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Obesity, Cancer and Psychopathology: Can Vegetarian Diet Be of Help?

  • Vikas KumarEmail author
  • Ajit Kumar Thakur
  • Shyam Sunder Chatterjee
Chapter

Abstract

High body mass index, low fruit and vegetable intake, physical inactivity, tobacco use, alcohol use and unsafe sex are six behaviorally modifiable risk factors potentially involved in increased cancer rates observed during recent years. Numerous epidemiological and experimental data are now beginning to point out that the functions of the central nervous system may also be detrimentally effected by these risk factors, and that complex psychobiological processes are involved in obesity associated comorbidities. Several phytochemicals commonly consumed with fruits and vegetables are known since long to possess chemopreventive as well as beneficial effects on cognitive functions. However, as yet little concentrated efforts have been made to properly understand the health benefits of diverse combinations of phytochemicals commonly consumed with every day meals. Available information on health benefits of some vegetables in obesity associated carcinogenesis are summarized and discussed in short in this chapter. It is concluded that at old fashioned holistic pharmacological approaches could be helpful for identifying effective safe and affordable nutraceuticals and drug leads urgently needed for combating oncological problems associated with obesity.

Keywords

Tuberous Sclerosis Complex Allyl Isothiocyanate Brassica Vegetable Preneoplastic Cell Electrophilic Intermediate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Abate N (1996) Insulin resistance and obesity. The role of fat distribution pattern. Diabetes Care 19(3):292–294PubMedGoogle Scholar
  2. Adam-Rodwell G, Morse MA, Stoner GD (1993) The effects of phenethyl isothiocyanate on benzo[a]pyrene-induced tumors and DNA adducts in A/J mouse lung. Cancer Lett 71(1–3):35–42PubMedGoogle Scholar
  3. Allison DB, Pi-Sunyer FX (1995) Obesity treatment: examining the premises. Endocr Pract 1(5):353–364PubMedGoogle Scholar
  4. Ambrosone CB, McCann SE, Freudenheim JL, Marshall JR, Zhang Y, Shields PG (2004) Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype. J Nutr 134(5):1134–1138PubMedGoogle Scholar
  5. Ames BN, Shigenaga MK, Hagen TM (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A 90(17):7915–7922PubMedGoogle Scholar
  6. Armstrong B, Doll R (1975) Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer 15(4):617–631PubMedGoogle Scholar
  7. Astrinidis A, Henske EP (2005) Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease. Oncogene 24(50):7475–7481PubMedGoogle Scholar
  8. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM (1996) Leptin enters the brain by a saturable system independent of insulin. Peptides 17(2):305–311PubMedGoogle Scholar
  9. Baserga R (1994) Oncogenes and the strategy of growth factors. Cell 79(6):927–930PubMedGoogle Scholar
  10. Belfiore A, Roberta M (2011) The insulin receptor and cancer. Endocr Relat Cancer 18:R125–R147PubMedGoogle Scholar
  11. Bellanger TM, Bray GA (2005) Obesity related morbidity and mortality. J La State Med Soc 157(1):S42–S49PubMedGoogle Scholar
  12. Bergström A, Pisani P, Tenet V, Wolk A, Adami HO (2001) Overweight as an avoidable cause of cancer in Europe. Int J Cancer 91(3):421–430PubMedGoogle Scholar
  13. Boccardo F, Puntoni M, Guglielmini P, Rubagotti A (2006) Enterolactone as a risk factor for breast cancer: a review of the published evidence. Clin Chim Acta 365(1–2):58–67PubMedGoogle Scholar
  14. Boone CW, Kelloff GJ, Malone WE (1990) Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review. Cancer Res 50(1):2–9PubMedGoogle Scholar
  15. Bouloumie A, Drexler HC, Lafontan M, Busse R (1998) Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 83(10):1059–1066PubMedGoogle Scholar
  16. Boutwell RK (1964) Some biological aspects of skin carcinogenisis. Prog Exp Tumor Res 4:207–250PubMedGoogle Scholar
  17. Boyd JN, Babish JG, Stoewsand GS (1982) Modification of beet and cabbage diets of aflatoxin B1-induced rat plasma alpha-foetoprotein elevation, hepatic tumorigenesis, and mutagenicity of urine. Food Chem Toxicol 20(1):47–52PubMedGoogle Scholar
  18. Bråkenhielm E, Veitonmäki N, Cao R, Kihara S, Matsuzawa Y, Zhivotovsky B, Funahashi T, Cao Y (2004) Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci U S A 101(8):2476–2481PubMedGoogle Scholar
  19. Brazil DP, Yang ZZ, Hemmings BA (2004) Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci 29(5):233–242PubMedGoogle Scholar
  20. Brennan AM, Mantzoros CS (2006) Drug insight: the role of leptin in human physiology and pathophysiology – emerging clinical applications. Nat Clin Pract Endocrinol Metab 2(6):318–327PubMedGoogle Scholar
  21. Bresnick E, Birt DF, Wolterman K, Wheeler M, Markin RS (1990) Reduction in mammary tumorigenesis in the rat by cabbage and cabbage residue. Carcinogenesis 11(7):1159–1163PubMedGoogle Scholar
  22. Bruce-Keller AJ, Keller JN, Morrison CD (2009) Obesity and vulnerability of the CNS. Biochim Biophys Acta 1792(5):395–400PubMedGoogle Scholar
  23. Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR, Kley N (1995) Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 377(6550):646–649PubMedGoogle Scholar
  24. Burel C, Boujard T, Kaushik SJ, Boeuf G, Mol KA, Van der Geyten S, Darras VM, Kühn ER, Pradet-Balade B, Quérat B, Quinsac A, Krouti M, Ribaillier D (2001) Effects of rapeseed mealglucosinolates on thyroid metabolism and feed utilization in rainbow trout. Gen Comp Endocrinol 124(3):343–358PubMedGoogle Scholar
  25. Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4(8):579–591PubMedGoogle Scholar
  26. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr (1999) Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 341:1097–1105PubMedGoogle Scholar
  27. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348(17):1625–1638PubMedGoogle Scholar
  28. Ceciliani F, Giordano A, Spagnolo V (2002) The systemic reaction during inflammation: the acute-phase proteins. Protein Pept Lett 9(3):211–223PubMedGoogle Scholar
  29. Chaldakov GN, Tonchev AB, Manni L, Hristova MG, Nikolova V, Fiore M, Vyagova D, Peneva VN, Aloe L (2009) The adipose tissue as a third brain. Obes Metab 5:94–96Google Scholar
  30. Chaldakov GN, Fiore M, Tonchev AB, Aloe L (2010) Neuroadipology: a novel component of neuroendocrinology. Cell Biol Int 34:1051–1053PubMedGoogle Scholar
  31. Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, Hennekens CH, Pollak M (1998) Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 279(5350):563–566PubMedGoogle Scholar
  32. Chang S, Hursting SD, Contois JH, Strom SS, Yamamura Y, Babaian RJ, Troncoso P, Scardino PS, Wheeler TM, Amos CI, Spitz MR (2001) Leptin and prostate cancer. Prostate 46(1):62–67PubMedGoogle Scholar
  33. Chung FL, Kelloff G, Steele V, Pittman B, Zang E, Jiao D, Rigotty J, Choi CI, Rivenson A (1996) Chemopreventive efficacy of arylalkyl isothiocyanates and Nacetylcysteine for lung tumorigenesis in Fischer rats. Cancer Res 56:772–778PubMedGoogle Scholar
  34. Cohen S, Rodriguez MS (1995) Pathways linking affective disturbances and physical disorders. Health Psychol 14(5):374–380PubMedGoogle Scholar
  35. Conaway CC, Yang YM, Chung FL (2002) Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab 3(3):233–255PubMedGoogle Scholar
  36. Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420(6917):860–867PubMedGoogle Scholar
  37. Crandall CS (1991) Do heavy-weight students have more difficulty paying for college? Pers Soc Psychol Bull 17:606–611Google Scholar
  38. Crandall CS, Biernat M (1990) The ideology of anti-fat attitudes. J Appl Soc Psychol 20:227–243Google Scholar
  39. Cruz-Correa M, Shoskes DA, Sanchez P, Zhao R, Hylind LM, Wexner SD, Giardiello FM (2006) Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol 4(8):1035–1038PubMedGoogle Scholar
  40. Davis DL, Bradlow HL, Wolff M, Woodruff T, Hoel DG, Anton-Culver H (1993) Anton-Culver, medical hypothesis: xeno-estrogens as preventable causes of breast cancer. Environ Health Perspect 101(5):372–377PubMedGoogle Scholar
  41. De Flora S, Izzotti A, Bennicelli C (1993) Mechanisms of antimutagenesis and anticarcinogenesis: role in primary prevention. Basic Life Sci 61:1–16PubMedGoogle Scholar
  42. de Zwaan M (2001) Binge eating disorder and obesity. Int J Obes Relat Metab Disord 25(suppl 1):S51–S55PubMedGoogle Scholar
  43. DeWeerdt S (2011) Food: the omnivore’s labyrinth. Nature 471(7339):S22–S24PubMedGoogle Scholar
  44. Diener E, Chan MY (2011) Happy people live longer: subjective well-being contributes to health and longevity. Appl Psychol Health Well-Being Int Assoc Appl Psychol. Blackwell Publishing Ltd., UK 3(1):1–43Google Scholar
  45. Dinarello CA (2000) The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1. N Engl J Med 343(10):732–734PubMedGoogle Scholar
  46. Dunn SE, Kari FW, French J, Leininger JR, Travlos G, Wilson R, Barrett JC (1997) Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res 57(21):4667–4672PubMedGoogle Scholar
  47. Dunn SE, Ehrlich M, Sharp NJ, Reiss K, Solomon G, Hawkins R, Baserga R, Barrett JC (1998) A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer. Cancer Res 58:3353–3361PubMedGoogle Scholar
  48. Elias MF, Elias PK, Sullivan LM, Wolf PA, D’Agostino RB (2003) Lower cognitive function in the presence of obesity and hypertension: the Framingham Heart Study. Int J Obes Relat Metab Disord 27:260–268PubMedGoogle Scholar
  49. Elias MF, Elias PK, Sullivan LM, Wolf PA, D’Agostino RB (2005) Obesity, diabetes and cognitive deficit: the Framingham Heart Study. Neurobiol Aging 26(suppl 1):11–16PubMedGoogle Scholar
  50. Elmquist JK, Bjørbaek C, Ahima RS, Flier JS, Saper CB (1998) Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 395(4):535–547PubMedGoogle Scholar
  51. Engelman JA (2009) Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 9(8):550–562PubMedGoogle Scholar
  52. Etminan M, Takkouche B, Caamano-Isorna F (2004) The role of tomato products and lycopene in the prevention of prostate cancer: a meta-analysis of observational studies. Cancer Epidemiol Biomarkers Prev 13(3):340–345PubMedGoogle Scholar
  53. Faith MS, Allison DB, Geliebter A (1997) Emotional eating and obesity: theoretical considerations and practical recommendations. In: Dalton S (ed) Overweight and weight management: the health professional’s guide to understanding and practice. Aspen, Gaithersburg, pp 439–465. ISBN 9780834206366Google Scholar
  54. Fei H, Okano HJ, Li C, Lee GH, Zhao C, Darnell R, Friedman JM (1997) Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A 94:7001–7005PubMedGoogle Scholar
  55. Fenton JI, Hord NG, Lavigne JA, Perkins SN, Hursting SD (2005) Leptin, insulin-like growth factor-1, and insulin-like growth factor-2 are mitogens in ApcMin/+ but not Apc+/+ colonic epithelial cell lines. Cancer Epidemiol Biomarkers Prev 14(7):1646–1652PubMedGoogle Scholar
  56. Ferguson PJ, Kurowska E, Freeman DJ, Chambers AF, Koropatnick DJ (2004) A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines. J Nutr 134(6):1529–1535PubMedGoogle Scholar
  57. Fitzgibbon ML, Stolley MR, Kirschenbaum DS (1993) Obese people who seek treatment have different characteristics than those who do not seek treatment. Health Psychol 12(5):342–345PubMedGoogle Scholar
  58. Franke TF (2008) PI3K/Akt: getting it right matters. Oncogene 27(50):6473–6488PubMedGoogle Scholar
  59. Fraser GE (1999) Associations between diet and cancer, ischemic heart disease, and allcause mortality in non-Hispanic white California Seventh-day Adventists. Am J Clin Nutr 20(suppl 3):532s–538sGoogle Scholar
  60. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395(6704):763–770PubMedGoogle Scholar
  61. Friedman KE, Reichmann SK, Costanzo PR, Musante GJ (2002) Body image partially mediates the relationship between obesity and psychological distress. Obes Res 10(1):33–41PubMedGoogle Scholar
  62. Gerson M (1978) The cure of advanced cancer by diet therapy: a summary of 30 years of clinical experimentation. Physiol Chem Phys 10(5):449–464PubMedGoogle Scholar
  63. Giovannucci E, Pollak MN, Platz EA, Willett WC, Stampfer MJ, Majeed N, Colditz GA, Speizer FE, Hankinson SE (2000) A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women. Cancer Epidemiol Biomarkers Prev 9(4):345–349PubMedGoogle Scholar
  64. Gomez-Pinilla F (2008) The influences of diet and exercise on mental health through hormesis. Ageing Res Rev 7(1):49–62PubMedGoogle Scholar
  65. Gonzalez RR, Cherfils S, Escobar M, Yoo JH, Carino C, Styer AK, Sullivan BT, Sakamoto H, Olawaiye A, Serikawa T, Lynch MP, Rueda BR (2006) Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). J Biol Chem 281(36):26320–26328PubMedGoogle Scholar
  66. Gortmaker SL, Must A, Perrin JM, Sobol AM, Dietz WH (1993) Social and economic consequences of overweight in adolescence and young adulthood. N Engl J Med 329:1008–1012PubMedGoogle Scholar
  67. Greer S (1983) Cancer and the mind. Maudsley Bequest Lecture delivered before the Royal College of Psychiatrists, February 1983. Br J Psychiatry 143:535–543PubMedGoogle Scholar
  68. Grimm JJ (1999) Interaction of physical activity and diet: implications for insulin-glucose dynamics. Public Health Nutr 2(3A):363–368PubMedGoogle Scholar
  69. Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140(6):883–899PubMedGoogle Scholar
  70. Grossmann ME, Nkhata KJ, Mizuno NK, Ray A, Cleary MP (2008) Effects of adiponectin on breast cancer cell growth and signaling. Br J Cancer 98(2):370–379PubMedGoogle Scholar
  71. Guertin DA, Sabatini DM (2005) An expanding role for mTOR in cancer. Trends Mol Med 11(8):353–361PubMedGoogle Scholar
  72. Gunstad J, Paul RH, Cohen RA, Tate DF, Spitznagel MB, Gordon E (2007) Elevated body mass index is associated with executive dysfunction in otherwise healthy adults. Compr Psychiatry 48(1):57–61PubMedGoogle Scholar
  73. Guo D, Schut HA, Davis CD, Snyderwine EG, Bailey GS, Dashwood RH (1995) Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinognesis 16(12):2931–2937Google Scholar
  74. Haan MN, Wallace R (2004) Can dementia be prevented? Brain aging in a population-based context. Annu Rev Public Health 25:1–24PubMedGoogle Scholar
  75. Hankinson SE, Willett WC, Colditz GA, Hunter DJ, Michaud DS, Deroo B, Rosner B, Speizer FE, Pollak M (1998) Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 351(9113):1393–1396PubMedGoogle Scholar
  76. Harris CC (1991) Chemical and physical carcinogenesis: advances and perspectives for the 1990s. Cancer Res 51(suppl 18):5023s–5044sPubMedGoogle Scholar
  77. Hartwell JL (1982) Plants used against cancer: a survey. Quarterman Publications, Lawrence, pp 438–439. ISBN 0880001305Google Scholar
  78. Harvey J (2007) Leptin regulation of neuronal excitability and cognitive function. Curr Opin Pharmacol 7(6):643–647PubMedGoogle Scholar
  79. Hemminki K, Sundquist J, Sundquist K (2011) Obesity and familial obesity and risk of cancer. Eur J Cancer Prev 20(5):438–443PubMedGoogle Scholar
  80. Higdon JV, Delage B, Williams DE, Dashwood RH (2007) Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res 55(3):224–236PubMedGoogle Scholar
  81. Hill CB, Williams PH, Carlson DG, Tookey HL (1987) Variation in glucosinolates in oriental brassica vegetables. J Am Soc Hortic Sci 112(2):309–313Google Scholar
  82. Holman DW, White MC (2011) Dietary behaviors related to cancer prevention among pre-adolescents and adolescents: the gap between recommendations and reality. Nutr J 10:60PubMedGoogle Scholar
  83. Hursting SD, Switzer BR, French JE, Kari FW (1993) The growth hormone: insulin-like growth factor 1 axis is a mediator of diet restriction-induced inhibition of mononuclear cell leukemia in Fischer rats. Cancer Res 53(12):2750–2757PubMedGoogle Scholar
  84. Hursting SD, Perkins SN, Brown CC, Haines DC, Phang JM (1997) Calorie restriction induces a p53-independent delay of spontaneous carcinogenesis in p53-deficient and wild-type mice. Cancer Res 57(14):2843–2846PubMedGoogle Scholar
  85. Hursting SD, Lavigne JA, Berrigan D, Perkins SN, Barrett JC (2003) Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. Annu Rev Med 54:131–152PubMedGoogle Scholar
  86. Hursting SD, Nunez NP, Varticovski L, Vinson C (2007) The obesity-cancer link: lessons learned from a fatless mouse. Cancer Res 67(6):2391–2393PubMedGoogle Scholar
  87. Hursting SD, Smith SM, Lashinger LM, Harvey AE, Perkins SN (2010) Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research. Carcinogenesis 31(1):83–89PubMedGoogle Scholar
  88. Inoki K, Corradetti MN, Guan KL (2005) Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 37(1):19–24PubMedGoogle Scholar
  89. Istvan J, Zavela K, Weidner G (1992) Body weight and psychological distress in the NHANES I. Int J Obes Relat Metab Disord 16(12):999–1003PubMedGoogle Scholar
  90. Jacobs DR, Gross MD, Tapsell LC (2009) Food synergy: an operational concept for understanding nutrition. Am J Clin Nutr 89(5):1543S–1548SPubMedGoogle Scholar
  91. Jakoby WB (1980) Enzymatic basis of detoxification, vol I and II. Academic, New York (Vol I-0123800013), (Vol II-0123800021)Google Scholar
  92. Johansson G (2011) Dietary advice on prescription: a novel approach to dietary counseling. Int J Qual Stud Health Well-being 6(2). doi:10.3402/qhw.v6i2.7136Google Scholar
  93. Kaaks R, Lukanova A, Kurzer MS (2002) Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev 11(12):1531–1543PubMedGoogle Scholar
  94. Kaminsky J, Gadaleta D (2002) A study of discrimination within the medical community as viewed by obese patients. Obes Surg 12(1):14–18PubMedGoogle Scholar
  95. Kassie F, Pool-Zobel B, Parzefall W, Knasmuller S (1999) Genotoxic effects of benzyl isothiocyanate, a natural chemopreventive agent. Mutagenesis 14(6):595–604PubMedGoogle Scholar
  96. Key TJ (2011) Fruits and vegetables and cancer risk. Br J Cancer 104(1):6–11PubMedGoogle Scholar
  97. Kim DJ, Lee KK, Han BS, Ahn B, Bae JH, Jang JJ (1994) Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine- induced preneoplastic glutathione S-transferase placenta form-positive liver cell foci in Sprague Dawley rat. Jpn J Cancer Res 85(6):578–583PubMedGoogle Scholar
  98. Kim JE, Jung MJ, Jung HA, Woo JJ, Cheigh HS, Chung HY, Choi JS (2002) A new kaempferol 7-O-triglucoside from the leaves of Brassica juncea L. Arch Pharm Res 25(5):621–624PubMedGoogle Scholar
  99. Kivimäki M, Lawlor DA, Singh-Manoux A, Batty GD, Ferrie JE, Shipley MJ, Nabi H, Sabia S, Marmot MG, Jokela M (2009) Common mental disorder and obesity: insight from four repeat measures over 19 years: prospective Whitehall II cohort study. BMJ 339:b3765. doi:10.1136/bmj.b3765PubMedGoogle Scholar
  100. Knecht S, Ellger T, Levine JA (2008) Obesity in neurobiology. Prog Neurobiol 84:85–103PubMedGoogle Scholar
  101. Krishnaswamy K, Polasa K (1995) Diet, nutrition & cancer–the Indian scenario. Indian J Med Res 102:200–209PubMedGoogle Scholar
  102. Kushi LH, Byers T, Doyle C, Bandera EV, McCullough M, McTiernan A, Gansler T, Andrews KS, Thun MJ, American Cancer Society, Nutrition and Physical Activity Guidelines Advisory Committee (2006) American cancer society guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin 56(5):254–281PubMedGoogle Scholar
  103. Larkin JC, Pines HA (1979) No fat persons need apply: experimental studies of the overweight stereotype and hiring preference. Work Occup 6(3):312–327Google Scholar
  104. LeRoith D, Baserga R, Helman L, Roberts CT (1995) Insulin-like growth factors and cancer. Ann Intern Med 122(1):54–59PubMedGoogle Scholar
  105. Lew EA, Garfinkel L (1979) Variations in mortality by weight among 750,000 men and women. J Chron Dis 32(8):563–576PubMedGoogle Scholar
  106. Lin J, Wang J, Greisinger AJ, Grossman HB, Forman MR, Dinney CP, Hawk ET, Wu X (2010) Energy balance, the PI3K-AKT-mTOR pathway genes, and the risk of bladder cancer. Cancer Prev Res (Phila) 3(4):505–517Google Scholar
  107. Lindsted KD, Singh PN (1998) Body mass and 26 y risk of mortality among men who never smoked: a re-analysis among men from the Adventist Mortality Study. Int J Obes Relat Metab Disord 22(6):544–548PubMedGoogle Scholar
  108. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN (2002) Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci U S A 99(4):2356–2361PubMedGoogle Scholar
  109. Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, Lane MD, Diehl AM (1998) Leptin regulates proinflammatory immune responses. FASEB J 12(1):57–65PubMedGoogle Scholar
  110. Lonnqvist F, Wennlund A, Arner P (1997) Relationship between circulating leptin and peripheral fat distribution in obese subjects. Int J Obes Relat Metab Disord 21(4):255–260PubMedGoogle Scholar
  111. Lovestone S, Fahy T (1991) Psychological factors in breast cancer. BMJ 302(6787):1219–1220PubMedGoogle Scholar
  112. Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR (2007) Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 56(1):16–23PubMedGoogle Scholar
  113. Luppino FS, de Witt LM, Stijnen T, Cuijpers P, Penninx BW, Zitman FG (2010) Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry 67(3):220–229PubMedGoogle Scholar
  114. Ma J, Pollak MN, Giovannucci E, Chan JM, Tao Y, Hennekens CH, Stampfer MJ (1999) Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst 91(7):620–625PubMedGoogle Scholar
  115. Macaulay VM (1992) Insulin-like growth factors and cancer. Br J Cancer 65(3):311–320PubMedGoogle Scholar
  116. Macready AL, Kennedy OB, Ellis JA, Williams CM et al (2009) Flavonoids and cognitive function: a review of human randomized control trial studies and recommendations for future studies. Gene Nutr 4(4):227–242Google Scholar
  117. Magee PJ, Rowland IR (2004) Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer. Br J Nutr 91(4):513–531PubMedGoogle Scholar
  118. Manson JE, Willett WC, Stampfer MJ, Colditz GA, Hunter DJ, Hankinson SE, Hennekens CH, Speizer FE (1995) Body weight and mortality among women. N Engl J Med 333(11):677–685PubMedGoogle Scholar
  119. Martin C, Butelli E, Petroni K, Tonelli C (2011) How can research on plants contribute to promoting human health? Plant Cell 23(5):1685–1699PubMedGoogle Scholar
  120. Mattson MP, Duan W, Guo Z (2003) Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms. J Neurochem 84(3):417–431PubMedGoogle Scholar
  121. Mawson R, Heaney RK, Zdunczyk Z, Kozłowska H (1994a) Rapeseed meal glucosinolates and their antinutritional effects. Part 3. Animal growth and performance. Nahrung 38(2):167–177PubMedGoogle Scholar
  122. Mawson R, Heaney RK, Zdunczyk Z, Kozłowska H (1994b) Rapeseed meal glucosinolates and their antinutritional effects. Part 4. Goitrogenicity and internal organs abnormalities in animals. Nahrung 38(2):178–191PubMedGoogle Scholar
  123. McAllister EJ, Dhurandhar NV, Keith SW, Aronne LJ, Barger J, Baskin M, Benca RM, Biggio J, Boggiano MM, Eisenmann JC, Elobeid M, Fontaine KR, Gluckman P, Hanlon EC, Katzmarzyk P, Pietrobelli A, Redden DT, Ruden DM, Wang C, Waterland RA, Wright SM, Allison DB (2009) Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr 49(10):868–913PubMedGoogle Scholar
  124. McCann MJ, Gill CI, McGlynn H, Rowland IR (2005) Role of mammalian lignans in the prevention and treatment of prostate cancer. Nutr Cancer 52(1):1–14PubMedGoogle Scholar
  125. McDanell R, McLean AE, Hanley AB, Heaney RK, Fenwick GR (1988) Chemical and biological properties of indole glucosinolates (glucobrassicins): a review. Food Chem Toxicol 26(1):59–70PubMedGoogle Scholar
  126. Mithen RF, Dekker M, Verkerk R, Rabot S, Johnson IT (2000) The nutritional significance, biosynthesis and bioavailability of glucosinolates in human food. J Sci Food Agric 80(7):967–984Google Scholar
  127. Mittendorfer B, Magkos F, Fabbrini E, Mohammed BS, Klein S (2009) Relationship between body fat mass and free fatty acid kinetics in men and women. Obesity (Silver Spring) 17(10):1872–1877Google Scholar
  128. Moiseeva EP, Manson MM (2009) Dietary chemopreventive phytochemicals: too little or too much? Cancer Prev Res (Phila) 2:611–616Google Scholar
  129. Montague CT, Prins JB, Sanders L, Digby JE, O’Rahilly S (1997) Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes 46(3):342–347PubMedGoogle Scholar
  130. Moore ME, Stunkard A, Srole L (1962) Obesity, social class, and mental illness. JAMA 181:962–966PubMedGoogle Scholar
  131. Moore KW, O’Garra A, de Waal MR, Vieira P, Mosmann TR (1993) Interleukin-10. Annu Rev Immunol 11:165–190PubMedGoogle Scholar
  132. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS (2006) Association of vegetables and fruit consumption with age related cognitive functions. Neurology 67(8):1370–1376PubMedGoogle Scholar
  133. Musante GJ, Costanzo PR, Friedman KE (1998) The comorbidity of depression and eating dysregulation processes in a diet-seeking obese population: a matter of gender specificity. Int J Eat Disord 23(1):65–75PubMedGoogle Scholar
  134. National Institutes of Health (NIH) (1998) Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. The evidence report. Obes Res 6(suppl 2):51S–209SGoogle Scholar
  135. National Task Force on the Prevention and Treatment of Obesity (NTFPTO) (2000) Overweight, obesity, and health risk. Arch Intern Med 160(7):898–904Google Scholar
  136. National Toxicology Program (NTP) (1982) Carcinogenesis bioassay of allyl isothiocyanate (CAS No. 57-06-7) in F344N rats and B6C3F1 mice (gavage study). Technical report series no. 234. NIH publication no. 83–1790Google Scholar
  137. Nordic Council of Ministers (NCM) (1994) Naturally occurring antitumourigens, vol 2, Organic isothiocyanates. TemaNord, Copenhagen. ISBN 9291204560Google Scholar
  138. Ostlund RE, Yang JW, Klein S, Gingerich R (1996) Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab 81(11):3909–3913PubMedGoogle Scholar
  139. Pang TY, Hannan AJ (2010) Environmental enrichment: a cure for cancer? It’s all in mind. J Mol Cell Biol 2:302–304PubMedGoogle Scholar
  140. Park J, Rho HK, Kim KH, Choe SS, Lee YS, Kim JB (2005) Overexpression of glucose-6-phosphate dehydrogenase is associated with lipid dysregulation and insulin resistance in obesity. Mol Cell Biol 25(12):5146–5157PubMedGoogle Scholar
  141. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55(2):74–108PubMedGoogle Scholar
  142. Peeters PH, Keinan-Boker L, van der Schouw YT, Grobbee DE (2003) Phytoestrogens and breast cancer risk. Review of the epidemiological evidence. Breast Cancer Res Treat 77(2):171–183PubMedGoogle Scholar
  143. Perkins S, Verschoyle RD, Hill K, Parveen I, Threadgill MD, Sharma RA, Williams ML, Steward WP, Gescher AJ (2002) Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev 11(6):535–540PubMedGoogle Scholar
  144. Petridou E, Dessypris N, Spanos E, Mantzoros C, Skalkidou A, Kalmanti M, Koliouskas D, Kosmidis H, Panagiotou JP, Piperopoulou F, Tzortzatou F, Trichopoulos D (1999) Insulin-like growth factor-I and binding protein-3 in relation to childhood leukaemia. Int J Cancer 80(4):494–496PubMedGoogle Scholar
  145. Phillips F, Hackett AF, Stratton G, Billington D (2004) Effects of changing from a mixed to self-selected vegetarian diet on anthropometric measurements in UK adults. J Hum Nutr Diet 17(3):249–255PubMedGoogle Scholar
  146. Pingitore R, Dugoni BL, Tindale RS, Spring B (1994) Bias against overweight job applicants in a simulated employment interview. J Appl Psychol 79(6):909–917PubMedGoogle Scholar
  147. Pollak MN, Schernhammer ES, Hankinson SE (2004) Insulin-like growth factors and neoplasia. Nat Rev Cancer 4(7):505–518PubMedGoogle Scholar
  148. Porzelius LK, Houston C, Smith M, Arfken C, Fisher E (1995) Comparison of a standard behavioral weight loss treatment and a binge eating weight loss treatment. Behav Ther 26(1):119–134Google Scholar
  149. Prather RC, Williamson DA (1988) Psychopathology associated with bulimia, binge eating, and obesity. Int J Eat Disord 7:177–184Google Scholar
  150. Pretolani M (1999) Interleukin-10: an anti-inflammatory cytokine with therapeutic potential. Clin Exp Allergy 29(9):1164–1171PubMedGoogle Scholar
  151. Qiu C, De Ronchi D, Fratiglioni L (2007) The epidemiology of the dementias: an update. Curr Opin Psychiatry 20(4):380–385PubMedGoogle Scholar
  152. Rajala MW, Scherer PE (2003) Minireview: the adipocyte at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144(9):3765–3773PubMedGoogle Scholar
  153. Rand CS, Macgregor AM (1990) Morbidly obese patients’ perceptions of social discrimination before and after surgery for obesity. South Med J 83(12):1390–1395PubMedGoogle Scholar
  154. Rao CV, Rivenson A, Simi B, Zang E, Hamid R, Kelloff GJ, Steele V, Reddy BS (1995) Enhancement of experimental colon carcinogenesis by dietary 6-phenylhexyl isothiocyanates. Cancer Res 55(19):4311–4318PubMedGoogle Scholar
  155. Ray A, Nkhata KJ, Cleary MP (2007) Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status. Int J Oncol 30(6):1499–1509PubMedGoogle Scholar
  156. Reaven GM (1988) Banting lecture (1988). Role of insulin resistance in human disease. Diabetes 37(12):1595–1607PubMedGoogle Scholar
  157. Renehan AG (2010) Obesity and cancer. In: Leff T, Granneman JG (eds) Adipose tissue in health and disease. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. ISBN 9783527629527Google Scholar
  158. Renehan AG (2011) The epidemiology of overweight/obesity and cancer. In: McTiernan A (ed) Physical activity, dietary calories restriction, and cancer, vol 3, Energy balance and cancer. Springer, New York, pp 5–23Google Scholar
  159. Renehan AG, Roberts DL, Dive C (2008) Obesity and cancer: pathophysiological and biological mechanisms. Arch Physiol Biochem 114(1):71–83PubMedGoogle Scholar
  160. Renehan AG, Soerjomataram I, Leitzmann MF (2010) Interpreting the epidemiological evidence linking obesity and cancer: a framework for population-attributable risk estimations in Europe. Eur J Cancer 46(14):2581–2592PubMedGoogle Scholar
  161. Resnicoff M, Abraham D, Yutanawiboonchai W, Rotman HL, Kajstura J, Rubin R, Zoltick P, Baserga R (1995) The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Res 55(11):2463–2469PubMedGoogle Scholar
  162. Roberts DL, Dive C, Renehan AG (2010) Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med 61:301–316PubMedGoogle Scholar
  163. Roe DA, Eickwort KR (1976) Relationships between obesity and associated health factors with unemployment among low income women. J Am Med Womens Assoc 31(5):193–194PubMedGoogle Scholar
  164. Rosell M, Appleby P, Spencer E, Key T (2006) Weight gain over 5 years in 21,966 meat-eating, fish-eating, vegetarian, and vegan men and women in EPIC-Oxford. Int J Obes (Lond) 30(9):1389–1396Google Scholar
  165. Saglam K, Aydur E, Yilmaz M, Goktaş S (2003) Leptin influences cellular differentiation and progression in prostate cancer. J Urol 169(4):1308–1311PubMedGoogle Scholar
  166. Sang JP, Minchinton IR, Johnstone PK, Truscott RJ (1984) Glucosinolates profiles in the seed, root and leaf tissue of cabbage, mustard, rapeseed, radish and swede. Can J Plant Sci 64:77–93Google Scholar
  167. Sara VR, Hall K (1990) Insulin-like growth factors and their binding proteins. Physiol Rev 70(3):591–614PubMedGoogle Scholar
  168. Sargent JD, Blanchflower DG (1994) Obesity and stature in adolescence and earnings in young adulthood. Analysis of a British birth cohort. Arch Pediatr Adolesc Med 148(7):681–687PubMedGoogle Scholar
  169. Sarwer DB, Wadden TA, Foster GD (1998) Assessment of body image dissatisfaction in obese women: specificity, severity, and clinical significance. J Consult Clin Psychol 66(4):651–654PubMedGoogle Scholar
  170. Scarborough P, Nnoaham KE, Clarke D, Capewell S, Rayner M (2010) Modelling the impact of a healthy diet on cardiovascular disease and cancer mortality. J Epidemiol Community Health. doi:10.1136/jech.2010.114520Google Scholar
  171. Schaefer EJ (2002) Lipoproteins, nutrition and heart disease. Am J Clin Nutr 75(2):191–212PubMedGoogle Scholar
  172. Scholar EM, Wolterman K, Birt DF, Bresnick E (1989) The effect of diets enriched in cabbage and collards on mtLrine pulmonary metastasis. Nutr Cancer 12(2):121–126PubMedGoogle Scholar
  173. Shoeb M (2006) Anticancer agents from medicinal plants. Bangladesh J Pharmacol 1:35–41Google Scholar
  174. Singh P, Dai B, Yallampalli U, Lu X, Schroy PC (1996) Proliferation and differentiation of a human colon cancer cell line (CaCo2) is associated with significant changes in the expression and secretion of insulin-like growth factor (IGF) IGF-II and IGF binding protein-4: role of IGF-II. Endocrinology 137(5):1764–1774PubMedGoogle Scholar
  175. Sinha R, Anderson DE, McDonald SS, Greenwald P (2003) Cancer risk and diet in India. J Postgrad Med 49(3):222–228PubMedGoogle Scholar
  176. Smith DE, Marcus MD, Lewis CE, Fitzgibbon M, Schreiner P (1998) Prevalence of binge eating disorder, obesity, and depression in a biracial cohort of young adults. Ann Behav Med 20(3):227–232PubMedGoogle Scholar
  177. Smith DE, Thompson JK, Raczynski JM, Hilner JE (1999) Body image among men and women in a biracial cohort: the CARDIA study. Int J Eat Disord 25(1):71–82PubMedGoogle Scholar
  178. Spiegel D (2011) Mind matters in cancer survival. JAMA 305(5):502–503PubMedGoogle Scholar
  179. Srisangam C, Hendricks DG, Sharma RP, Salunkhe DK, Mahoney AW (1980) Effects of dietary cabbage on the tumorigenicity of 1,2-dimethylhydrazine in mice. J Food Saf 2(4):235–245Google Scholar
  180. Stattin P, Lukanova A, Biessy C, Söderberg S, Palmqvist R, Kaaks R, Olsson T, Jellum E (2004) Obesity and colon cancer: does leptin provide a link? Int J Cancer 109(1):149–152PubMedGoogle Scholar
  181. Stevens J, Plankey MW, Williamson DF, Thun MJ, Rust PF, Palesch Y, O’Neil PM (1998) The body mass index-mortality relationship in white and African American women. Obesity 6(4):268–277Google Scholar
  182. Stoewsand GS, Babish JB, Wimberly HC (1978) Inhibition of hepatic toxicities from polybrominated biphenyls and aflatoxin B1 in rats fed cauliflower. J Environ Pathol Toxicol 2(2):399–406PubMedGoogle Scholar
  183. Stoewsand GS, Anderson JL, Munson L (1988) Protective effect of dietary Brussels sprouts against mammary carcinogenesis in Sprague-Dawley rats. Cancer Lett 39(2):199–207PubMedGoogle Scholar
  184. Stoner G, Casto B, Ralston S, Roebuck B, Pereira C, Bailey G (2002) Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol. Carcinogenesis 23(2):265–272PubMedGoogle Scholar
  185. Stunkard AJ, Rush J (1974) Dieting and depression reexamined: a critical review of reports of untoward responses during weight reduction for obesity. Ann Int Med 81(4):526–533PubMedGoogle Scholar
  186. Stunkard AJ, Wadden TA (1992) Psychological aspects of severe obesity. Am J Clin Nutr 55(suppl 2):524s–532sPubMedGoogle Scholar
  187. Takahashi K, Suzuki K (1993) Association of insulin-like growth-factor-I-induced DNA synthesis with phosphorylation and nuclear exclusion of p53 in human breast cancer MCF-7 cells. Int J Cancer 55(3):453–458PubMedGoogle Scholar
  188. Tanco S, Linden W, Earle T (1998) Well-being and morbid obesity in women: a controlled therapy evaluation. Int J Eat Disord 23(3):325–339PubMedGoogle Scholar
  189. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83(7):1263–1271PubMedGoogle Scholar
  190. Tee AR, Blenis J (2005) mTOR, translational control and human disease. Semin Cell Dev Biol 16(1):29–37PubMedGoogle Scholar
  191. Telch CF, Agras WS (1994) Obesity, binge eating and psychopathology: are they related? Int J Eat Disord 15(1):53–61PubMedGoogle Scholar
  192. Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363(8):733–742PubMedGoogle Scholar
  193. Thakur AK, Kumar V (2010a) Beneficial effect of Brassica juncea in co-morbid anxiety associated with alloxan induced diabetes in rats. Indian J Pharmacol 42(suppl 2):S223Google Scholar
  194. Thakur AK, Kumar V (2010b) Beneficial effect of Brassica juncea in co-morbid depression associated with alloxan induced diabetes in rodents. Poster presented during international conference on recent advances in pharmaceutical sciences, 22–23 Dec 2010. Organized by the Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, VaranasiGoogle Scholar
  195. Tilg H, Dinarello CA, Mier JW (1997) IL-6 and APPs: anti-inflammatory and immunosuppressive mediators. Immunol Today 18(9):428–432PubMedGoogle Scholar
  196. Troisi A, Scucchi S, San Martino L, Montera P, d’Amore A, Moles A (2001) Age specificity of the relationship between serum cholesterol and mood in obese women. Physiol Behav 72(3):409–413PubMedGoogle Scholar
  197. Tseng SH, Lin SM, Chen JC, Su YH, Huang HY, Chen CK, Lin PY, Chen Y (2004) Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats. Clin Cancer Res 10(6):2190–2202PubMedGoogle Scholar
  198. Vainio H, Bianchini F (eds) (2002) IARC handbook of cancer prevention, vol 6, Weight control and physical activity. IARC Press, Lyon. ISBN 9789283230069Google Scholar
  199. Vijayaraghavan K, Rao DH (1998) Diet & nutrition situation in rural India. Indian J Med Res 108:243–253PubMedGoogle Scholar
  200. Villanueva EC, Myers MG (2008) Leptin receptor signaling and the regulation of mammalian physiology. Int J Obes (Lond) 32(Suppl 7):S8–S12Google Scholar
  201. Waldstein SR, Katzel LI (2006) Interactive relations of central versus total obesity and blood pressure to cognitive function. Int J Obes (Lond) 30(1):201–207Google Scholar
  202. Wattenberg LW (1983) Inhibition of neoplasia by minor dietary constituents. Cancer Res 43(suppl 5):2448s–2453sPubMedGoogle Scholar
  203. Wattenberg LW (1992) Inhibition of carcinogenesis by minor dietary constituents. Cancer Res 52(suppl 7):2085s–2091sPubMedGoogle Scholar
  204. Wattenberg LW, Sachafer HW, Water L, Davis DW (1989) Inhibition of mammary tumor formation by broccoli and cabbage. Proc Am Assoc Cancer Res 30:181–188Google Scholar
  205. Willett WC, Manson JE, Stampfer MJ, Colditz GA, Rosner B, Speizer FE, Hennekens CH (1995) Weight, weight change, and coronary heart disease in women. Risk within the ‘normal’ weight range. JAMA 273(6):461–465PubMedGoogle Scholar
  206. Wolin KY, Carson K, Colditz GA (2010) Obesity and cancer. Oncologist 15(6):556–565PubMedGoogle Scholar
  207. Wolk A, Gridley G, Svensson M, Nyrén O, McLaughlin JK, Fraumeni JF, Adam HO (2001) A prospective study of obesity and cancer risk (Sweden). Cancer Causes Control 12(1):13–21PubMedGoogle Scholar
  208. Woods SC, Seeley RJ, Porte D, Schwartz MW (1998) Signals that regulate food intake and energy homeostasis. Science 280(5368):1378–1383PubMedGoogle Scholar
  209. Wooley SC, Garner DM (1991) Obesity treatment: the high cost of false hope. J Am Diet Assoc 91(10):1248–1251PubMedGoogle Scholar
  210. World Cancer Research Fund / American Institute for Cancer Research (WCRF/AICR) (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. AICR, Washington, DC. ISBN 9780972252225Google Scholar
  211. World Health Organization (WHO) (2000) Obesity: preventing and managing the global epidemic. World Health Organization technical reprints series no. 894, i–xii, pp 1–253. ISBN: 9789241208949Google Scholar
  212. Yakar S, Leroith D, Brodt P (2005) The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: lessons from animal models. Cytokine Growth Factor Rev 16(4–5):407–420PubMedGoogle Scholar
  213. Yokozawa T, Kim HY, Cho EJ, Choi JS, Chung HY (2002) Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes. J Agric Food Chem 50(19):5490–5495PubMedGoogle Scholar
  214. Yoon BH, Jung JW, Lee JJ, Cho YW, Jang CG, Jin C, Oh TH, Ryu JH (2007) Anxiolytic-like effects of sinapic acid in mice. Life Sci 81(3):234–240PubMedGoogle Scholar
  215. Yoshida M, Katashima S, Ando J, Tanaka T, Uematsu F, Nakae D, Maekawa A (2004) Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with Nethyl- N′-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism. Carcinogenesis 25(11):2257–2264PubMedGoogle Scholar
  216. Yu H, Spitz MR, Mistry J, Gu J, Hong WK, Wu X (1999) Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis. J Natl Cancer Inst 91(2):151–156PubMedGoogle Scholar
  217. Yuan TL, Cantley LC (2008) PI3K pathway alterations in cancer: variations on a theme. Oncogene 27(41):5497–5510PubMedGoogle Scholar
  218. Zhang Y, Leibel R (1998) Molecular physiology of leptin and its receptor. Growth Genet Horm 14:17–35Google Scholar
  219. Zhang Y, Talalay P (1994) Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms. Cancer Res 5(suppl 7):1976s–1981sGoogle Scholar
  220. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nat Neurosci 372(6505):425–432Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Vikas Kumar
    • 1
    Email author
  • Ajit Kumar Thakur
    • 1
  • Shyam Sunder Chatterjee
    • 2
  1. 1.Neuropharmacology Research Laboratory, Department of Pharmaceutics, Institute of TechnologyBanaras Hindu UniversityVaranasiIndia
  2. 2.Retired Head of Pharmacology Research LaboratoriesDr. Willmar Schwabe GmbH & Co. KG.KarlsruheGermany

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