Cobalt: Its Role in Health and Disease

Part of the Metal Ions in Life Sciences book series (MILS, volume 13)

Abstract

The primarily function of cobalt in humans is based on its role in cobalamin (Cbl, vitamin B12). Therefore, this chapter will focus on the physiological roles of Cbl and the importance of cobalt in human health. Cbl acts as the cofactor for two enzymes, i.e., methylmalonyl-CoA mutase and methionine synthase, in humans. Both enzymes are important for health. In addition, unlike other water-soluble vitamins, there is a unique absorption, delivery, and activation system for Cbl in mammals. Therefore, this chapter will also review the literature on the Cbl transporting system, which is crucial for Cbl function.

Keywords

cobalamin methionine synthase methylmalonyl-CoA mutase vitamin B12 

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of BiochemistryUniformed Services University of the Health SciencesBethesdaUSA

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