Synthesis and Characterization of 6-Carbamoyl-2-Alkyl-9-(Phenyl or Benzyl)-9H-Purines

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Abstract

The 2-(5-amino-1-phenyl or benzyl)-4-(cyanoformimidoyl)-1H-imidazoles proved to be important intermediates not only in the preparation of new 6-carbamoyl purines but also in the synthesis of 6-amino-purine, 6-cyano-purine and 1,2-dihydropurines. 6-Carbamoyl-2-alkyl-9-(phenyl or benzyl)-9H-purines have been synthesized in high yields by reactions between 2-(5-amino-1-phenyl or benzyl)-4-(cyanoformimidoyl)-1H-imidazoles and acetylacetone at room temperature. Intramolecular hydrogen bonding appears between H of NH2 and N1 at purine ring. All the compounds have been fully characterized by spectroscopic data.

Keywords

Intramolecular Hydrogen Bonding Imidazole Ring Broad Singlet High Resolution Mass Spectrum Elemental Analysis Result 
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Notes

Acknowledgements

We are thankful to the Guilan University Research Council for partial support of this work.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of GuilanRashtIran

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