Apoptotic Regulators and Its Clinical Implications in Mammary Carcinoma
Today, this is an established fact that like other organs, normal breast development is also used to be monitored by a balance between cell proliferation and apoptosis. As a consequence, tumor growth is not an outcome of abnormal cell proliferation only, but of reduced apoptosis, too. Apoptosis or programmed cell death maintains the integrity of a healthy individual, while dysregulation of this mechanism becomes crucial for the pathophysiology of tumorigenesis. Bcl-2 family of proteins, caspaes, IAP family of proteins, TNF superfamily members are the important regulators of apoptotic signaling pathways. Therefore, several therapeutic agents have been exploited targeting these apoptotic pathways. The review has been concentrated on physiology and pathophysiology of different apoptotic regulators and their therapeutic intervention towards breast cancer.
KeywordsDeath Induce Signaling Complex Extrinsic Apoptotic Pathway Tumor Necrosis Factor Receptor Superfamily Apoptotic Regulator Mammary Gland Involution
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