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Molecular Diagnostics of Pancreatic Cancer

  • Edward J. Richards
  • William Kong
  • Mokenge Malafa
  • Jin Q. Cheng
  • Domenico Coppola
Chapter
Part of the Cancer Growth and Progression book series (CAGP, volume 16)

Abstract

Pancreatic cancer is a malignant disease relating to uncontrollable cell growth in the tissues of the pancreas. The vast majority of pancreatic cancers are ductal adenocarcinomas, originating in the epithelial layer of the exocrine pancreas, however some pancreatic cancers do originate in the endocrine compartment. Ductal adenocarcinomas are very aggressive cancers, associating with poor prognosis and late staging upon discovery. One reason for this is that many patients do not present symptoms until late onset of disease. Numerous research efforts have been put forth to earlier diagnose pancreatic cancer. Understanding of pancreatic cancer etiology and identification of associated tumor markers has progressed, however there is a clear need for more specific and sensitive technologies. This chapter aims to address current status of molecular diagnostics in pancreatic cancer.

Keywords

Pancreatic cancer Molecular diagnostics Tumor markers KRAS Micro RNA 

Abbreviations

CA-19-19

Carbohydrate antigen 19 9

CA-242

Carbohydrate antigen 242

CEA

Carcinoembryonic antigen

CK7/17/20

Cytokeratin 7/17/20

CTCs

Circulating tumor cells

GWAS

Genome wide association study

IPMNs

Intraductal papillary mucinous neoplasms

MCNs

Mucinous cystic neoplasms

MIC-1

Macrophage inhibitory cytokine 1

miRNA

MicroRNA

MSLN

Mesothelin

mtDNA

mitochondrial DNA

MUC4

Mucin 4

OPN

Osteopontin

PanINs

Pancreatic intraepithelial neoplasias

PDAC

Pancreatic ductal adenocarcinoma

SELDI

Surface enhanced laser desorption and ionization

SNP

Single nucleotide polymorphism

TPS

Tissue polypeptide specific antigen

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Edward J. Richards
    • 1
  • William Kong
    • 1
  • Mokenge Malafa
    • 2
    • 3
  • Jin Q. Cheng
    • 1
  • Domenico Coppola
    • 3
    • 4
    • 5
  1. 1.Department of Molecular OncologyH. Lee Moffitt Cancer Center and Research InstituteTampaUSA
  2. 2.Department of Surgical OncologyH. Lee Moffitt Cancer Center and Research InstituteTampaUSA
  3. 3.Department of Oncological SciencesUniversity of South Florida College of MedicineTampaUSA
  4. 4.Department of Anatomic PathologyH. Lee Moffitt Cancer Center and Research InstituteTampaUSA
  5. 5.Department of Pathology and Cell BiologyH. Lee Moffitt Cancer CenterTampaUSA

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