Radioprotective Properties of Selenomethionine with Methionine, Extracts from Basidium Fungi and Exogenous DNA

  • Alexander D. Naumov
  • Natalia I. TimokhinaEmail author
  • Alexandra V. Litvinchuk
  • Gennadii G. Vereshchako
  • Alina M. Khodosovskaya
  • Svetlana N. Sushko
  • Elena M. Kadukova
Conference paper
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)


The search for effective substances to provide protection to the organism under radiation treatment continues to be one of the most important directions for studies in radiobiology. The results of the study show that selenmethionine in the indicated doses with methionine (4 mg/kg) have pronounced efficiency on the defense of organisms against acute irradiation at a dose of 2 Gy. This was shown in the recovery of leucocytes in the blood, the increase in the total number of spermatogenic cells, and a significant increase in the spermatid count by 2 months after irradiation (2.3–2.6 times). This may provide a restoration in the process of spermatogenesis as well as normalization of lipid peroxidation processes and transamination enzymes activities in the irradiated animals. We also studied the anti-tumoral and radioprotective activities of the mushroom aqueous extracts. The antitumoral properties of Flammulina velutipes are shown. Its aqueous extracts decrease a spontaneous level of adenomas and, as well as Auricularia auricular-judae, reduce the yield of urethane-induced adenomas. The aqueous extracts of Flammulina velutipes and Phallus impudicus demonstrate radioprotective properties, i.e. reduce a number of adenomas in irradiated mice, raise mice survival and stimulate a growth of endogenous colonies in spleen. We prepared and studied the exogenous DNA. Micronuclei tests of bone marrow show an improvement in the DNA repair process in erythroblasts of irradiated and treated animals. Based on PCR analysis, it was suggested that the exogenous DNA substance can protect cardiac cells from the activation of pro-apoptotic gene Bax, and it can rescue the heart from irradiation-induced apoptosis. Thus the studied substances can be promising agents for protection and recovery of an organism from radiation injury.


Aqueous Extract Spermatogenic Cell Irradiate Mouse Spleen Weight Radioprotective Effect 
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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Alexander D. Naumov
    • 1
  • Natalia I. Timokhina
    • 1
    Email author
  • Alexandra V. Litvinchuk
    • 1
  • Gennadii G. Vereshchako
    • 1
  • Alina M. Khodosovskaya
    • 1
  • Svetlana N. Sushko
    • 1
  • Elena M. Kadukova
    • 1
  1. 1.Institute of Radiobiology of the National Academy of Sciences of BelarusGomelBelarus

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