Metallomics and the Cell pp 169-201

Part of the Metal Ions in Life Sciences book series (MILS, volume 12)

Manganese Homeostasis and Transport


The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson’s disease (PD) and sensitivity to Mn.


divalent metal transporter 1 (DMT1) manganese mitochondria parkin transport Please cite as: Met. Ions Life Sci. 12 (2013) 169–201 



Alzheimer’s disease




blood-brain barrier




C/EBP homologous protein


central nervous system






dopamine- and cAMP-regulated neuronal phosphoprotein


dopamine transporter


duodenal cytochrome B


divalent metal transporter 1


endoplasmic reticulum


estimated safe and adequate dietary intake




γ-aminobutyric acid


glucose-regulated protein 78




human embryonic kidney cells 293


hemochromatosis protein


hypoxia response element






inducible nitric oxide


iron response element


iron-regulated protein 1


iron-responsive protein


Kufor-Rakeb syndrome








manganese ethylene-bis-dithiocarbamate


monoamine oxidase


microtubule-associated protein




Mn superoxide dismutase




metal tolerance protein 1


nicotinamide adenine dinucleotide (reduced)


necrosis factor




nitric oxide synthase


National Research Council


oxygen-evolving complex


calcium release-activated calcium channel protein 1


Parkinson’s disease


protein kinase Cd




real-time polymerase chain reaction


Recommended Dietary Allowance


reactive nitrogen species


reactive oxygen species


sarcoplasmic reticulum Ca-ATPase




substantia nigra pars compacta


store-operated Ca2+ channels


superoxide dismutase


mitochondrial superoxide dismutase


single strand breaks


Ca2+ sensor protein




transferrin receptor


tyrosine hydroxylase


tumor necrosis factor α


transient receptor potential cation channel, subfamily M, member 7




untranslated region


zinc transporter


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of Pharmacology and ToxicologyUniversity at Buffalo School of MedicineBuffaloUSA
  2. 2.Departamento de Ciências Fisiológicas, CCBUniversidade Estadual de LondrinaLondrinaBrazil
  3. 3.Department of PediatricsVanderbilt University Medical CenterNashvilleUSA

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