Plasmodium falciparum: Epigenetic Control of var Gene Regulation and Disease
Plasmodium, one of the most important members of Apicomplexan protozoans imposes a significant economic and health impact on human populations around the world. Plasmodium parasite has complex life cycle with morphologically distinct asexual and sexual developmental stages in the human host and Anopheline mosquito vector. The parasites undergo rapid transition between morphological states and antigenic variation in order to sustain chronic infection and immune evasion in human host. To achieve all these, parasites adopt various regulatory pathways including transcriptional and posttranscriptional regulation of gene expression, translational repression and posttranslational modification of proteins. These regulatory modes help to respond to host conditions during an acute stage infection or life cycle transition of the parasite.
KeywordsHistone Modification Plasmodium Falciparum Histone Acetylation Cerebral Malaria Antigenic Variation
Work in Dhar laboratory is funded by Swarnajayanti Fellowship (Department of Science and Technology, Govt. of India), MALSIG project (European Union), Alexander Von Humboldt Fellowship and National Biosciences award for career development awarded by Dept. of Biotechnology, Government of India. AD and SS acknowledge Council of Scientific and Industrial Research (CSIR), India for fellowships. The authors acknowledge Department of Biotechnology, Government of India for providing the Centre of Excellence in Parasitology grant.
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