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Instability Process Across Generations. Consequences of Nuclear Test Fallout for Inhabitants

  • Victoria L. Korogodina
  • Boris V. Florko
  • Ludmila P. Osipova
Chapter

Abstract

The radiation effects on the human populations living in regions distant from the sites of nuclear explosions that took place in the middle of the previous century are analyzed. The statistical modelling was performed to study the occurrence frequency of abnormal lymphocyte cells among the proliferated ones in the blood of individuals living in the Yamalo-Nenets autonomous district (North Siberia), and settlements in Maloe Goloustnoe and Listvyanka (Pribaikal’e). Four generations of individuals were tested. It was shown that the geometric model component corresponds to the individuals with bad activated lymphocyte cells, lymphocyte pool depletion, and increased mortality, and the Poisson model means accumulation of abnormal cells. The Poisson component was only revealed in younger generations and can be interpreted as “effect of youth.” The worst situation is observed in the Northern population, which can be expected due to Northern permafrost and the traditional food chain of “lichen-reindeer-man”. The influence of the radiochemical industry on the occurrence of multi-aberrant cells in the blood of its workers and the inhabitants of the town in which it operates was studied by the statistical modelling, with elevated chromosomal instability being found. We conclude that chromosomal instability induced by nuclear test fallout continued for four generations. It was shown that the Poisson sample mean decreased very slowly across a generation which disputes the opinion that reduction of cellular instability in youngsters in the previous investigations was based on the averaged values. In addition, aging and extreme conditions increase the risks of chromosomal instability and mortality.

Keywords

Nuclear test fallout Northern extreme conditions Statistical modelling Aging Chromosomal abnormalities Transgenerational instability Risks of chromosomal instability Radiochemical industry 

References

  1. Abil’dinova GZ, Kuleshov NP, Sviatova GS (2003) Chromosomal instability parameters in the population affected by nuclear explosions at the Semipalatinsk nuclear test site. Genetika 39:1123–1127 (Russian)Google Scholar
  2. Antonova E, Osipova LP, Florko BV et al (2008a) The comparison of distributions of individuals with normally and poorly stimulated blood cell activity on the frequency of aberrant cells’ occurrence in blood lymphocytes. Rep Russ Mil-Med Acad 1(3):73 (Russian)Google Scholar
  3. Antonova E, Osipova LP, Sen’kova NA et al (2008b) The comparison of distributions of individuals under 18 and older on the frequency of aberrant cells’ occurrence in blood lymphocytes in the samples of individuals living in the settlements of Maloe Goloustnoe and Listvyanka in Irkutsk region. Rep Russ Mil-Med Acad 1(3):90 (Russian)Google Scholar
  4. Averbeck D (2010) Non-targeted effects as a paradigm breaking evidence. Mutat Res 687:7–12CrossRefGoogle Scholar
  5. Bezdrobna L, Tsyaganok T, Romanova O et al (2002) Chromosomal aberrations in blood lymphocytes of the residents of 30-km Chernobyl NPP exclusion zone. In: Imanaka T (ed) Recent research activities about the Chernobyl NPP accident in Belarus, Ukraine and Russia. Kyoto Universtiy Research Reactor Institute (KURRI-KR-79), pp 277–287Google Scholar
  6. Bochkov NP, Yakovenko KN, Chebotarev AN et al (1972) Distribution of the damaged chromosomes on human cells under chemical mutagens effects in vitro and in vivo. Genetika 8:160–167 (Russian)Google Scholar
  7. Bochkov NP, Chebotarev AN, Katosova LD et al (2001) The database for analysis of quantitative characteristics of chromosome aberration frequencies in the culture of human peripheral blood lymphocytes. Genetika 37:549–557 (Russian)Google Scholar
  8. Bochkov NP (1993) Analytic review of the cytogenetic investigations after the Chernobyl accident. Bull Russ Acad Med Sci 6:51–56 (Russian)Google Scholar
  9. Bolegenova NK, Bekmanov BO, Djansugurova LB et al (2009) Genetic polymorphisms and expression of minisatellite mutations in a 3-generation population around the Semipalatinsk nuclear explosion test-site, Kazakhstan. Int J Hyg Environ Health 212:654–660CrossRefGoogle Scholar
  10. Boltneva LI, Izrael YA, Ivanov VA et al (1977) Global 137Cs and 90Sr pollution and doses of the external radiation exposure in the USSR territory. Atomnaya Energiya 42:355–360 (Russian)CrossRefGoogle Scholar
  11. Cao S, Deng Z, Zhen Z et al (1981) Lymphocyte chromosome aberrations in personnel occupationally exposed to low levels of radiation. Health Phys 41:586Google Scholar
  12. Chebotarev AN (2000) A mathematical model of origin of multi-aberrant cell during spontaneous mutagenesis. Rep RAS 371:207–209 (Russian)Google Scholar
  13. Daillant O, Boilley D, Gerzabek M et al (2004) Metabolised tritium and radiocarbon in lichens and their use as biomonitors. J Atmospheric Chem 49:329–341CrossRefGoogle Scholar
  14. Davis W Jr, Ronai Z, Tew KD (2001) Cellular thiols and reactive oxygen species in drug-induced apoptosis. J Pharmacol Exp Theor 296:1–6Google Scholar
  15. Dubrova YE, Jeffreys A, Nesterov VN et al (1996) Human minisatellite mutation rate after the Chernobyl accident. Nature 380:683–686CrossRefGoogle Scholar
  16. Dubrova YE (2003) Radiation-induced transgenerational instability. Oncogene 22:7087–7093CrossRefGoogle Scholar
  17. Eliseeva IM, Iofa EL, Stoian EF et al (1994) An analysis of chromosome aberrations and SCE in children from radiation-contaminated regions of Ukraine. Radiats Biol Radioecol 34:163–171 (Russian)Google Scholar
  18. Feller W (1957) An introduction to probability theory and its applications. Wiley/Chapman & Hall, Limited, New York/LondonGoogle Scholar
  19. Florko BV, Korogodina VL (2007) Analysis of the distribution structure as exemplified by one cytogenetic problem. PEPAN Lett 4:331–338Google Scholar
  20. Florko BV, Osipova LP, Korogodina VL (2009) On some features of forming and analysis of distributions of individuals on the number and frequency of aberrant cells among blood lymphocytes. Math Biol Bioinform 4:52–65Google Scholar
  21. Korogodin VI, Bliznik М (1972) Formation of radioraces by yeasts. Comm. 1. Radioraces of diploid yeasts Saccaromyces ellipsoideus vini. Radiologiya 12:163–170 (Russian)Google Scholar
  22. Korogodin VI, Bliznik KM, Kapultsevich YG (1977) Regularities of radioraces formation in yeasts. Comm. 11. Facts and hypotheses. Radiologiya 17:492–499 (Russian)Google Scholar
  23. Korogodina VL, Florko BV, Osipova LP et al (2010a) The adaptation processes and risks of chromosomal instability in populations. Biosphere 2:178–185 (Russian)Google Scholar
  24. Korogodina VL, Florko BV, Osipova LP (2010b) Adaptation and radiation-induced chromosomal instability studied by statistical modeling. Open Evol J 4:12–22CrossRefGoogle Scholar
  25. Lazjuk G, Satow Y, Nikolaev D et al. (1999) Genetic consequences of the Chernobyl accident for Belarus Republic. In: Imanaka T (ed) Recent research activities about the Chernobyl NPP accident in Belarus, Ukraine and Russia. Kyoto University Research Reactor Institute (KURRI-KR-7), pp 174–177Google Scholar
  26. Liden K (1961) 137Cs burdens in Swedish Laplanders and reindeer. Аcta Radiol 56:64–65Google Scholar
  27. Matveeva VG, Sablina OV, Eremina VR et al (1993) Cytogenetics of the inherent pathology in the inhabitants of the Altai radiation-polluted zones. In: Genetic effects of the anthropogenic environment factors. Novosibirsk 1: 5–7 (Russian)Google Scholar
  28. Medvedev VI, Korshunov LG, Chernyago BP (2005) Radiation effect of Semipalatinsk nuclear polygon on the South Siberia (investigations of several years on the East and Middle Siberia and the comparison with the data on the West Siberia). Siberia Ecol J XII:1055–1071 (Russian)Google Scholar
  29. Medvedev VI, Korshunov LG, Chernyago BP et al (2009) Radiation effect of the Semipalatinsk nuclear polygon on the South Siberia. Probl Biogeochem Geochem Ecol 2:57–65 (Russian)Google Scholar
  30. Mikhalevich LS (1999) Monitoring of cytogenetic damages in peripheral lymphocytes of children living in radiocontaminated areas of Belarus In: Imanaka T (ed) Recent research activities about the Chernobyl NPP accident in Belarus, Ukraine and Russia. Kyoto University Research Reactor Institute (KURRI-KR-79), pp 178–188Google Scholar
  31. Moorhead PS, Howell PC, Mellman WJ (1960) Chromosome preparations of leucocytes cultured from human peripheral blood. Exp Cell Res 20:613–616CrossRefGoogle Scholar
  32. Nepomnyaschih AI, Chernyago BP, Medvedev VI et al (1999) Radioecological condition of the Irkutsk region territory. Joint report on the program “Radon” (1998) of the Institute of geochemistry SB RAS, Irkutsk State University, St. Petersburg Institute of Radiation Hygiene, Irkutsk, pp 48–49Google Scholar
  33. Nizhnikov AI, Nevstrueva MA, Ramzaev PV et al (1969) Cs137 in food chain lichen-reindeer –man in Far North USSR (1962–1968). Atomizdat, MoscowGoogle Scholar
  34. Osipova LP, Posukh OL, Koutzenogii KP et al (1999) Epidemiological studies for the assessment of risks from environmental radiation on Tundra Nenets population. In: Baum Stark-Khan C et al (eds) NATO science series (2): environmental security, vol 55. Kluwer, Dordrecht, pp 35–42Google Scholar
  35. Osipova LP, Posukh OL, Ponomareva AV et al (2000a) Medicogenetics investigations of the population of Tundra Nenets and evaluation of radiation situation in the region of their habitation. Siberian Ecologycal J 1:61–65 (Russian)Google Scholar
  36. Osipova LP, Ponomareva AV, Shcherbov BL et al (2000b) Aftermath of radiation effect in population of Tundra Nenets inhabitants, Purov region, YaNAD. In: Proceedings of the international conference on “Modern Problems of Radiobiology, Radioecology and Evolution”. JINR, Dubna, 2000, pp 200–212 (Russian)Google Scholar
  37. Osipova LP, Koutsenogii KP, Shcherbov BL et al (2002) Environmental radioactivity for risk assessment of health status in nature and human population of Northern Siberia. In: Proceedings of the 5th international conference on environmental radioactivity in the Arctic and Antarctic. St. Petersburg, 2002, pp 124–127 (Russian)Google Scholar
  38. Osipova LP, Sen’kova NA, Gainer TA et al (2008) Cytogenetic assessment of the late consequences of the radiation factors on the inhabitants of the settlement Maloe Goloustnoe in the Irkutsk region. Rep Russ Mil-Med Acad 1(3):134 (Russian)Google Scholar
  39. Pilinskaya MA, Shemetun AM, Eremeeva MN et al (1991) The cytogenetic effect in the peripheral blood lymphocytes of persons with a history of acute radiation sickness as a result of the accident at the Chernobyl Atomic Electric Power Station. Tsitol Genet 25(4):17–21 (Russian)Google Scholar
  40. Pinzino C, Capocchi A, Galleschi L et al (1999) Aging, free radicals, and antioxidants in wheat seeds. J Agric Food Chem 47:1333–1339CrossRefGoogle Scholar
  41. Scherbov BL, Malikova IN, Osipova LP et al (2006) Radioecology conditions in the territories of the Siberia native inhabitants at the turn of the XX-XXI centuries. Probl Biogeochem Geochem Ecol 3(3):520–531 (Russian)Google Scholar
  42. Seabright MA (1971) Rapid banding technique for human chromosomes. Lancet 2:971–972CrossRefGoogle Scholar
  43. Sevan’kaev AV, Potetnia OI, Zhloba AA et al (1995) The results of the cytogenetic examination of children and adolescents living in radionuclide-contaminated regions of Kaluga province. Radiats Biol Radioecol 35:581–588 (Russian)Google Scholar
  44. Shevchenko VA, Snigireva GP, Suskov II et al (1995) The cytogenetic effects in the population of the Altai territory subjected to ionizing radiation exposure as a result of the nuclear explosions at the Semipalatinsk proving grounds. Radiats Biol Radioecol 35(5):588–596 (Russian)Google Scholar
  45. Shevchenko VA (1997) Integral estimation of genetic effects of ionizing radiation. Radiats Biol Radioecol 37(4):569–576 (Russian)Google Scholar
  46. Shevchenko VA, Snigiryova GP (1999) Cytogenetic effects of the action of ionizing radiations on human populations. In: Imanaka T (ed) Recent research activities about the Chernobyl NPP accident in Belarus, Ukraine and Russia. Kyoto University Research Reactor Institute (KURRI-KR-79), pp 203–216Google Scholar
  47. Tanaka K, Iida S, Takeichi N et al (2006) Unstable-type chromosome aberrations in lymphocytes from individuals living near Semipalatinsk nuclear test site. J Radiat Res (Tokyo) 47(Suppl A):A159–A164CrossRefGoogle Scholar
  48. The Ministry of Nature of RF (1992) Criteria for the assessment of ecological conditions in the territories to test zone in extreme ecological situation. The Ministry of Nature of RF, MoscowGoogle Scholar
  49. Vorobtsova IE, Vorob’eva MV, Bogomazova AN et al (1995) The cytogenetic examination of children in the Saint Petersburg region who suffered as a result of the accident at the Chernobyl Atomic Electric Power Station. The frequency of unstable chromosome aberrations in the peripheral blood lymphocytes. Radiats Biol Radioecol 35(5):630–635 (Russian)Google Scholar
  50. Yablokov AV, Nesterenko VB, Nesterenko AV (2009) Chernobyl: consequences of the catastrophe for people and the environment. Ann N Y Acad Sci 1181:vii–xiii, 1–327CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Victoria L. Korogodina
    • 1
  • Boris V. Florko
    • 1
  • Ludmila P. Osipova
    • 2
  1. 1.Joint Institute for Nuclear ResearchMoscowRussia
  2. 2.Institute of Cytology and Genetics SB RASNovosibirskRussia

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