Pituitary Tumorigenesis: Role of Regulation of Wee1 Kinase by microRNAs

Chapter
Part of the Tumors of the Central Nervous System book series (TCNS, volume 10)

Abstract

Mechanisms involved in pituitary tumorigenesis, especially of non-functional pituitary adenomas remain unclear. Various cell cycle inhibitors have been found to be underexpressed in pituitary tumors. However alterations of the G2/M checkpoint have not been revealed as a major player in the pathogenic process. Wee1 kinase, a nuclear protein that delays G2/M transition has been recently recognized as a tumor suppressor and has been found as a potential pathogenic factor in pituitary adenomagenesis. In this chapter after a brief summary of the cell cycle regulation, the biogenesis and function of miRs in pituitary adenomas, we review the role and function of Wee1 kinase focusing on its potential role in pituitary tumorigenesis. MicroRNAs posttranscriptionally regulating expression of Wee1 kinase and their expression and role in pituitary adenoma development are also discussed.

Keywords

Pituitary Adenoma Pituitary Tumor Overexpressed miRs Mitotic Catastrophe Mitotic Entry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Faculty of Medicine, Second Department of MedicineSemmelweis UniversityBudapestHungary
  2. 2.Molecular Medicine Research GroupHungarian Academy of SciencesBudapestHungary
  3. 3.Department of Laboratory MedicineSemmelweis UniversityBudapestHungary

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