Role of Cancer Stem Cell in Mammary Carcinogenesis and Its Clinical Implication

Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 10)

Abstract

Accumulating evidence shows the presence of a subpopulation of cancer stem cells in many cancers including breast cancer. The breast cancer stem cells are resistant to treatments and able to initiate tumorigenesis, these features suggest that they may contribute to therapy resistance and relapse and thus making them a promising target for improving outcome of treatments. The expression of specific markers in breast cancer stem cells and development of mouse model has facilitated the study and several intrinsic and extrinsic pathways maintaining breast cancer stem cell population have been exploited. The discovery of different states of breast cancer stem cells provides more insights in how cancer stem cells are maintained and regulated. Compounds targeting pathways maintaining cancer stem cells are under development and several have already entered clinical trials. Breast cancer stem cell studies deliver a potential and effective regimen for improving outcomes of breast cancer patients.

Keywords

Cancer Stem Cell Side Population Breast Cancer Stem Cell Breast CSCs Cancer Stem Cell Population 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Comprehensive Cancer Center, Department of Internal MedicineUniversity of MichiganAnn ArborUSA
  2. 2.School of Life SciencesUniversity of Science and Technology of China443 Huangshan Rd, HefeiChina

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