Endoplasmic Reticulum Stress-Associated gp96 Chaperone is a Host Receptor for Adherent-Invasive E. coli

Chapter
First Online:
Part of the Heat Shock Proteins book series (HESP, volume 7)

Abstract

Crohn’s disease (CD) is a chronic intestinal disease in humans that develop due to an abnormal inflammatory response to the intestinal microbiota in genetically susceptible hosts. Ileal lesions of CD patients are abnormally colonized by Adherent-Invasive Escherichia coli (AIEC) producing outer membrane vesicles (OMVs) that contribute to the bacterial invasion process. Endoplasmic reticulum (ER) stress is observed at the intestinal mucosa in CD patients with increased expression of ER-localised stress response proteins. In particular in patients with ileal CD, the ER-stress response chaperone Gp96 is strongly expressed on the apical surface of ileal epithelial cells and acts as a host cell receptor for OMVs. As a consequence, this chaperone contributes to increased bacterial invasion of host cells by AIEC.

Keywords

Endoplasmic Reticulum Stress Endoplasmic Reticulum Lumen Human Brain Microvascular Endothelial Cell Outer Membrane Vesicle Gp96 Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Nathalie Rolhion
    • 1
  • Arlette Darfeuille-Michaud
    • 2
    • 3
    • 4
    • 5
  1. 1.Section of Microbiology, MRC Center for Molecular Bacteriology and InfectionImperial College LondonLondonUK
  2. 2.Clermont Université, Université d’AuvergneClermont-FerrandFrance
  3. 3.Inserm U1071, Centre Biomédical de Recherche et ValorisationUniversité d’AuvergneClermont-FerrandFrance
  4. 4.INRA, USC2018Clermont-FerrandFrance
  5. 5.Centre Hospitalo-UniversitaireClermont-FerrandFrance

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