Chromatin Structure and Organization: The Relation with Gene Expression During Development and Disease

  • Benoît Moindrot
  • Philippe Bouvet
  • Fabien Mongelard
Chapter
Part of the Subcellular Biochemistry book series (SCBI, volume 61)

Abstract

The elementary level of chromatin fiber, namely the nucleofilament, is known to undergo a hierarchical compaction leading to local chromatin loops, then chromatin domains and ultimately chromosome territories. These successive folding levels rely on the formation of chromatin loops ranging from few kb to some Mb. In addition to a packaging and structural role, the high-order organization of genomes functionally impacts on gene expression program. This review summarises to which extent each level of chromatin compaction does affect gene regulation. In addition, we point out the structural and functional changes observed in diseases. Emphasis will be mainly placed on the large-scale organization of the chromatin.

Keywords

Nuclear Matrix Histone Mark Chromatin Domain Chromosome Territory Endometrial Stromal Sarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We apologize to those whose work could not be discussed here due to space limitations.

The author’s work is supported by grants from Agence Nationale de la Recherche (ANR-07-BLAN-0062-01), Région Rhône-Alpes MIRA 2007 and 2010, Association pour la Recherche sur le Cancer n° ECL2010R01122, CEFIPRA n° 3803-1, and CNRS.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Benoît Moindrot
    • 1
  • Philippe Bouvet
    • 1
  • Fabien Mongelard
    • 1
  1. 1.Laboratoire Joliot-Curie, Centre National de la Recherche Scientifique (CNRS)/Ecole Normale Supérieure de LyonUniversité de LyonLyonFrance

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