Chapter

Calcium Signaling

Volume 740 of the series Advances in Experimental Medicine and Biology pp 891-916

Date:

Stem Cells and Calcium Signaling

  • Fernanda M. P. TonelliAffiliated withUniversidade Federal de São João Del Rei Campus Alto Paraopeba
  • , Anderson K. SantosAffiliated withUniversidade Federal de São João Del Rei Campus Alto Paraopeba
  • , Dawidson A. GomesAffiliated withDepartment of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais
  • , Saulo L. da SilvaAffiliated withUniversidade Federal de São João Del Rei Campus Alto Paraopeba
  • , Katia N. GomesAffiliated withNanomaterials Laboratory, Department of Physics, Institute of Exact Sciences, Federal University of Minas Gerais
  • , Luiz O. LadeiraAffiliated withUniversidade Federal de São João Del Rei Campus Alto Paraopeba
  • , Rodrigo R. ResendeAffiliated withUniversidade Federal de São João Del Rei Campus Alto ParaopebaNanomaterials Laboratory, Department of Physics, Institute of Exact Sciences, Federal University of Minas Gerais Email author 

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Abstract

The increasing interest in stem cell research is linked to the promise of developing treatments for many lifethreatening, debilitating diseases, and for cell replacement therapies. However, performing these therapeutic innovations with safety will only be possible when an accurate knowledge about the molecular signals that promote the desired cell fate is reached. Among these signals are transient changes in intracellular Ca2+ concentration [Ca2+]i. Acting as an intracellular messenger, Ca2+ has a key role in cell signaling pathways in various differentiation stages of stem cells. The aim of this chapter is to present a broad overview of various moments in which Ca2+-mediated signaling is essential for the maintenance of stem cells and for promoting their development and differentiation, also focusing on their therapeutic potential.

Keywords

Calcium transients Embryonic stem cells GPCR and RTK receptors Calcium signaling Stem cells differentiation