Metallomics and the Cell pp 169-201

Part of the Metal Ions in Life Sciences book series (MILS, volume 12)

Manganese Homeostasis and Transport

Abstract

The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson’s disease (PD) and sensitivity to Mn.

Keywords

divalent metal transporter 1 (DMT1) manganese mitochondria parkin transport Please cite as: Met. Ions Life Sci. 12 (2013) 169–201 

ABBREVIATIONS AND DEFINITIONS

AD

Alzheimer’s disease

A-b

amyloid-b

BBB

blood-brain barrier

BH4

tetrahydrobiopterin

CHOP

C/EBP homologous protein

CNS

central nervous system

DA

dopamine

DAergic

dopaminergic

DARPP-32

dopamine- and cAMP-regulated neuronal phosphoprotein

DAT

dopamine transporter

Dcytb

duodenal cytochrome B

DMT1

divalent metal transporter 1

ER

endoplasmic reticulum

ESADDI

estimated safe and adequate dietary intake

Fpn

ferroportin

GABA

γ-aminobutyric acid

GRP78

glucose-regulated protein 78

GSH

glutathione

HEK293

human embryonic kidney cells 293

HFE

hemochromatosis protein

HRE

hypoxia response element

IL-1β

interleukin-1β

IL-6

interleukin-6

iNOS

inducible nitric oxide

IRE

iron response element

IREG1

iron-regulated protein 1

IRP

iron-responsive protein

KRS

Kufor-Rakeb syndrome

l-dopa

L-3,4-dihydroxyphenylalanine

l-NOARG

NG-nitro-l-arginine

LPS

lipopolysaccharide

Maneb

manganese ethylene-bis-dithiocarbamate

MAO

monoamine oxidase

MAP2

microtubule-associated protein

MDA

malondialdehyde

MnSOD

Mn superoxide dismutase

MPTP

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

MTP1

metal tolerance protein 1

NADH

nicotinamide adenine dinucleotide (reduced)

NF

necrosis factor

NMDA

N-methyl-D-aspartate

NOS

nitric oxide synthase

NRC

National Research Council

OEC

oxygen-evolving complex

ORAI1

calcium release-activated calcium channel protein 1

PD

Parkinson’s disease

PKCd

protein kinase Cd

PQ

paraquat

QPCR

real-time polymerase chain reaction

RDA

Recommended Dietary Allowance

RNS

reactive nitrogen species

ROS

reactive oxygen species

SERCA

sarcoplasmic reticulum Ca-ATPase

SLC39

solute-carrier-39

SNpc

substantia nigra pars compacta

SOC

store-operated Ca2+ channels

SOD

superoxide dismutase

SOD2

mitochondrial superoxide dismutase

SSB

single strand breaks

STIM1

Ca2+ sensor protein

Tf

transferrin

TfR

transferrin receptor

TH

tyrosine hydroxylase

TNFα

tumor necrosis factor α

TRPM7

transient receptor potential cation channel, subfamily M, member 7

Ub

ubiquitin

UTR

untranslated region

ZIP

zinc transporter

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of Pharmacology and ToxicologyUniversity at Buffalo School of MedicineBuffaloUSA
  2. 2.Departamento de Ciências Fisiológicas, CCBUniversidade Estadual de LondrinaLondrinaBrazil
  3. 3.Department of PediatricsVanderbilt University Medical CenterNashvilleUSA

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