New Advances in Gastrointestinal Motility Research

  • Leo K. Cheng
  • Gianrico Farrugia
Part of the Lecture Notes in Computational Vision and Biomechanics book series (LNCVB, volume 10)


Gastrointestinal motility is an area of research that has gained renewed interest in recent years. However, it is evident that there still remains much to be learnt and discovered. The chapters in this volume entitled “New Advances in Gastrointestinal Motility Research” result from a meeting which took place at The University of Auckland, New Zealand in October/November 2011 and provide a summary of discussions. Both the meeting and this book were brainchilds of Professor Andrew Pullan. However, Professor Andrew Pullan tragically passed away between the inception and completion of this series. This book not simply dedicated to him and his family but is a reflection of his ideas and work. The 12 remaining chapters of this volume are arranged into 4 broad sections: covering gastrointestinal cellular activity and tissue structure; techniques for measuring, analyzing and visualizing high-resolution extra-cellular recordings; methods for modulating gastric electrical activity as well as sensing the resultant activity using non-invasive bio-electro-magnetic fields; and finally methods for assessing manometric and videographic motility patterns and the application of these data for predicting the flow and mixing behavior of luminal contents by using computational fluid dynamic techniques. As a result, this volume aims to provide both an overview of existing research techniques over a range of research areas as well as to highlight future directions and challenges for the community as a whole.


Gastrointestinal Motility Extracellular Recording Gastric Electrical Stimulation Electrical Regulation Gastric Electrical Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



LKC was supported in part by the New Zealand Health Research Council, and the NIH (R01 DK64775). GF was supported in part by grants from the NIH (R01 DK57061, P01 DK 68055-P1 and R01 DK 52766). The New Advances in Gastrointestinal Motility Research Meeting held in Auckland, New Zealand was made possible by a grant from The University of Auckland Faculty Development Research Fund. The authors would like to acknowledge the contributions of Professor Andrew Pullan who tragically passed away between the inception and completion of this series.


  1. 1.
    Alvarez WC, Mahoney LJ (1922) Action currents in stomach and intestine. Am J Physiol 58:476–493Google Scholar
  2. 2.
    Alvarez WC (1992) The electrogastrogram and what it shows. JAMA 78:1116–1119Google Scholar
  3. 3.
    Cajal RR (1911) Rev Clin, 5th edn. Madrid 1911, pp 206–209Google Scholar
  4. 4.
    Grover M, Farrugia G, Lurken MS, Bernard CE, Faussone-Pellegrini MS, Smyrk TC, Parkman HP, Abell TL, Snape WJ, Hasler WL, Unalp-Arida A, Nguyen L, Koch KL, Calles J, Lee L, Tonascia J, Hamilton FA, Pasricha PJ (2011) Consortium NGCR. Cellular changes in diabetic and idiopathic gastroparesis. Gastroenterology 140(5):1575–1585 e1578Google Scholar
  5. 5.
    He CL, Burgart L, Wang L, Pemberton J, Young-Fadok T, Szurszewski J, Farrugia G (2000) Decreased interstitial cell of cajal volume in patients with slow-transit constipation. Gastroenterology 118(1):14–21Google Scholar
  6. 6.
    Huizinga JD, Thuneberg L, Kluppel M, Malysz J, Mikkelsen HB, Bernstein A (1995) W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 373(6512):347–349PubMedCrossRefGoogle Scholar
  7. 7.
    Isozaki K, Hirota S, Miyagawa J, Taniguchi M, Shinomura Y, Matsuzawa Y (1997) Deficiency of c-kit + cells in patients with a myopathic form of chronic idiopathic intestinal pseudo-obstruction. Am J Gastroenterol 92(2):332–334PubMedGoogle Scholar
  8. 8.
    Miller SM, Narasimhan RA, Schmalz PF, Soffer EE, Walsh RM, Krishnamurthi V, Pasricha PJ, Szurszewski JH, Farrugia G (2008) Distribution of interstitial cells of Cajal and nitrergic neurons in normal and diabetic human appendix. Neurogastroenterol Motil 20(4):349–357PubMedCrossRefGoogle Scholar
  9. 9.
    Waller AD (1887) A demonstration on man of electromotive changes accompanying the heart’s beat. J Physiol (Lond) 8:229–234Google Scholar
  10. 10.
    Ward SM, Burns AJ, Torihashi S, Sanders KM (1994) Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J Physiol (Lond) 480(Pt 1):91–97Google Scholar
  11. 11.
    Wedel T, Spiegler J, Soellner S, Roblick UJ, Schiedeck TH, Bruch HP, Krammer HJ (2002) Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon. Gastroenterology 123(5):1459–1467PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Auckland Bioengineering InstituteThe University of AucklandAucklandNew Zealand
  2. 2.Department of SurgeryVanderbilt UniversityNashvilleUSA
  3. 3.Enteric Neuroscience Program, Division of Gastroenterology & HepatologyMayo ClinicRochesterUSA

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