G Protein Signaling Components in Filamentous Fungal Genomes

  • Jacqueline A. Servin
  • Asharie J. Campbell
  • Katherine A. Borkovich
Chapter

Abstract

In fungi, heterotrimeric G proteins regulate a number of critical developmental processes including growth, mating and pathogenesis. Signals may originate from extracellular ligands or from internal sources. These signals are conveyed from G protein coupled receptors (GPCRs) or nonreceptor guanine nucleotide exchange factors (GEFs) to a heterotrimeric G protein composed of α, β and γ subunits. GPCRs and nonreceptor GEFs activate the Gα subunit, causing the disassociation of the heterotrimer. Both the Gα and Gβγ heterodimer are free to act upon downstream effectors. Two prominent output pathways are the cyclic adenosine monophosphate (cAMP) and mitogen-activated protein kinase (MAPK) pathways. Changes in growth, mating and pathogenesis can be initiated through G protein signals and executed downstream by these or as yet uncharacterized signaling pathways.

Keywords

Adenylyl Cyclase Pheromone Receptor Opposite Mating Type GTPase Domain Guanine Nucleotide Exchange Factor Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Jacqueline A. Servin
    • 1
  • Asharie J. Campbell
    • 1
  • Katherine A. Borkovich
    • 1
  1. 1.Department of Plant Pathology and Microbiology, Institute of Integrative Genome BiologyUniversity of California, RiversideRiversideUSA

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