Treatment of Damaged Brain Following a Stroke: New Strategies

Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 8)

Abstract

Stroke is the second leading cause of death in the world and results in a drastic reduction in the quality of life. New therapeutic strategies for patients suffering from stroke are needed. Possible strategies for treating ischemic stroke include: (i) increasing neuroplasticity (surviving neurons remodel the neuronal network to compensate for impaired neurological function), (ii) enhancement of endogenous neurogenesis (allowing endogenous neural stem cells to give rise to newly born neurons for the repair of disrupted neuronal networks), (iii) stem cell transplantation (supplying exogenous neural stem cells into the infracted lesion for neuronal repair), and (iv) increasing and promoting the mobilization of endothelial progenitors (contributing neuronal repair via enhanced angiogenesis). In the near future, we will combine these strategies to develop more effective therapies for the treatment of strokes.

Keywords

Vascular Endothelial Growth Factor Neural Stem Cell Middle Cerebral Artery Occlusion Endothelial Progenitor Cell Cell Transplantation Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Department of NeurologyOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayamaJapan

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