Stem Cells and Calcium Signaling

  • Fernanda M. P. Tonelli
  • Anderson K. Santos
  • Dawidson A. Gomes
  • Saulo L. da Silva
  • Katia N. Gomes
  • Luiz O. Ladeira
  • Rodrigo R. ResendeEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 740)


The increasing interest in stem cell research is linked to the promise of developing treatments for many lifethreatening, debilitating diseases, and for cell replacement therapies. However, performing these therapeutic innovations with safety will only be possible when an accurate knowledge about the molecular signals that promote the desired cell fate is reached. Among these signals are transient changes in intracellular Ca2+ concentration [Ca2+]i. Acting as an intracellular messenger, Ca2+ has a key role in cell signaling pathways in various differentiation stages of stem cells. The aim of this chapter is to present a broad overview of various moments in which Ca2+-mediated signaling is essential for the maintenance of stem cells and for promoting their development and differentiation, also focusing on their therapeutic potential.


Calcium transients Embryonic stem cells GPCR and RTK receptors Calcium signaling Stem cells differentiation 



7-transmembrane segment receptor


Protein kinase B


Amplitude modulation


Brain-derived neurotrophic factor


Bone morphogenetic protein


Bone morphogenetic protein 4


Calcium/calmodulin dependent kinase protein


Calcium sensing receptor


Cyclic adenosine monophosphate


Cyclic guanosine monophosphate


Binding element responsive to cAMP




Dickkopf 1


Embryonic carcimona cells


Extracellular matrix


Eph-related tyrosine kinase


Endoplasmatic reticulum


Extracellular-signal-regulated kinase


Embryonic stem cells


Extraembryonic endoderm


Fibroblast growth factor


Fibroblast growth factor 1


Fibroblast growth factor 2




Frequency modulation




Green fluorescent protein


G protein-coupled receptor


Human embryonic stem cell


Human hematopoietic stem cell


Human mesenchymal stem cell


Hematopoietic stem cell


Inner cell mass


Mitotically inactivated embryonic fibroblast


Inositol 1,4,5-triphosphate


Inositol 1,4,5-triphosphate receptors


Induced pluripotent stem cell


in vitro fertilized


Janus kinase


Gut-enriched Krüppel-like factor


Leukemia inhibitory factor


Lysophosphatidic acid


Mitogen-activated Protein Kinase Kinase 3


Microtubule-associated protein


Protein association with the microtubule 1B


Protein associated with type 2 microtubule


Pathways of mitogen-activated protein kinases


MAP kinase kinase


Mouse embryonic stem cell


Nicotinic Acid Adenine Dinucleotide


Nanog homeobox


Nuclear factors of activated T-cells


Nuclear factor κBl


Neural stem cell


Oct/octamer-associated protein


Octamer-binding transcription factor 4


Phosphoinositide Kinase-3


Phosphatidylinositol 4,5-biphosphate


Protein kinase A


Protein kinase C


Phospholipase C


Pluripotent stem cell


Rat sarcoma similar to G protein GTPase




Ryanodine receptors


Receptor-operated channels


Receptors tyrosine kinase


Serine/threonine kinase 40


Sex determining region Y box 2


Sarcoplasmatic reticulum


Store-operated channels


Somatic stem cell


Signal transducer and activator of transcription 3


Serine/threonine kinase 40


T-box transcription factor




Transforming growth factor-β


Tumor stem cell


Voltage-operated calcium channels



This work was supported by Instituto Nacional de Ciência e Tecnologia de Nanomateriais de Carbono, CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), Brazil. R.R.R, L.O.L., K.N.G., and D.A.G. are grateful for grants from CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), FAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais), and CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior).


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Fernanda M. P. Tonelli
    • 3
  • Anderson K. Santos
    • 3
  • Dawidson A. Gomes
    • 2
  • Saulo L. da Silva
    • 3
  • Katia N. Gomes
    • 1
  • Luiz O. Ladeira
    • 3
  • Rodrigo R. Resende
    • 3
    • 1
    Email author
  1. 1.Nanomaterials Laboratory, Department of Physics, Institute of Exact SciencesFederal University of Minas GeraisBelo HorizonteBrazil
  2. 2.Department of Biochemistry and Immunology, Institute of Biological SciencesFederal University of Minas GeraisBelo HorizonteBrazil
  3. 3.Universidade Federal de São João Del Rei Campus Alto ParaopebaBelo HorizonteBrazil

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