Calcium Signaling pp 235-254

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 740) | Cite as

Phospholipase C

Chapter

Abstract

Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen different family members have been cloned. These family members have unique structures that mediate diverse functions. Although PLC family members all appear to signal through the bi-products of cleaving phospholipids, it is clear that each family member, and at times each isoform, contributes to unique cellular functions. This chapter provides a review of the current literature. In addition, references have been provided for more in depth information regarding areas that are discussed. Ultimately, understanding the roles of the individual PLC enzymes, and their distinct cellular functions, will lead to a better understanding of the development of diseases and the maintenance of homeostasis.

Keywords

Calcium Diacyl glycerol Heterotrimeric G protein Inositol triphosphate Isoforms Isozymes Phosphatidyl inositol Phospholipase C Signal transduction Structure 

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Department of Microbiology, Molecular Genetics and ImmunologyUniversity of Kansas Medical CenterKansas CityUSA

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