang
Chapter

Abstract

The ‘fetal origins of adult disease (FOAD)’ hypothesis proposes that developmental programming during gestation may influence adult health and disease [1]. It suggests a process where events occurring at critical, or sensitive, periods of fetal development, permanently alter structure, physiology, or metabolism. These changes predispose affected individuals to diseases in later life.

Barker and his colleagues were the first to develop the concept of FOAD based on significant associations between low birthweight and the risk of chronic diseases in adulthood, including coronary artery disease, hypertension and stroke, type 2 diabetes, and osteoporosis. Several other groups confirmed associations between birthweight and adult health in other populations. These adverse intrauterine environments include gestational diabetes mellitus (GDM), intrauterine undernutrition and pre-eclampsia, which are common and severe gestational complications. Furthermore, certain antenatal nutritional disturbances can increase the risk of diseases later in life without affecting fetal growth. In this chapter, we will discuss the evidence related to adverse intrauterine environment and embryo-fetal origins of diseases.

Keywords

Gestational Diabetes Mellitus Severe Preeclampsia Antiangiogenic Factor Maternal Undernutrition Preeclamptic Pregnancy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Min-Yue Dong
    • 1
    • 2
  • Fang-Fang Wang
    • 1
    • 2
  • Jie-Xue Pan
    • 1
    • 2
  • He-Feng Huang
    • 1
    • 2
  1. 1.The Key Laboratory of Reproductive GeneticsZhejiang University, Ministry of EducationHangzhouPeople’s Republic of China
  2. 2.Department of Reproductive EndocrinologyWomen’s Hospital, School of Medicine, Zhejiang UniversityHangzhouPeople’s Republic of China

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