Instability Process Across Generations. Consequences of Nuclear Test Fallout for Inhabitants

  • Victoria L. Korogodina
  • Boris V. Florko
  • Ludmila P. Osipova


The radiation effects on the human populations living in regions distant from the sites of nuclear explosions that took place in the middle of the previous century are analyzed. The statistical modelling was performed to study the occurrence frequency of abnormal lymphocyte cells among the proliferated ones in the blood of individuals living in the Yamalo-Nenets autonomous district (North Siberia), and settlements in Maloe Goloustnoe and Listvyanka (Pribaikal’e). Four generations of individuals were tested. It was shown that the geometric model component corresponds to the individuals with bad activated lymphocyte cells, lymphocyte pool depletion, and increased mortality, and the Poisson model means accumulation of abnormal cells. The Poisson component was only revealed in younger generations and can be interpreted as “effect of youth.” The worst situation is observed in the Northern population, which can be expected due to Northern permafrost and the traditional food chain of “lichen-reindeer-man”. The influence of the radiochemical industry on the occurrence of multi-aberrant cells in the blood of its workers and the inhabitants of the town in which it operates was studied by the statistical modelling, with elevated chromosomal instability being found. We conclude that chromosomal instability induced by nuclear test fallout continued for four generations. It was shown that the Poisson sample mean decreased very slowly across a generation which disputes the opinion that reduction of cellular instability in youngsters in the previous investigations was based on the averaged values. In addition, aging and extreme conditions increase the risks of chromosomal instability and mortality.


Nuclear test fallout Northern extreme conditions Statistical modelling Aging Chromosomal abnormalities Transgenerational instability Risks of chromosomal instability Radiochemical industry 


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Victoria L. Korogodina
    • 1
  • Boris V. Florko
    • 1
  • Ludmila P. Osipova
    • 2
  1. 1.Joint Institute for Nuclear ResearchMoscowRussia
  2. 2.Institute of Cytology and Genetics SB RASNovosibirskRussia

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