Calcium Signaling pp 1175-1191 | Cite as

Proarrhythmic Atrial Calcium Cycling in the Diseased Heart

Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 740)

Abstract

During the last decades Ca2+ has been found to play a crucial role in cardiac arrhythmias associated with heart failure and a number of congenital arrhythmia syndromes. Recent studies demonstrated that altered atrial Ca2+ cycling may promote the initiation and maintenance of atrial fibrillation, the most common clinical arrhythmia that contributes significantly to population morbidity and mortality. This article describes physiological Ca2+ cycling mechanisms in atrial cardiomyocytes and relates them to fundamental cellular proarrhythmic mechanisms involving Ca2+ signaling abnormalities in the atrium during atrial fibrillation.

Keywords

Calcium Atrial arrhythmias Remodeling Ion channels Reentry Triggered activity 

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Division of Experimental Cardiology, Medical Faculty MannheimUniversity of HeidelbergMannheimGermany
  2. 2.Montreal Heart InstituteUniversity of Montreal and Research CenterMontrealCanada

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