Attentional Cholinergic Projections May Induce Transitions of Attractor Landscape via Presynaptic Modulations of Connectivity
There is evidence of presynaptic modulation of inhibitions on pyramidal neurons in cortical layers 2/3, mediated by muscarinic M2-receptors activated by transient releases of the corticopetal acetylcholine associated with top-down attention. Little is known, however, regarding its system-level consequences and possible implications for cognitive functions. It is possible that, through a temporal modulation of connectivity between neurons, memory traces or the attractor landscape in the cortex might be significantly affected. We present a hypothetical argument on attractor ruins and temporal reconstructions of attractors by top-down attention. In this paper, we discuss the mathematical validity of this scenario with a computer study using a phase neuron model.
KeywordsTransitions of attractor landscape Presynaptic modulations of connectivity Muscarinic M2-receptors Corticopetal acetylcholine Top-down attention Temporal modulation of connectivity between neurons Temporal reconstruction of attractors Phase neuron model
The authors (H.F. and I.T.) were supported by a Grant-in-Aid for Scientific Research on Innovative Areas “The study on the neural dynamics for understanding communication in terms of complex hetero systems (No.4103)” (21120002) from The Ministry of Education, Culture, Sports, Science, and Technology, Japan. The second author (T.K.) was supported by a Grant-in-Aid for Encouragement of Young Scientists (B) (No. 20700215) from The Ministry of Education, Culture, Sports, Science and Technology of Japan. This research was also partially supported by the Aihara Project, the Funding Program for World-Leading Innovative Research and Development on Science and Technology (FIRST) from the Japan Society for the Promotion of Science (JSPS), initiated by the Council for Science and Technology Policy (CSTP).
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